Human Pol theta

From H. sapiens (aliases:Pol Q) (genes: POLQ)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol theta.


At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.


If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.


All references that refer to this Polymerase are listed with their topics and paper's title in the References table.


All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

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The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol theta is a family A enzyme from H. sapiens.

Selected Properties for Human Pol theta:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
No (2) no data no data 2.4e-03 errors/bp (1) 1.0e-03-1.0e-02 errors/bp (4)
Year Authors Title Results by property
2011 M Hogg, AE Sauer-Eriksson, Erik Johansson Promiscuous DNA synthesis by human DN...
2010 Mark D Sutton Coordinating DNA polymerase traffic d...
2009 Rajendra Prasad, Matthew J Longley, Farida S Sharief, Esther W Hou, William C Copeland, Samuel H Wilson Human DNA polymerase theta possesses ...
2009 Takuji Oyama, Hayato Oka, Kouta Mayanagi, Tsuyoshi Shirai, Kyoko Matoba, Ryosuke Fujikane, Yoshizumi Ishino, Kosuke Morikawa Atomic structures and functional impl...
2008 Mercedes E Arana, Masayuki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel Low-fidelity DNA synthesis by human D... Full length or truncated,3-5' exo,Nucleotide Substitution Rate,Molecular Weight,Overall Error Rate,All properties
2004 Masayuki Seki, Chikahide Masutani, Lee Wei Yang, Anthony Schuffert, Shigenori Iwai, Ivet Bahar, Richard D Wood High-efficiency bypass of DNA damage ...
2003 Masayuki Seki, Federica Marini, Richard D Wood POLQ (Pol theta), a DNA polymerase an...
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Eukaryotic DNA polymerases.
2000 Robert E Johnson, Satya Prakash, Louise Prakash The human DINB1 gene encodes the DNA ... Cloned or native,Tagged,Tag Name,3-5' exo,Template lesions,Overall Error Rate,All properties
1999 Farida S Sharief, P J Vojta, P A Ropp, William C Copeland Cloning and chromosomal mapping of th...
Protein sequence:

Using Polbase tables:


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