Klenow fragment

From E. coli (aliases:Klenow fragment, KF, Klenow fragment of E. coli DNA polymerase I, Klenow fragment of Pol I, Klenow, Pol Ik, Pol I(KF))
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Klenow fragment is a family A enzyme from E. coli.

Original enzyme used in PCR (since replaced by thermostable enzymes like Taq)

Original enzyme used in chain-terminator sequencing (Sanger)

First DNA polymerase crystal structure

Originally produced by protease digestion of DNA Pol I; subsequently made from a cloned construct.

Many of the papers in the collection describe studies using exo-minus Klenow fragment.  No attempt has been made to separate these out.

Selected Properties for Klenow fragment:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (16) No (8) 6.0e-07-1.0e-02 errors/bp (3) 5.8e-06-2.8e-03 errors/bp (6) 4.0e-05-5.2e-03 errors/bp (6)
Year Authors Title Results by property
2013 Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett Replication, Repair and Translesion P...
2013 Junpei Yamamoto, Tomoko Oyama, Tomohiro Kunishi, Chikahide Masutani, Fumio Hanaoka, Shigenori Iwai A cyclobutane thymine-N4-methylcytosi...
2013 Hongyun Wang, Nicholas Hurt, William B Dunbar Measuring and modeling the kinetics o...
2013 Ping Xie Dynamics of DNA polymerase I (Klenow ...
2012 Prakasha Gowda A S, Gowdahalli Krishnegowda, Zucai Suo, Shantu G Amin, Thomas E Spratt Low fidelity bypass of O2-...
2012 Sarah E Graham, FatimaSultana Syeda, G Andrés Cisneros Computational prediction of residues ...
2011 Oya Bermek, Nigel D F Grindley, Catherine M Joyce Distinct roles of the active-site Mg2...
2011 Daniel R Garalde, Christopher A Simon, Joseph M Dahl, Hongyun Wang, Mark Akeson, Kate R Lieberman Distinct complexes of DNA polymerase ...
2011 M Hogg, AE Sauer-Eriksson, Erik Johansson Promiscuous DNA synthesis by human DN...
2011 Chen Song, Chen Zhang, Meiping Zhao Rapid and sensitive detection of DNA ...
2010 Linda J Reha-Krantz DNA polymerase proofreading: Multiple...
2010 Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa Consecutive incorporation of fluoroph...
2010 Guojie Zhao, Yifu Guan Polymerization behavior of Klenow fra...
2009 Md Monsur Ali, Shuhei Imoto, Yingqian Li, Shigeki Sasaki, Fumi Nagatsugi Incorporation of an inducible nucleot...
2009 Gudrun Stengel, Byron W Purse, L Marcus Wilhelmsson, Milan Urban, Robert D Kuchta Ambivalent incorporation of the fluor...
2009 Noriaki Minakawa, Shintaro Ogata, Mayumi Takahashi, Akira Matsuda Selective recognition of unnatural im...
2009 Brett Gyarfas, Felix Olasagasti, Seico Benner, Daniel R Garalde, Kate R Lieberman, Mark Akeson Mapping the position of DNA polymeras...
2009 Peter Sandin, Gudrun Stengel, Thomas Ljungdahl, Karl Börjesson, Bertil Macao, L Marcus Wilhelmsson Highly efficient incorporation of the... Vmax,Methods Featured,Incorporation of non-standard nucleotides,All properties
2009 Younguk Sun, Kalvin J Gregory, Val Golovlev Efficiency and specificity of microRN...
2008 Asim Sheriff, Edward Motea, Irene Lee, Anthony J Berdis Mechanism and dynamics of translesion...
2008 Pinky Kukreti, Kamalendra Singh, Amit Ketkar, Mukund J Modak Identification of a new motif require... 3-5' exo,5-3' exo,All properties
