Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine.

Abstract:

The oxidative stress products malondialdehyde and base propenal react ...

Polymerases:

Topics:

Nucleotide Analogs / Template Lesions, Exonuclease Activity

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol beta Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: OPdA
Human Pol kappa Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol eta Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
Human Pol iota Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Idles Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
SsoDpo1 Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA
T7 Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Idles Reaction: Nucleotide incorporation; Substrate: dTTP; DNA lesion: OPdA

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