Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template.

Abstract:

Steady state kinetics and inhibition by a dipyridodiazepinone of the ...

Polymerases:

Topics:

Kinetic Parameters

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. KM 10nM Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. KM 40nM Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. KM 20nM Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. KM 100nM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. kcat 0.5 /minute Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. kcat 0.43 /minute Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. kcat 0.12 /minute Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State
HIV RT Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template. kcat 0.77 /minute Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State

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