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Pannecouque C

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Publications:

Title Authors Year Journal
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2013 European journal of medicinal chemistry
N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase. Pannecouque C 2013 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs. Pannecouque C 2013 Bioorganic & medicinal chemistry
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors. Pannecouque C 2013 ChemMedChem
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies. Pannecouque C 2013 Bioorganic & medicinal chemistry
Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate-Early 2 Protein, a Promising Target for Anti-HCMV Treatment. Pannecouque C 2013 ChemMedChem
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2013 Bioorganic & medicinal chemistry letters
Design, Synthesis, and Biological Evaluation of Novel 3,5-Disubstituted-1,2,6-Thiadiazine-1,1-Dione Derivatives as HIV-1 NNRTIs. Pannecouque C 2013 Chemical biology & drug design
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2012 European journal of medicinal chemistry
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs. Pannecouque C 2012 Bioorganic & medicinal chemistry letters
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2012 Bioorganic & medicinal chemistry
Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-Triazole Thioacetanilide Derivatives as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Pannecouque C 2012 Medicinal chemistry (Shāriqah (United Arab Emirates))
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2012 European journal of medicinal chemistry
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors. Pannecouque C 2012 European journal of medicinal chemistry
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach. Pannecouque C 2012 Bioorganic & medicinal chemistry
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. Pannecouque C 2011 Journal of medicinal chemistry
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2011 Bioorganic & medicinal chemistry
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2011 ChemMedChem
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents. Pannecouque C 2011 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. Pannecouque C 2011 ChemMedChem
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2010 Bioorganic & medicinal chemistry
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2010 Bioorganic & medicinal chemistry
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy. Pannecouque C 2010 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV. Pannecouque C 2010 Bioorganic & medicinal chemistry
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Pannecouque C 2010 ChemMedChem
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors. Pannecouque C 2010 Chemistry & biodiversity
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2009 European journal of medicinal chemistry
Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents. Pannecouque C 2009 Archiv der Pharmazie
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2009 European journal of medicinal chemistry
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation. Pannecouque C 2009 Bioorganic & medicinal chemistry
Design strategies of novel NNRTIs to overcome drug resistance. Pannecouque C 2009 Current medicinal chemistry
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines. Pannecouque C 2009 Yao xue xue bao = Acta pharmaceutica Sinica
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain. Pannecouque C 2009 Chemistry & biodiversity
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2009 European journal of medicinal chemistry
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Pannecouque C 2009 J Med Chem
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Pannecouque C 2009 ChemMedChem
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. Pannecouque C 2009 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2009 Bioorganic & medicinal chemistry
Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Pannecouque C 2008 Bioorganic & medicinal chemistry letters
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2008 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2008 Bioorganic & medicinal chemistry
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues. Pannecouque C 2008 Chemistry & biodiversity
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity. Pannecouque C 2008 European journal of medicinal chemistry
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2008 Bioorganic & medicinal chemistry letters
2-(2,6-Dihalo-phenyl)-3-heteroaryl-2-ylmethyl-1, 3-thiazolidin-4-ones: anti-HIV agents. Pannecouque C 2008 Chemical biology & drug design
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents. Pannecouque C 2008 European journal of medicinal chemistry
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. Pannecouque C 2008 Bioorganic & medicinal chemistry letters
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs). Pannecouque C 2008 Bioorganic & medicinal chemistry
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs. Pannecouque C 2007 Molecules (Basel, Switzerland)
Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways. Pannecouque C 2007 Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. Pannecouque C 2007 Journal of medicinal chemistry
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2007 Journal of medicinal chemistry
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2007 European journal of medicinal chemistry
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV. Pannecouque C 2007 Nucleosides, nucleotides & nucleic acids
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. Pannecouque C 2007 Bioorganic & medicinal chemistry letters
Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives. Pannecouque C 2007 Acta pharmaceutica (Zagreb, Croatia)
Nitroimidazoles Part 6. Synthesis, structure and in vitro anti-HIV activity of new 5-substituted piperazinyl-4-nitroimidazole derivatives. Pannecouque C 2007 Antiviral chemistry & chemotherapy
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents. Pannecouque C 2007 Medicinal chemistry (Shāriqah (United Arab Emirates))
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. Pannecouque C 2007 Journal of medicinal chemistry
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents. Pannecouque C 2007 Bioorganic & medicinal chemistry
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. Pannecouque C 2006 Bioorganic & medicinal chemistry
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. Pannecouque C 2006 Journal of medicinal chemistry
Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles. Pannecouque C 2006 Chemistry & biodiversity
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues. Pannecouque C 2006 Chemical & pharmaceutical bulletin
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives. Pannecouque C 2006 Chemical & pharmaceutical bulletin
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action. Pannecouque C 2005 The Journal of antimicrobial chemotherapy
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. Pannecouque C 2005 Journal of the American Chemical Society
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues. Pannecouque C 2005 Chemical & pharmaceutical bulletin
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues. Pannecouque C 2005 Archiv der Pharmazie
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. Pannecouque C 2005 Journal of medicinal chemistry
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2005 Journal of medicinal chemistry
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. Pannecouque C 2005 Journal of virology
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors. Pannecouque C 2004 Journal of medicinal chemistry
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents. Pannecouque C 2004 Farmaco (Società chimica italiana : 1989)
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series. Pannecouque C 2004 Bioorganic & medicinal chemistry letters
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2004 Antiviral research
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones. Pannecouque C 2004 Bioorganic chemistry
Novel inhibitors of HIV-1 integration. Pannecouque C 2004 Current drug metabolism
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. Pannecouque C 2003 Journal of medicinal chemistry
Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry. Pannecouque C 2003 Antiviral chemistry & chemotherapy
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues. Pannecouque C 2003 Chemical & pharmaceutical bulletin
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives. Pannecouque C 2003 Antimicrobial agents and chemotherapy
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV. Pannecouque C 2003 Antiviral chemistry & chemotherapy
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action. Pannecouque C 2003 Antimicrobial agents and chemotherapy
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Pannecouque C 2002 Antimicrobial agents and chemotherapy
New class of HIV integrase inhibitors that block viral replication in cell culture. Pannecouque C 2002 Current biology : CB
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors. Pannecouque C 2001 Antiviral chemistry & chemotherapy
Anti-HIV-1 activity of benzothiadiazine dioxide. Pannecouque C 2001 Antiviral chemistry & chemotherapy
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues. Pannecouque C 2000 Antimicrobial agents and chemotherapy
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. Pannecouque C 2000 Molecular pharmacology
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. Pannecouque C 2000 Bioorganic & medicinal chemistry
In vitro evaluation of the effect of temporary removal of HIV drug pressure. Pannecouque C 2000 Antiviral research
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs. Pannecouque C 2000 Methods in molecular medicine
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. Pannecouque C 1999 AIDS (London, England)
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors. Pannecouque C 1999 Bioorganic & medicinal chemistry
Inhibition of human immunodeficiency virus type (HIV-1) replication by some diversely functionalized spirocyclopropyl derivatives. Pannecouque C 1999 Archiv der Pharmazie
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity. Pannecouque C 1998 Antimicrobial agents and chemotherapy
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication. Pannecouque C 1998 Journal of medicinal chemistry
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Pannecouque C 1997 Antimicrobial agents and chemotherapy
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