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Balzarini J

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Title Authors Year Journal
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase. Balzarini J Nucleosides, nucleotides & nucleic acids
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs. Balzarini J 2013 Bioorganic & medicinal chemistry
N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase. Balzarini J 2013 Bioorganic & medicinal chemistry
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Balzarini J 2013 Bioorganic & medicinal chemistry letters
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies. Balzarini J 2013 Bioorganic & medicinal chemistry
Design, Synthesis, and Biological Evaluation of Novel 3,5-Disubstituted-1,2,6-Thiadiazine-1,1-Dione Derivatives as HIV-1 NNRTIs. Balzarini J 2013 Chemical biology & drug design
A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity. Balzarini J 2013 PLoS pathogens
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors. Balzarini J 2013 ChemMedChem
Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-Triazole Thioacetanilide Derivatives as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Balzarini J 2012 Medicinal chemistry (Shāriqah (United Arab Emirates))
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Balzarini J 2012 Antimicrobial agents and chemotherapy
In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs. Balzarini J 2012 Journal of virology
Potential of carbohydrate-binding agents as therapeutics against enveloped viruses. Balzarini J 2012 Medicinal research reviews
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Balzarini J 2012 European journal of medicinal chemistry
Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications. Balzarini J 2012 Current pharmaceutical design
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2012 European journal of medicinal chemistry
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors. Balzarini J 2011 ChemMedChem
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Balzarini J 2011 Cell host & microbe
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. Balzarini J 2011 Journal of medicinal chemistry
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. Balzarini J 2011 Journal of medicinal chemistry
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. Balzarini J 2011 Journal of medicinal chemistry
Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides. Balzarini J 2011 Antiviral research
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents. Balzarini J 2011 Bioorganic & medicinal chemistry
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV. Balzarini J 2010 Bioorganic & medicinal chemistry
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Balzarini J 2010 ChemMedChem
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors. Balzarini J 2010 Bioorganic & medicinal chemistry
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy. Balzarini J 2010 Bioorganic & medicinal chemistry
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. Balzarini J 2010 The Journal of biological chemistry
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines. Balzarini J 2009 Yao xue xue bao = Acta pharmaceutica Sinica
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus. Balzarini J 2009 Journal of medicinal chemistry
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. Balzarini J 2009 The Journal of biological chemistry
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. Balzarini J 2009 Journal of medicinal chemistry
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Balzarini J 2009 ChemMedChem
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2009 European journal of medicinal chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain. Balzarini J 2009 Chemistry & biodiversity
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues. Balzarini J 2008 Chemistry & biodiversity
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Balzarini J 2008 Cell Host Microbe
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. Balzarini J 2008 Journal of medicinal chemistry
Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity. Balzarini J 2008 Antimicrobial agents and chemotherapy
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2008 Bioorganic & medicinal chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity. Balzarini J 2008 European journal of medicinal chemistry
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV. Balzarini J 2007 Nucleosides, nucleotides & nucleic acids
Comparative evaluation of the activity of antivirals towards feline immunodeficiency virus in different cell culture systems. Balzarini J 2007 Antiviral research
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2007 Journal of medicinal chemistry
Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones. Balzarini J 2007 European journal of medicinal chemistry
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. Balzarini J 2007 Bioorganic & medicinal chemistry letters
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2007 European journal of medicinal chemistry
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships. Balzarini J 2007 Nucleosides, nucleotides & nucleic acids
Therapeutic strategies towards HIV-1 infection in macrophages. Balzarini J 2006 Antiviral research
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives. Balzarini J 2006 Chemical & pharmaceutical bulletin
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. Balzarini J 2006 Journal of medicinal chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues. Balzarini J 2006 Chemical & pharmaceutical bulletin
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. Balzarini J 2005 Journal of virology
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. Balzarini J 2005 Journal of medicinal chemistry
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A. Balzarini J 2005 Molecular pharmacology
The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations. Balzarini J 2005 Journal of the American Chemical Society
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. Balzarini J 2005 FEBS letters
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Balzarini J 2005 Molecular pharmacology
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides. Balzarini J 2005 Antimicrobial agents and chemotherapy
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Balzarini J 2005 Antimicrobial agents and chemotherapy
Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis. Balzarini J 2005 Molecular pharmacology
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action. Balzarini J 2005 The Journal of antimicrobial chemotherapy
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues. Balzarini J 2005 Chemical & pharmaceutical bulletin
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues. Balzarini J 2005 Archiv der Pharmazie
Antiviral profile of HIV inhibitors in macrophages: implications for therapy. Balzarini J 2004 Current topics in medicinal chemistry
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT. Balzarini J 2004 Journal of virology
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones. Balzarini J 2004 Bioorganic chemistry
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2004 Antiviral research
