HIV RT Y181C

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This page presents all the information in Polbase for HIV RT Y181C.

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Mutant of: HIV RT (Y181C)

HIV RT Y181C is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:926|codon:TAT>TGT|drugs:MSK-076|class:noncompetitive RT inhibitor|notes:HIV-1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:477|codon:TAT>TGT|drugs:1737 From the Los Alamos National Labs HIV Mutant database (now offline):|id:478|codon:TAT>TGT|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:>28-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:479|codon:TAT>TGT|drugs:alpha-APA "From the Los Alamos National Labs HIV Mutant database (now offline):|id:480|codon:TAT>TGT|drugs:BHAP U-87201E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:481|codon:TAT>TGT|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:482|codon:TAT>TGT|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:483|codon:TAT>TGT|drugs:BM+51.0836 |class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:484|codon:TAT>TGT|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:485|codon:TAT>TGT|drugs:E-BPTU From the Los Alamos National Labs HIV Mutant database (now offline):|id:486|codon:TAT>TGT|drugs:E-EBU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:160-fold resistant From the Los Alamos National Labs HIV Mutant database (now offline):|id:487|codon:TAT>TGT|drugs:E-EPSeU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C confers greater resistance (>250-fold) than Y181C (>50-fold) From the Los Alamos National Labs HIV Mutant database (now offline):|id:488|codon:TAT>TGT|drugs:E-EPU |class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C (>250-fold)confers greater resistance than Y181C (>95-fold) "From the Los Alamos National Labs HIV Mutant database (now offline):|id:489|codon:TAT>TGT|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:490|codon:TAT>TGT|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:491|codon:TAT>TGT|drugs:LY-300046 HCl From the Los Alamos National Labs HIV Mutant database (now offline):|id:493|codon:TAT>TGT|drugs:O-(2-Phenoxy ethyl)benzoyl (phenyl) thiocarbamate 17c|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Low potency also against K103N/Y181C "From the Los Alamos National Labs HIV Mutant database (now offline):|id:494|codon:TAT>TGT|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103N/Y181C: > 1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:495|codon:TAT>TGT|drugs:UC-10 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:496|codon:TAT>TGT|drugs:UC-32 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:497|codon:TAT>TGT|drugs:UC-38 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:498|codon:TAT>TGT|drugs:UC-57 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:499|codon:TAT>TGT|drugs:UC-581 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:500|codon:TAT>TGT|drugs:UC-68 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:501|codon:TAT>TGT|drugs:UC-69 From the Los Alamos National Labs HIV Mutant database (now offline):|id:502|codon:TAT>TGT|drugs:UC-781|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:By passage 5: 50-fold-R "From the Los Alamos National Labs HIV Mutant database (now offline):|id:503|codon:TAT>TGT|drugs:UC-80 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:504|codon:TAT>TGT|drugs:UC-81 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:505|codon:TAT>TGT|drugs:UC-84

Selected Properties for HIV RT Y181C:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2008 Kalyan Das, Joseph David Bauman, Arthur D Clark, Yulia Volovik Frenkel, Paul J Lewi, Aaron J Shatkin, Stephen H Hughes, Edward Arnold High-resolution structures of HIV-1 r... RT,All properties
2005 Johan Vingerhoets, Hilde Azijn, Els Fransen, Inky De Baere, Liesbet Smeulders, Dirk Jochmans, Koen Andries, Rudi Pauwels, Marie-Pierre P De Béthune TMC125 displays a high genetic barrie...
2004 Joeri Auwerx, Miguel Stevens, An R Van Rompay, Louise E Bird, Jingshan Ren, Erik De Clercq, Bo Oberg, David K Stammers, Anna Karlsson, Jan Balzarini The phenylmethylthiazolylthiourea non...
2003 Angelo Ranise, Andrea Spallarossa, Silvia Schenone, Olga Bruno, Francesco Bondavalli, Laura Vargiu, Tiziana Marceddu, Massimo Mura, Paolo La Colla, Alessandra Pani Design, synthesis, SAR, and molecular...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1998 L M Demeter, P M Meehan, G Morse, M A Fischl, M Para, W Powderly, J Leedom, J Holden-Wiltse, C Greisberger, K Wood, J Timpone, L K Wathen, T Nevin, L Resnick, D H Batts, R C Reichman Phase I study of atevirdine mesylate ...
1997 H Hara, T Fujihashi, T Sakata, A Kaji, H Kaji Tetrahydronaphthalene lignan compound...
1997 Robert W Buckheit, M J Snow, V Fliakas-Boltz, T L Kinjerski, J D Russell, L A Pallansch, W G Brouwer, S S Yang Highly potent oxathiin carboxanilide ...
1996 Kalyan Das, Jianping Ding, Y Hsiou, Arthur D Clark, H Moereels, Luc Koymans, Koen Andries, Rudi Pauwels, Paul A J Janssen, Paul L Boyer, Patrick K Clark, Richard H Smith, Marilyn B Kroeger Smith, Christopher J Michejda, Stephen H Hughes, Edward Arnold Crystal structures of 8-Cl and 9-Cl T...
1996 Schlomo Staszewski, V Miller, A Kober, R Colebunders, B Vandercam, J Delescluse, N Clumeck, F Van Wanzeele, M De Brabander, J De Creé, M Moeremans, Koen Andries, C Boucher, Paul Stoffels, Paul A J Janssen Evaluation of the efficacy and tolera...
1996 D L Winslow, S Garber, C Reid, H Scarnati, D Baker, M M Rayner, E D Anton Selection conditions affect the evolu...
1995 Robert W Buckheit, V Fliakas-Boltz, S Yeagy-Bargo, O Weislow, D L Mayers, Paul L Boyer, Stephen H Hughes, B C Pan, S H Chu, J P Bader Resistance to 1-[(2-hydroxyethoxy)met...
1995 Haijiang Zhang, L Vrang, K Bäckbro, P Lind, Christer Sahlberg, Torsten Unge, Bo Oberg Inhibition of human immunodeficiency ...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Resistance of human immunodeficiency ...
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Nevirapine resistance mutations of hu...
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Resistance of human immunodeficiency ...
1993 M S Saag, E A Emini, O L Laskin, J Douglas, W I Lapidus, W A Schleif, R J Whitley, C Hildebrand, V W Byrnes, John C Kappes A short-term clinical evaluation of L...
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Comprehensive mutant enzyme and viral...
1993 G Maass, U Immendoerfer, B Koenig, U Leser, B Mueller, R Goody, E Pfaff Viral resistance to the thiazolo-iso-...
1993 Jan Balzarini, Anna Karlsson, Erik De Clercq Human immunodeficiency virus type 1 d...
1992 John W Mellors, Ginger E Dutschman, G J Im, Enzo Tramontano, S R Winkler, Yung-Chi Cheng In vitro selection and molecular char...
1992 M B Vasudevachari, C Battista, H C Lane, M C Psallidopoulos, B Zhao, J Cook, J R Palmer, D L Romero, W G Tarpley, N P Salzman Prevention of the spread of HIV-1 inf...
1991 J H Nunberg, W A Schleif, E J Boots, J A O'Brien, J C Quintero, J M Hoffman, E A Emini, M E Goldman Viral resistance to human immunodefic...
1991 D Richman, C K Shih, I Lowy, J Rose, P Prodanovich, S Goff, J Griffin Human immunodeficiency virus type 1 m...

Version:20241007

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