2008 Linda J Reha-Krantz Recent patents of gene sequences rela...
2008 Ravindra Venkatramani, Ravi Radhakrishnan Effect of oxidatively damaged DNA on ...
2008 Catherine M Joyce, Olga Potapova, Angela M DeLucia, Xuanwei Huang, Vandana Purohit Basu, Nigel D F Grindley Fingers-closing and other rapid confo... Cloned or native,Tagged,Tag Name,Full length or truncated,kcat,Methods Featured,All properties
2008 Janina Cramer, Gopinath Rangam, Andreas Marx, Tobias Restle Varied active-site constraints in the...
2007 Michael F Bailey, Edwin J C Van der Schans, David P Millar Dimerization of the Klenow fragment o...
2007 Yasushi Shigemori, Michio Oishi Specific terminal labeling of DNA mol...
2007 Flavia Barone, Scott D McCulloch, Peter Macpherson, Giovanni Maga, Masami Yamada, Takehiko Nohmi, Anna Minoprio, Filomena Mazzei, Thomas A Kunkel, Peter Karran, Margherita Bignami Replication of 2-hydroxyadenine-conta...
2007 Adam P Silverman, Qingfei Jiang, Myron F Goodman, Eric T Kool Steric and electrostatic effects in D...
2007 Gudrun Stengel, JP Gill, Peter Sandin, L Marcus Wilhelmsson, Bo Albinsson, Bengt Nordén, David P Millar Conformational dynamics of DNA polyme...
2006 Irene Lee, Anthony J Berdis Fluorescent analysis of translesion D...
2006 Shin Mizukami, Tae Woo Kim, Sandra A Helquist, Eric T Kool Varying DNA base-pair size in subangs...
2006 Ichiro Hirao, Michiko Kimoto, Tsuneo Mitsui, Tsuyoshi Fujiwara, Rie Kawai, Akira Sato, Yoko Harada, Shigeyuki Yokoyama An unnatural hydrophobic base pair sy...
2006 Changbei Ma, Zhiwen Tang, Kemin Wang, Weihong Tan, Jun Li, Wei Li, Zhongjie Li, Xiaohai Yang, Huimin Li, Lingfeng Liu Real-time monitoring of DNA polymeras...
2005 Alexander B Kotlyar, Natalia Borovok, Tatiana Molotsky, Dmitry Klinov, Benjamin Dwir, Eli Kapon Synthesis of novel poly(dG)-poly(dG)-... 3-5' exo,5-3' exo,All properties
2005 Kamalendra Singh, Mukund J Modak Contribution of polar residues of the... 3-5' exo,5-3' exo,All properties
2005 XinJing Tang, Julia L Richards, Adam E Peritz, Ivan J Dmochowski Photoregulation of DNA polymerase I (...
2005 Alexander B Kotlyar, Natalia Borovok, Tatiana Molotsky, Ludmila Fadeev, Michael Gozin In vitro synthesis of uniform poly(dG... 3-5' exo,5-3' exo,All properties
2005 Kristi Kincaid, Jeff W Beckman, Aleksandra Zivkovic, Randall L Halcomb, Joachim W Engels, Robert D Kuchta Exploration of factors driving incorp...
2005 JP Gill, Louis J Romano Mechanism for N-acetyl-2-aminofluoren...
2004 Kazuki Tainaka, Akimitsu Okamoto, Isao Saito Development of a novel solvatochromic...
2004 Muhammed F Hashim, James N Riggins, Nathalie Schnetz-Boutaud, Markus W Voehler, Michael P Stone, Lawrence J Marnett In vitro bypass of malondialdehyde-de...
2004 Michael B Doughty, Karam Aboudehen, Garland Anderson, Ke Li, Bob Moore, Tina Poolson Side-chain conformational restriction...
