Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Kertesz DJ, Brotherton-Pleiss C, Yang M, Wang Z, Lin X, Qiu Z, Hirschfeld DR, Gleason SK, Mirzadegan T, Dunten PW, Harris SF, VillaseƱor AG, Hang JQ, Heilek GM, Klumpp K
Bioorganic & medicinal chemistry letters (2010), Volume 20, Page 4215
Abstract:
Polymerases:
Topics:
Mutational Analysis, Structure and Structure/Function, Reverse Transcriptase
Status:
new | topics/pols set | partial results | complete | validated |
Results:
Polymerase | Reference | Property | Result | Context |
---|---|---|---|---|
HIV RT | Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. | Reverse Transcriptase Activity | Yes |