Low-fidelity DNA synthesis by human DNA polymerase theta.

Abstract:

Human DNA polymerase theta (pol or POLQ) is a proofreading-deficient ...

Polymerases:

Topics:

Historical Protein Properties (MW, pI, ...), Fidelity, Exonuclease Activity, Source / Purification

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. Molecular Weight 290kD
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. 3-5' Exonuclease (proofreading) No
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. Overall Error Rate 0.0014 errors/bp Technique: M13mp2 forward mutation assay (Single base deletions)
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. Overall Error Rate 0.0033 errors/bp Technique: M13mp2 forward mutation assay (Single base additions)
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleotide Substitution Rate 0.0024 errors/bp Technique: M13mp2 forward mutation assay
Human Pol theta Low-fidelity DNA synthesis by human DNA polymerase theta. Full length or truncated Full length

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