2004 Aviva S Meyer, Maureen Blandino, Thomas E Spratt Escherichia coli DNA polymerase I (Kl...
2004 C X Wang, E Zakharova, Jinming Li, Catherine M Joyce, Jianhong Wang, William H Konigsberg Pre-steady-state kinetics of RB69 DNA... kcat,All properties
2003 Vandana Purohit, Nigel D F Grindley, Catherine M Joyce Use of 2-aminopurine fluorescence to ...
2003 Lisa S Chen, Michael H Bahr, Terry L Sheppard Effects of 8-chlorodeoxyadenosine on ...
2003 Aashish Srivastava, Kamalendra Singh, Mukund J Modak Phe 771 of Escherichia coli DNA polym...
2003 Kamalendra Singh, Mukund J Modak Presence of 18-A long hydrogen bond t...
2003 Alexander Krieg, Stephan Laib, Thomas Ruckstuhl, Stefan Seeger Real-time detection of nucleotide inc...
2003 Robert M Turner, Nigel D F Grindley, Catherine M Joyce Interaction of DNA polymerase I (Klen...
2003 Victoria H Harris, Clifford L Smith, W Jonathan Cummins, Alan L Hamilton, David P Hornby, David M Williams Recognition of base-pairing by DNA po...
2003 Molly Chiaramonte, Chad L Moore, Kristi Kincaid, Robert D Kuchta Facile polymerization of dNTPs bearin...
2003 Olga Kornyushyna, Cynthia J Burrows Effect of the oxidized guanosine lesi...
2002 Olga Kornyushyna, Aym M Berges, James G Muller, Cynthia J Burrows In vitro nucleotide misinsertion oppo...
2002 Elizabeth H Z Thompson, Michael F Bailey, Edwin J C Van der Schans, Catherine M Joyce, David P Millar Determinants of DNA mismatch recognit...
2002 Vineeta Khare, Kristin A Eckert The proofreading 3'-->5' exonuclease ... 3-5' exo,5-3' exo,All properties
2002 Yuriy O Alekseyev, Louis J Romano Effects of benzo[a]pyrene adduct ster...
2002 Olga Potapova, Nigel D F Grindley, Catherine M Joyce The mutational specificity of the Dbh... Overall Error Rate,All properties
2002 Rajiv Gangurde, Mukund J Modak Participation of active-site carboxyl...
2002 Wai-Chung Lam, Elizabeth H Z Thompson, Olga Potapova, Xiaojun Chen Sun, Catherine M Joyce, David P Millar 3'-5' exonuclease of Klenow fragment:... 3-5' exo,5-3' exo,All properties
2001 Emmanuelle Delagoutte, Peter H von Hippel Molecular mechanisms of the functiona...
2001 I Terashima, Toshiro Matsuda, T W Fang, Naomi Suzuki, J Kobayashi, K Kohda, Shinya Shibutani Miscoding potential of the N2-ethyl-2... 3-5' exo,5-3' exo,All properties
2001 Holly H Hogrefe, J Cline, A E Lovejoy, K B Nielson DNA polymerases from hyperthermophiles. RT,Specific Activity,Processivity,Strand Displacement,3-5' exo,5-3' exo,KM,kcat,3-5' Exo Specific Activity,All properties
2001 P Zhuang, Alexander Kolbanovskiy, Shantu Amin, Nicholas E Geacintov Base sequence dependence of in vitro ...
2001 Manabu Yasui, S Matsui, M Ihara, Y R Laxmi, Shinya Shibutani, Toshiro Matsuda Translesional synthesis on a DNA temp...
