Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

DNA repair (2003), Volume 2, Page 135

Abstract:

Human DNA polymerases eta, kappa and iota are template-dependent, Y-family DNA polymerases that have been implicated in translesion DNA synthesis (TLS) in human cells. Here, we briefly review evidence that these exonuclease-deficient polymerases copy undamaged DNA with very low fidelity and unusual error specificity. Based on the base substitution specificity and other biochemical properties of DNA polymerases eta and iota, we consider the possibility that they participate in specialized DNA transactions that repair damaged DNA and/or generate mutations in the variable regions of immunoglobulin genes.

Polymerases:

Topics:

Exonuclease Activity, Nucleotide Analogs / Template Lesions, Fidelity, Source / Purification, Nucleotide Incorporation

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol eta Kunkel TA2003 3-5' Exonuclease (proofreading) No
Human Pol eta Kunkel TA2003 Template lesions Bypasses Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Kunkel TA2003 Nucleotide Substitution Rate 0.0357 errors/bp Technique: Forward mutational
Human Pol eta Kunkel TA2003 Full length or truncated Full length
Human Pol kappa Kunkel TA2003 3-5' Exonuclease (proofreading) No
Human Pol kappa Kunkel TA2003 Nucleotide Substitution Rate 0.0066 errors/bp
Human Pol kappa Kunkel TA2003 Full length or truncated Full length
Human Pol iota Kunkel TA2003 3-5' Exonuclease (proofreading) No
Human Pol iota Kunkel TA2003 Overall Error Rate 0.0002 errors/bp
Human Pol iota Kunkel TA2003 Full length or truncated Full length
Human Pol iota Kunkel TA2003 Gap Filling Yes

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