Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Rao A, Balzarini J, Carbone A, Chimirri A, De Clercq E, Monforte AM, Monforte P, Pannecouque C, Zappalà M
Farmaco (Società chimica italiana : 1989) (2004), Volume 59, Page 33
PubMed entry

Abstract:

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and ...
Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

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HIV RT

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