2001 Thomas E Spratt Identification of hydrogen bonds betw...
2001 Yuriy O Alekseyev, Leonid Dzantiev, Louis J Romano Effects of benzo[a]pyrene DNA adducts...
2001 T C Lin, C X Wang, Catherine M Joyce, William H Konigsberg 3'-5' Exonucleolytic activity of DNA ...
2000 J C Morales, Eric T Kool Importance of terminal base pair hydr...
2000 D S Johnston, Michael P Stone Replication of a site-specific trans-...
2000 Yuriy O Alekseyev, Louis J Romano In vitro replication of primer-templa...
2000 Steven Tuske, Kamalendra Singh, Neerja Kaushik, Mukund J Modak The J-helix of Escherichia coli DNA p...
2000 Rajiv Gangurde, Neerja Kaushik, Kamalendra Singh, Mukund J Modak A carboxylate triad is essential for ...
2000 T V Rao, M T Haber, Jane M Sayer, Donald M Jerina Incorporation of 4-thiothymidine into...
2000 Leonid Dzantiev, Louis J Romano A conformational change in E. coli DN...
2000 Leonid Dzantiev, Louis J Romano Differential effects of N-acetyl-2-am...
2000 E F da Silva, Linda J Reha-Krantz Dinucleotide repeat expansion catalyz...
1999 Wai-Chung Lam, Edwin J C Van der Schans, L C Sowers, David P Millar Interaction of DNA polymerase I (Klen...
1999 C A Brautigam, K Aschheim, Thomas A Steitz Structural elucidation of the binding... Other Important Residues,All properties
1999 C A Brautigam, Siyang Sun, J A Piccirilli, Thomas A Steitz Structures of normal single-stranded ...
1999 Olga Rechkoblit, Shantu Amin, Nicholas E Geacintov Primer length dependence of binding o...
1999 Leonid Dzantiev, Louis J Romano Interaction of Escherichia coli DNA p...
1999 Dana T Minnick, Katarzyna Bebenek, Wendy P Osheroff, Robert M Turner, Mekbib Astatke, Lingfeng Liu, Thomas A Kunkel, Catherine M Joyce Side chains that influence fidelity a...
1998 Wai-Chung Lam, Edwin J C Van der Schans, Catherine M Joyce, David P Millar Effects of mutations on the partition...
1998 Mekbib Astatke, K Ng, Nigel D F Grindley, Catherine M Joyce A single side chain prevents Escheric...
1998 W S Furey, Catherine M Joyce, M A Osborne, D Klenerman, J A Peliska, S Balasubramanian Use of fluorescence resonance energy ...
1998 T E Carver, David P Millar Recognition of sequence-directed DNA ...
1998 A A Purmal, J P Bond, B A Lyons, Y W Kow, Susan S Wallace Uracil glycol deoxynucleoside triphos...
1998 Toshinori Suzuki, Masaru Yoshida, Masami Yamada, Hiroshi Ide, M Kobayashi, K Kanaori, K Tajima, K Makino Misincorporation of 2'-deoxyoxanosine...
1998 Yoshiyuki Mizushina, T Ueno, Y Goto, Y Isobe, M Sako, T Fujita, Kouji Hirota, H Hayashi, Kengo Sakaguchi Carboxyflavins, novel inhibitors of T...
1998 Olga I Lavrik, Heinz Peter Nasheuer, Klaus Weisshart, M S Wold, Rajendra Prasad, William A Beard, Samuel H Wilson, Alain Favre Subunits of human replication protein...
1998 Mekbib Astatke, Nigel D F Grindley, Catherine M Joyce How E. coli DNA polymerase I (Klenow ...
1998 M J Guo, S Hildbrand, C J Leumann, L W McLaughlin, M J Waring Inhibition of DNA polymerase reaction...
1998 S W Graves, Allison A Johnson, Kenneth A Johnson Expression, purification, and initial... Processivity,Kd,Vmax,All properties
1998 James R Kiefer, C Mao, J C Braman, Lorena S Beese Visualizing DNA replication in a cata... Specific Activity,Processivity,3-5' exo,KM,kcat,Polymerase Catalytic Residue Amino Acids,Residues Involved in Catalysis of 3-5' Exo,All properties
1997 E Bedford, Stanley Tabor, Charles C Richardson The thioredoxin binding domain of bac... Specific Activity,Processivity,All properties
