Human Pol theta
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol theta.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Selected Properties for Human Pol theta: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (2) | no data | no data | 2.4e-03 errors/bp (1) | 1.0e-03-1.0e-02 errors/bp (4) |
- References (10)
- Structures (1)
- Sequences (1)
- Mutants (0)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2011 | M Hogg, AE Sauer-Eriksson, Erik Johansson | Promiscuous DNA synthesis by human DN... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2009 | Rajendra Prasad, Matthew J Longley, Farida S Sharief, Esther W Hou, William C Copeland, Samuel H Wilson | Human DNA polymerase theta possesses ... | |
| 2009 | Takuji Oyama, Hayato Oka, Kouta Mayanagi, Tsuyoshi Shirai, Kyoko Matoba, Ryosuke Fujikane, Yoshizumi Ishino, Kosuke Morikawa | Atomic structures and functional impl... | |
| 2008 | Mercedes E Arana, Masayuki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel | Low-fidelity DNA synthesis by human D... | Full length or truncated,3-5' exo,Nucleotide Substitution Rate,Molecular Weight,Overall Error Rate,All properties |
| 2004 | Masayuki Seki, Chikahide Masutani, Lee Wei Yang, Anthony Schuffert, Shigenori Iwai, Ivet Bahar, Richard D Wood | High-efficiency bypass of DNA damage ... | |
| 2003 | Masayuki Seki, Federica Marini, Richard D Wood | POLQ (Pol theta), a DNA polymerase an... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2000 | Robert E Johnson, Satya Prakash, Louise Prakash | The human DINB1 gene encodes the DNA ... | Cloned or native,Tagged,Tag Name,3-5' exo,Template lesions,Overall Error Rate,All properties |
| 1999 | Farida S Sharief, P J Vojta, P A Ropp, William C Copeland | Cloning and chromosomal mapping of th... |
Predicted Structure Model
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
Protein information: Uniprot O75417 search for Human Pol theta at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-O75417-F1