Sce Pol alpha
Welcome to the Polymerase Page
This page presents all the information in Polbase for Sce Pol alpha.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Selected Properties for Sce Pol alpha: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| no consensus | no consensus | no data | 3.4e-03 errors/bp (1) | no data |
- References (20)
- Structures (2)
- Sequences (1)
- Mutants (1)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Erik Johansson, Stuart A Macneill | The eukaryotic replicative DNA polyme... | |
| 2009 | Sebastian Klinge, Rafael Núñez-Ramírez, Oscar Llorca, Luca Pellegrini | 3D architecture of DNA Pol alpha reve... | |
| 2008 | Anne M Casper, Piotr A Mieczkowski, Malgorzata Gawel, Thomas D Petes | Low levels of DNA polymerase alpha in... | |
| 2004 | Atsuko Niimi, Siripan Limsirichaikul, Shonen Yoshida, Shigenori Iwai, Chikahide Masutani, Fumio Hanaoka, Eric T Kool, Yoshitaka Nishiyama, Motoshi Suzuki | Palm mutants in DNA polymerases alpha... | |
| 2004 | Robin M Ricke, Anja-Katrin Bielinsky | Mcm10 regulates the stability and chr... | |
| 2003 | Siripan Limsirichaikul, Masanori Ogawa, Atsuko Niimi, Shigenori Iwai, Takashi Murate, Shonen Yoshida, Motoshi Suzuki | The Gly-952 residue of Saccharomyces ... | |
| 2003 | Subhasis B Biswas, Sujata M Khopde, Fan xiu Zhu Fx, Esther E Biswas | Subunit interactions in the assembly ... | |
| 2003 | Masanori Ogawa, Siripan Limsirichaikul, Atsuko Niimi, Shigenori Iwai, Shonen Yoshida, Motoshi Suzuki | Distinct function of conserved amino ... | Cloned or native,Tagged,Full length or truncated,Specific Activity,Processivity,Nucleotide Substitution Rate,All properties |
| 1997 | F X Zhu, Esther E Biswas, Subhasis B Biswas | Purification and characterization of ... | 5-3' exo,RNase H,All properties |
| 1997 | J Wittmeyer, T Formosa | The Saccharomyces cerevisiae DNA poly... | |
| 1994 | S H Leem, P A Ropp, Akio Sugino | The yeast Saccharomyces cerevisiae DN... | |
| 1993 | Zhengqiang Wang, Xiaoming Wu, Errol C Friedberg | DNA repair synthesis during base exci... | |
| 1991 | Thomas A Kunkel, J D Roberts, Akio Sugino | The fidelity of DNA synthesis by the ... | |
| 1991 | R G Brooke, R Singhal, David C Hinkle, L B Dumas | Purification and characterization of ... | Cloned or native,Full length or truncated,Processivity,3-5' exo,KM,Molecular Weight,All properties |
| 1990 | Robert K Hamatake, H Hasegawa, Alan B Clark, Katarzyna Bebenek, Thomas A Kunkel, Akio Sugino | Purification and characterization of ... | Specific Activity,Processivity,3-5' exo,5-3' exo,KM,Molecular Weight,All properties |
| 1977 | L M Chang | DNA polymerases from bakers' yeast. | |
| 1974 | U Wintersberger | Absence of a low-molecular-weight DNA... | |
| 1970 | U Wintersberger, E Wintersberger | Studies on deoxyribonucleic acid poly... | |
| 1967 | H Eckstein, V Paduch, H Hilz | Synchronized yeast cells. 3. DNA synt... |
Predicted Structure Model
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Sce Pol alpha Y951P | 3.4e-03 errors/bp (1) |
Protein information: Uniprot P13382 search for Sce Pol alpha at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-P13382-F1