1997 Thomas E Spratt Klenow fragment-DNA interaction requi...
1997 Marc M Greenberg, T J Matray Inhibition of klenow fragment (exo-) ...
1997 Holly Miller, Arthur P Grollman Kinetics of DNA polymerase I (Klenow ... Template lesions,All properties
1996 Dana T Minnick, Mekbib Astatke, Catherine M Joyce, Thomas A Kunkel A thumb subdomain mutant of the large... Cloned or native,Tagged,Full length or truncated,Frameshift Error Rate,Nucleotide Substitution Rate,KM,Kd,kcat,Molecular Weight,Overall Error Rate,All properties
1996 B M Moore, R K Jalluri, Michael B Doughty DNA polymerase photoprobe 2-[(4-azido...
1996 J S King, C F Fairley, W F Morgan DNA end joining by the Klenow fragmen...
1996 B M Moore, Ke Li, Michael B Doughty Deoxyadenosine-based DNA polymerase p...
1996 T I Kolocheva, A S Levina, G A Nevinsky Recognition of the primers containing...
1996 M W Frey, S T Frey, W D Horrocks, B F Kaboord, Stephen J Benkovic Elucidation of the metal-binding prop...
1995 Mekbib Astatke, Nigel D F Grindley, Catherine M Joyce Deoxynucleoside triphosphate and pyro...
1995 Hiroyuki Kamiya, Hironori Kasai Formation of 2-hydroxydeoxyadenosine ... KM,Vmax,All properties
1995 M W Frey, L C Sowers, David P Millar, Stephen J Benkovic The nucleotide analog 2-aminopurine a...
1995 Hiroyuki Kamiya, Tadamasa Ueda, T Ohgi, Akio Matsukage, Hironori Kasai Misincorporation of dAMP opposite 2-h...
1995 R Doisy, M S Tang Effect of aminofluorene and (acetylam...
1995 Catherine M Joyce, V Derbyshire Purification of Escherichia coli DNA ...
1995 V Derbyshire, J K Pinsonneault, Catherine M Joyce Structure-function analysis of 3'-->5...
1995 Katarzyna Bebenek, Thomas A Kunkel Analyzing fidelity of DNA polymerases. Frameshift Error Rate,Overall Error Rate,All properties
1995 Stephen J Benkovic, Craig E Cameron Kinetic analysis of nucleotide incorp...
1995 T J Matray, K J Haxton, Marc M Greenberg The effects of the ring fragmentation...
1994 T C Lin, G Karam, William H Konigsberg Isolation, characterization, and kine... KM,kcat,All properties
1994 T E Carver, R A Hochstrasser, David P Millar Proofreading DNA: recognition of aber...
1994 A A Purmal, Y W Kow, Susan S Wallace 5-Hydroxypyrimidine deoxynucleoside t...
1994 J G Hacia, P B Dervan, B J Wold Inhibition of Klenow fragment DNA pol...
1994 F J Wang, L S Ripley DNA sequence effects on single base d...
1994 D Simha, D Yadav, R W Rzepka, V A Palejwala, M Zafri Humayun Base incorporation and extension at a...
1994 P N Yadav, J S Yadav, Edward Arnold, Mukund J Modak A computer-assisted analysis of conse...
1993 Kristin A Eckert, Thomas A Kunkel Fidelity of DNA synthesis catalyzed b...
1993 A T Bankier Dideoxy sequencing reactions using Kl...
1993 Lorena S Beese, J M Friedman, Thomas A Steitz Crystal structures of the Klenow frag... Amino Acids Contacting NTP,All properties
1993 Lorena S Beese, V Derbyshire, Thomas A Steitz Structure of DNA polymerase I Klenow ... Amino Acids Contacting Template,Residues Involved in Catalysis of 3-5' Exo,Other Important Residues,All properties
1993 Thomas A Steitz, S Smerdon, J Jäger, Jianhong Wang, L A Kohlstaedt, J M Friedman, Lorena S Beese, P A Rice Two DNA polymerases: HIV reverse tran...
