HIV RT Y181C

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This page presents all the information in Polbase for HIV RT Y181C.

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Mutant of: HIV RT (Y181C)

HIV RT Y181C is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:926|codon:TAT>TGT|drugs:MSK-076|class:noncompetitive RT inhibitor|notes:HIV-1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:477|codon:TAT>TGT|drugs:1737 From the Los Alamos National Labs HIV Mutant database (now offline):|id:478|codon:TAT>TGT|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:>28-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:479|codon:TAT>TGT|drugs:alpha-APA "From the Los Alamos National Labs HIV Mutant database (now offline):|id:480|codon:TAT>TGT|drugs:BHAP U-87201E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:481|codon:TAT>TGT|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:482|codon:TAT>TGT|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:483|codon:TAT>TGT|drugs:BM+51.0836 |class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:484|codon:TAT>TGT|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:485|codon:TAT>TGT|drugs:E-BPTU From the Los Alamos National Labs HIV Mutant database (now offline):|id:486|codon:TAT>TGT|drugs:E-EBU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:160-fold resistant From the Los Alamos National Labs HIV Mutant database (now offline):|id:487|codon:TAT>TGT|drugs:E-EPSeU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C confers greater resistance (>250-fold) than Y181C (>50-fold) From the Los Alamos National Labs HIV Mutant database (now offline):|id:488|codon:TAT>TGT|drugs:E-EPU |class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C (>250-fold)confers greater resistance than Y181C (>95-fold) "From the Los Alamos National Labs HIV Mutant database (now offline):|id:489|codon:TAT>TGT|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:490|codon:TAT>TGT|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:491|codon:TAT>TGT|drugs:LY-300046 HCl From the Los Alamos National Labs HIV Mutant database (now offline):|id:493|codon:TAT>TGT|drugs:O-(2-Phenoxy ethyl)benzoyl (phenyl) thiocarbamate 17c|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Low potency also against K103N/Y181C "From the Los Alamos National Labs HIV Mutant database (now offline):|id:494|codon:TAT>TGT|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:K103N/Y181C: > 1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:495|codon:TAT>TGT|drugs:UC-10 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:496|codon:TAT>TGT|drugs:UC-32 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:497|codon:TAT>TGT|drugs:UC-38 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:498|codon:TAT>TGT|drugs:UC-57 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:499|codon:TAT>TGT|drugs:UC-581 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:500|codon:TAT>TGT|drugs:UC-68 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:501|codon:TAT>TGT|drugs:UC-69 From the Los Alamos National Labs HIV Mutant database (now offline):|id:502|codon:TAT>TGT|drugs:UC-781|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:By passage 5: 50-fold-R "From the Los Alamos National Labs HIV Mutant database (now offline):|id:503|codon:TAT>TGT|drugs:UC-80 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:504|codon:TAT>TGT|drugs:UC-81 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:505|codon:TAT>TGT|drugs:UC-84

Selected Properties for HIV RT Y181C:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
Unknown
2008 Kalyan Das, Joseph David Bauman, Arthur D Clark, Yulia Volovik Frenkel, Paul J Lewi, Aaron J Shatkin, Stephen H Hughes, Edward Arnold Das K2008 RT,All properties
2005 Johan Vingerhoets, Hilde Azijn, Els Fransen, Inky De Baere, Liesbet Smeulders, Dirk Jochmans, Koen Andries, Rudi Pauwels, Marie-Pierre P De Béthune Vingerhoets J2005
2004 Joeri Auwerx, Miguel Stevens, An R Van Rompay, Louise E Bird, Jingshan Ren, Erik De Clercq, Bo Oberg, David K Stammers, Anna Karlsson, Jan Balzarini Auwerx J2004
2003 Angelo Ranise, Andrea Spallarossa, Silvia Schenone, Olga Bruno, Francesco Bondavalli, Laura Vargiu, Tiziana Marceddu, Massimo Mura, Paolo La Colla, Alessandra Pani Ranise A2003
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit Cushman M1998
1998 L M Demeter, P M Meehan, G Morse, M A Fischl, M Para, W Powderly, J Leedom, J Holden-Wiltse, C Greisberger, K Wood, J Timpone, L K Wathen, T Nevin, L Resnick, D H Batts, R C Reichman Demeter LM1998
1997 H Hara, T Fujihashi, T Sakata, A Kaji, H Kaji Hara H1997
1997 Robert W Buckheit, M J Snow, V Fliakas-Boltz, T L Kinjerski, J D Russell, L A Pallansch, W G Brouwer, S S Yang Buckheit RW1997
1996 Kalyan Das, Jianping Ding, Y Hsiou, Arthur D Clark, H Moereels, Luc Koymans, Koen Andries, Rudi Pauwels, Paul A J Janssen, Paul L Boyer, Patrick K Clark, Richard H Smith, Marilyn B Kroeger Smith, Christopher J Michejda, Stephen H Hughes, Edward Arnold Das K1996
1996 Schlomo Staszewski, V Miller, A Kober, R Colebunders, B Vandercam, J Delescluse, N Clumeck, F Van Wanzeele, M De Brabander, J De Creé, M Moeremans, Koen Andries, C Boucher, Paul Stoffels, Paul A J Janssen Staszewski S1996
1996 D L Winslow, S Garber, C Reid, H Scarnati, D Baker, M M Rayner, E D Anton Winslow DL1996
1995 Robert W Buckheit, V Fliakas-Boltz, S Yeagy-Bargo, O Weislow, D L Mayers, Paul L Boyer, Stephen H Hughes, B C Pan, S H Chu, J P Bader Buckheit RW1995
1995 Haijiang Zhang, L Vrang, K Bäckbro, P Lind, Christer Sahlberg, Torsten Unge, Bo Oberg Zhang H1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Balzarini J1995
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Nguyen MH1994
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Richman DD1994
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Nguyen MH1994
1993 M S Saag, E A Emini, O L Laskin, J Douglas, W I Lapidus, W A Schleif, R J Whitley, C Hildebrand, V W Byrnes, John C Kappes Saag MS1993
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Byrnes VW1993
1993 G Maass, U Immendoerfer, B Koenig, U Leser, B Mueller, R Goody, E Pfaff Maass G1993
1993 Jan Balzarini, Anna Karlsson, Erik De Clercq Balzarini J1993
1992 John W Mellors, Ginger E Dutschman, G J Im, Enzo Tramontano, S R Winkler, Yung-Chi Cheng Mellors JW1992
1992 M B Vasudevachari, C Battista, H C Lane, M C Psallidopoulos, B Zhao, J Cook, J R Palmer, D L Romero, W G Tarpley, N P Salzman Vasudevachari MB1992
1991 J H Nunberg, W A Schleif, E J Boots, J A O'Brien, J C Quintero, J M Hoffman, E A Emini, M E Goldman Nunberg JH1991
1991 D Richman, C K Shih, I Lowy, J Rose, P Prodanovich, S Goff, J Griffin Richman D1991
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