Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis.

Abstract:

Mutagenic DNA adducts have been analyzed with respect to the rate of ...

Polymerases:

Topics:

Nucleotide Analogs / Template Lesions, Exonuclease Activity

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Klenow fragment Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. Template lesions Bypasses Reaction: Nucleotide incorporation; DNA lesion: 8-oxo-dG
Klenow (exo-) Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. 3-5' Exonuclease (proofreading) No
Klenow (exo-) Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. 5-3' Exonuclease Unspecified

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