1993 H Kong, R B Kucera, William E Jack Characterization of a DNA polymerase ... Processivity,KM,All properties
1993 Linda B Bloom, M R Otto, J M Beechem, Myron F Goodman Influence of 5'-nearest neighbors on ...
1993 V Derbyshire, Mekbib Astatke, Catherine M Joyce Re-engineering the polymerase domain ...
1993 H P Rappaport Replication of the base pair 6-thiogu...
1993 W E Schy, L W Hertel, J S Kroin, Linda B Bloom, Myron F Goodman, Frank C Richardson Effect of a template-located 2',2'-di...
1992 P N Yadav, J S Yadav, Mukund J Modak A molecular model of the complete thr...
1992 M V Ljach, T I Kolocheva, V V Gorn, A S Levina, G A Nevinsky The affinity of the Klenow fragment o...
1992 Daekyu Sun, Laurence H Hurley Effect of the (+)-CC-1065-(N3-adenine...
1992 M Bakhanashvili, A Hizi Fidelity of the reverse transcriptase... RT,3-5' exo,All properties
1992 Catherine M Joyce, Xiaojun Chen Sun, Nigel D F Grindley Reactions at the polymerase active si...
1992 Linda J Reha-Krantz Are there highly conserved DNA polyme...
1991 M E Dahlberg, Stephen J Benkovic Kinetic mechanism of DNA polymerase I...
1991 G del Solar, M Espinosa Labelling DNA ends with the Klenow fr...
1991 Steven S Carroll, M Cowart, Stephen J Benkovic A mutant of DNA polymerase I (Klenow ...
1991 I A Lokhova, G A Nevinsky, T S Godovikova, E M Ivanova, A A Koshkin, D S Sergeev, E I Frolova, N K Rudenko, V V Khomov, V M Kavsan 5'-derivatives of oligonucleotides as...
1991 Lorena S Beese, Thomas A Steitz Structural basis for the 3'-5' exonuc... Residues Involved in Catalysis of 3-5' Exo,Other Important Residues,All properties
1991 B T Eger, Robert D Kuchta, Steven S Carroll, P A Benkovic, M E Dahlberg, Catherine M Joyce, Stephen J Benkovic Mechanism of DNA replication fidelity...
1991 C R Guest, R A Hochstrasser, C G Dupuy, D J Allen, Stephen J Benkovic, David P Millar Interaction of DNA with the Klenow fr...
1991 V Derbyshire, Nigel D F Grindley, Catherine M Joyce The 3'-5' exonuclease of DNA polymera... Cloned or native,Tagged,Full length or truncated,Specific Activity,3-5' exo,KM,kcat,All properties
1991 T K McDaniel, Y Huang, Jun Yin, S W Needleman, S J Meltzer Direct radioactive labeling of unpuri...
1990 J Rush, William H Konigsberg Photoaffinity labeling of the Klenow ...
1990 I A Potapova, G A Nevinsky, V V Khomov, Olga I Lavrik NaF and mononucleotides as inhibitors...
1990 A H Polesky, Thomas A Steitz, Nigel D F Grindley, Catherine M Joyce Identification of residues critical f... 3-5' exo,Molecular Weight,All properties
1990 M K Dosanjh, John M Essigmann, Myron F Goodman, B Singer Comparative efficiency of forming m4T...
1990 Katarzyna Bebenek, Catherine M Joyce, M P Fitzgerald, Thomas A Kunkel The fidelity of DNA synthesis catalyz... 3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,Residues Involved in Catalysis of 3-5' Exo,All properties
1990 I A Potapova, G A Nevinsky, A G Veniaminova, V V Khomov, Olga I Lavrik Interaction of dNTP, pyrophosphate an...
1990 Vladimir N Podust, T O Korobeinicheva, G A Nevinsky, A S Levina, Olga I Lavrik Inactivation of DNA polymerase by ade...
1990 G A Nevinskiĭ, I A Potapova, N B Tarusova, O V Khalabuda, V V Khomov [Interaction of dNTP-binding sites of...
1989 S V Doronin, G A Nevinsky, T O Malygina, Vladimir N Podust, V V Khomov, Olga I Lavrik The efficiency of interaction of deox...
