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Polymerase: Human Pol eta

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Polymerase Reference Property Result Context
Human Pol eta Low fidelity DNA synthesis by human DNA polymerase-eta. 3-5' Exonuclease (proofreading) No
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 1.7n/a Reaction: Nucleotide incorporation; Substrate: dATP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 55n/a Reaction: Nucleotide incorporation; Substrate: dCTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 3.2n/a Reaction: Nucleotide incorporation; Substrate: dGTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 38n/a Reaction: Nucleotide incorporation; Substrate: dTTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 4 /minute Reaction: Nucleotide incorporation; Substrate: dATP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 2.2 /minute Reaction: Nucleotide incorporation; Substrate: dCTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 3.6 /minute Reaction: Nucleotide incorporation; Substrate: dGTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 2.1 /minute Reaction: Nucleotide incorporation; Substrate: dTTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Processivity 0.84bp
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Vmax 1.3 /second Reaction: Nucleotide incorporation; Substrate: dNTPs
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Kd 2.4nM Reaction: Nucleotide incorporation; Substrate: dATP
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Kd 13uM Reaction: Misincorporation; Substrate: dCTP
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Kd 11nM Reaction: Polymerase-DNA interaction; Substrate: DNA template
Human Pol eta Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. kcat 0.01 /second Reaction: Nucleotide incorporation; Substrate: dNTPs
Human Pol eta Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. 3-5' Exonuclease (proofreading) Yes
Human Pol eta Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. 3-5' Exonuclease (proofreading) Yes
Human Pol eta Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. 5-3' Exonuclease Unspecified
Human Pol eta Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. 5-3' Exonuclease Unspecified
Human Pol eta Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. Nucleotide Substitution Rate 0.035 errors/bp
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. 3-5' Exonuclease (proofreading) No
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Cloned or native Insect cells
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Tagged Yes
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Tag Name C-terminal His
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Nucleotide Substitution Rate 0.032 errors/bp Technique: M13mp2 forward mutation assay
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Full length or truncated Full length
Human Pol eta Error rate and specificity of human and murine DNA polymerase eta. Gap Filling Yes
Human Pol eta Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. 3-5' Exonuclease (proofreading) No
Human Pol eta Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Template lesions Bypasses Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Nucleotide Substitution Rate 0.0357 errors/bp Technique: Forward mutational
Human Pol eta Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Full length or truncated Full length
Human Pol eta The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Frameshift Error Rate 0.0024 errors/bp Technique: M13mp2 forward mutation assay
Human Pol eta The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Nucleotide Substitution Rate 0.035 errors/bp Technique: M13mp2 forward mutation assay
Human Pol eta Emerging links between hypermutation of antibody genes and DNA polymerases. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: 8-hydroxyguanine
Human Pol eta Emerging links between hypermutation of antibody genes and DNA polymerases. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: UV-induced Pyrimidine Dimer
Human Pol eta Emerging links between hypermutation of antibody genes and DNA polymerases. Overall Error Rate 0.03 errors/bp Technique: Sequencing
Human Pol eta Emerging links between hypermutation of antibody genes and DNA polymerases. Associated condition hypermutation and/or XERODERMA PIGMENTOSUM
Human Pol eta Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA

Version:20241218

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.