HIV RT K103N

From HIV
show help

Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT K103N.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Mutant of: HIV RT (K103N)

HIV RT K103N is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:401|codon:AAA>AAC|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:>28-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:402|codon:AAA>AAC|drugs:BHAP U-87201E "From the Los Alamos National Labs HIV Mutant database (now offline):|id:403|codon:AAA>AAC|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:404|codon:AAA>AAC|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:405|codon:AAA>AAC|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:406|codon:AAA>AAC|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:408|codon:AAA>AAC|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:>100-fold alone. K103N/Y181C: > 1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:409|codon:AAA>AAC|drugs:UC-10 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:410|codon:AAA>AAC|drugs:UC-81

Selected Properties for HIV RT K103N:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2010 Michael L Mitchell, Jong Chan Son, Ill Young Lee, Chong-Kyo Lee, Hae Soo Kim, Hongyan Guo, Jianhong Wang, Jaclyn Hayes, Michael Wang, Amber Paul, Eric B Lansdon, James M Chen, Gene Eisenberg, Romas Geleziunas, Lianhong Xu, Choung U Kim N1-Heterocyclic pyrimidinediones as n... RT,All properties
2010 Eric B Lansdon, Katherine M Brendza, Magdeleine Hung, Ruth Wang, Susmith Mukund, Debi Jin, Gabriel Birkus, Nilima Kutty, Xiaohong Liu Crystal structures of HIV-1 reverse t... RT,All properties
2010 Romuald Corbau, Julie Mori, Chris Phillips, Lesley Fishburn, Alex Martin, Charles Mowbray, Wendy Panton, Caroline Smith-Burchnell, Adele Thornberry, Heather Ringrose, Thorsten Knöchel, Steve Irving, Mike Westby, Anthony Wood, Manos Perros Lersivirine: a Non-Nucleoside Reverse... RT,All properties
2010 Denis J Kertesz, Christine Brotherton-Pleiss, Minmin Yang, Zhengqiang Wang, Xianfeng Lin, Zongxing Qiu, Donald R Hirschfeld, Shelley K Gleason, Taraneh Mirzadegan, Pete W Dunten, Seth F Harris, Armando G Villaseñor, Julie Qi Hang, Gabrielle M Heilek, Klaus Klumpp Discovery of piperidin-4-yl-aminopyri...
2008 Kalyan Das, Joseph David Bauman, Arthur D Clark, Yulia Volovik Frenkel, Paul J Lewi, Aaron J Shatkin, Stephen H Hughes, Edward Arnold High-resolution structures of HIV-1 r... RT,All properties
2005 Johan Vingerhoets, Hilde Azijn, Els Fransen, Inky De Baere, Liesbet Smeulders, Dirk Jochmans, Koen Andries, Rudi Pauwels, Marie-Pierre P De Béthune TMC125 displays a high genetic barrie...
2004 Kalyan Das, Arthur D Clark, Paul J Lewi, Jan Heeres, Marc R De Jonge, Lucien M H Koymans, H Maarten Vinkers, Frederik Daeyaert, Donald W Ludovici, Michael J Kukla, Bart De Corte, Robert W Kavash, Chih Y Ho, Hong Ye, Mark A Lichtenstein, Koen Andries, Rudi Pauwels, Marie-Pierre P De Béthune, Paul L Boyer, Patrick K Clark, Stephen H Hughes, Paul A J Janssen, Edward Arnold Roles of conformational and positiona... RT,Associated condition,All properties
2002 Jimmy Lindberg, Snaevar Sigurdsson, Seved Löwgren, Hans O Andersson, Christer Sahlberg, Rolf Noréen, Kerstin Fridborg, Haijiang Zhang, Torsten Unge Structural basis for the inhibitory e...
2000 Jingshan Ren, John Milton, Kurt L Weaver, Steven A Short, David I Stuart, David K Stammers Structural basis for the resilience o...
2000 L T Bacheler, E D Anton, P Kudish, D Baker, J Bunville, K Krakowski, L Bolling, M Aujay, X V Wang, D Ellis, M F Becker, A L Lasut, H J George, D R Spalding, G Hollis, K Abremski Human immunodeficiency virus type 1 m...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1998 L M Demeter, P M Meehan, G Morse, M A Fischl, M Para, W Powderly, J Leedom, J Holden-Wiltse, C Greisberger, K Wood, J Timpone, L K Wathen, T Nevin, L Resnick, D H Batts, R C Reichman Phase I study of atevirdine mesylate ...
1995 S D Young, S F Britcher, L O Tran, L S Payne, W C Lumma, T A Lyle, J R Huff, P S Anderson, David B Olsen, Steven S Carroll L-743, 726 (DMP-266): a novel, highly...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Nevirapine resistance mutations of hu...
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Comprehensive mutant enzyme and viral...
1993 M S Saag, E A Emini, O L Laskin, J Douglas, W I Lapidus, W A Schleif, R J Whitley, C Hildebrand, V W Byrnes, John C Kappes A short-term clinical evaluation of L...
1993 Jan Balzarini, Anna Karlsson, María-Jesús Pérez-Pérez, María-José Camarasa, W G Tarpley, Erik De Clercq Treatment of human immunodeficiency v...
1991 J H Nunberg, W A Schleif, E J Boots, J A O'Brien, J C Quintero, J M Hoffman, E A Emini, M E Goldman Viral resistance to human immunodefic...

Version:20241218

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.