1989 D J Allen, P L Darke, Stephen J Benkovic Fluorescent oligonucleotides and deox...
1989 B Singer, F Chavez, S J Spengler, J T Kuśmierek, L Mendelman, Myron F Goodman Comparison of polymerase insertion an...
1989 C E Catalano, Stephen J Benkovic Inactivation of DNA polymerase I (Kle...
1989 G A Nevinsky, A V Nemudraya, A S Levina, V V Khomov The algorithm of estimation of the Km...
1989 D J Allen, Stephen J Benkovic Resonance energy transfer measurement...
1989 T A Rozovskaia, Sh Kh Minasian, M K Kukhanova, A A Kraevskiĭ, Z G Chidzhavadze [DNA polymerase I, Klenow fragment of...
1989 C Papanicolaou, L S Ripley Polymerase-specific differences in th... Overall Error Rate,All properties
1989 P Keohavong, William G Thilly Fidelity of DNA polymerases in DNA am... Nucleotide Substitution Rate,All properties
1989 Katarzyna Bebenek, Thomas A Kunkel The use of native T7 DNA polymerase f...
1988 H M Lim, J J Pène Optimal conditions for supercoil DNA ...
1988 V Derbyshire, P S Freemont, M R Sanderson, L Beese, J M Friedman, Catherine M Joyce, Thomas A Steitz Genetic and crystallographic studies ... Cloned or native,Tagged,Full length or truncated,Specific Activity,Residues Involved in Catalysis of 3-5' Exo,Other Important Residues,All properties
1988 P S Freemont, J M Friedman, Lorena S Beese, M R Sanderson, Thomas A Steitz Cocrystal structure of an editing com... Residues Involved in Catalysis of 3-5' Exo,Other Important Residues,All properties
1988 K R Tindall, Thomas A Kunkel Fidelity of DNA synthesis by the Ther... Full length or truncated,3-5' exo,Nucleotide Substitution Rate,Overall Error Rate,All properties
1988 R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich Primer-directed enzymatic amplificati... Nucleotide Substitution Rate,All properties
1988 P Keohavong, A G Kat, N F Cariello, William G Thilly DNA amplification in vitro using T4 D...
1987 Thomas A Steitz, L Beese, P S Freemont, J M Friedman, M R Sanderson Structural studies of Klenow fragment...
1987 M S Krug, S L Berger First-strand cDNA synthesis primed wi...
1986 P S Freemont, David L Ollis, Thomas A Steitz, Catherine M Joyce A domain of the Klenow fragment of Es...
1986 Thomas A Steitz, P S Freemont, David L Ollis, Catherine M Joyce, J M Grindley Functional implications of the Klenow...
1985 David L Ollis, C Kline, Thomas A Steitz Domain of E. coli DNA polymerase I sh...
1985 David L Ollis, P Brick, R Hamlin, N G Xuong, Thomas A Steitz Structure of large fragment of Escher... Cloned or native,Tagged,Full length or truncated,Other Important Residues,All properties
1984 A P Gupta, P A Benkovic, Stephen J Benkovic The effect of the 3',5' thiophosphory...
1984 V Bailly, W G Verly The excision of AP sites by the 3'-5'...
1983 Catherine M Joyce, Nigel D F Grindley Construction of a plasmid that overpr... Cloned or native,All properties
1972 D Brutlag, Arthur Kornberg Enzymatic synthesis of deoxyribonucle... Vmax,All properties
1972 P Setlow, D Brutlag, Arthur Kornberg Deoxyribonucleic acid polymerase: two... Specific Activity,Extinction Coefficient,3-5' exo,5-3' exo,Molecular Weight,All properties
1972 P Setlow, Arthur Kornberg Deoxyribonucleic acid polymerase: two... 3-5' exo,5-3' exo,Molecular Weight,All properties
1970 H Klenow, I Henningsen Selective elimination of the exonucle... Cloned or native,Tagged,Specific Activity,5-3' exo,Molecular Weight,All properties

Version:20250305