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series. Balzarini J 2004 Bioorganic & medicinal chemistry letters
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase. Balzarini J 2004 Current topics in medicinal chemistry
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. Balzarini J 2004 Current topics in medicinal chemistry
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents. Balzarini J 2004 Farmaco (Società chimica italiana : 1989)
Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors. Balzarini J 2004 Molecular pharmacology
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Balzarini J 2004 Antimicrobial agents and chemotherapy
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude. Balzarini J 2003 Journal of medicinal chemistry
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors. Balzarini J 2003 Antiviral chemistry & chemotherapy
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. Balzarini J 2003 Journal of medicinal chemistry
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV. Balzarini J 2003 Antiviral chemistry & chemotherapy
Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription. Balzarini J 2003 Journal of medicinal chemistry
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues. Balzarini J 2003 Chemical & pharmaceutical bulletin
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives. Balzarini J 2003 Antimicrobial agents and chemotherapy
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action. Balzarini J 2003 Antimicrobial agents and chemotherapy
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues. Balzarini J 2003 Antiviral chemistry & chemotherapy
Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay. Balzarini J 2003 Nucleosides, nucleotides & nucleic acids
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues. Balzarini J 2003 Antiviral chemistry & chemotherapy
Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission. Balzarini J 2002 AIDS research and human retroviruses
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach. Balzarini J 2002 Journal of medicinal chemistry
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir. Balzarini J 2002 Antiviral research
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides. Balzarini J 2002 Biochimica et biophysica acta
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors. Balzarini J 2002 Molecular pharmacology
Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells. Balzarini J 2002 AIDS (London, England)
Anti-HIV-1 activity of benzothiadiazine dioxide. Balzarini J 2001 Antiviral chemistry & chemotherapy
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. Balzarini J 2001 Journal of medicinal chemistry
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. Balzarini J 2001 Bioorganic & medicinal chemistry letters
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138. Balzarini J 2001 Virology
Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT. Balzarini J 2001 Virology
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors. Balzarini J 2001 Antiviral chemistry & chemotherapy
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. Balzarini J 2001 Journal of virology
Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture. Balzarini J 2001 AIDS research and human retroviruses
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Balzarini J 2000 The Journal of biological chemistry
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients. Balzarini J 2000 AIDS research and human retroviruses
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine. Balzarini J 2000 Biochemistry
Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum. Balzarini J 2000 Parasitol Int
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes. Balzarini J 2000 The Biochemical journal
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors. Balzarini J 2000 Molecular pharmacology
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors. Balzarini J 2000 AIDS research and human retroviruses
Evaluation of Compounds Against Recombinant HIV Reverse Transcriptase. Balzarini J 2000 Methods in molecular medicine
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs. Balzarini J 2000 Methods in molecular medicine
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. Balzarini J 1999 Biochemical pharmacology
Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy. Balzarini J 1999 Biochemical pharmacology
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase. Balzarini J 1999 Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors. Balzarini J 1999 Bioorganic & medicinal chemistry
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region. Balzarini J 1999 Journal of medicinal chemistry
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase. Balzarini J 1998 Journal of medicinal chemistry
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication. Balzarini J 1998 Journal of medicinal chemistry
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity. Balzarini J 1998 Antimicrobial agents and chemotherapy
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Balzarini J 1998 Biochemistry
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. Balzarini J 1998 The Journal of general virology
An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Balzarini J 1998 Antiviral chemistry & chemotherapy
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Balzarini J 1998 Antiviral chemistry & chemotherapy
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer. Balzarini J 1997 Gene therapy
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. Balzarini J 1997 Journal of virology
Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine. Balzarini J 1997 The Journal of infectious diseases
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes. Balzarini J 1997 Journal of leukocyte biology
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. Balzarini J 1997 Biochemical and biophysical research communications
SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques. Balzarini J 1997 Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Balzarini J 1997 Antimicrobial agents and chemotherapy
Reverse transcriptase fidelity and HIV-1 variation. Balzarini J 1997 Science (New York, N.Y.)
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109. Balzarini J 1996 Biochemical and biophysical research communications
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Balzarini J 1996 Molecular pharmacology
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine. Balzarini J 1996 Molecular pharmacology
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Balzarini J 1996 Molecular pharmacology
A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. Balzarini J 1996 Journal of virological methods
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. Balzarini J 1996 Molecular pharmacology
Analysis of inhibition of retroviral reverse transcriptase. Balzarini J 1996 Methods in enzymology
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity. Balzarini J 1996 Antiviral research
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus. Balzarini J 1996 Antimicrobial agents and chemotherapy
Novel concepts in the treatment of human immunodeficiency virus type 1 (HIV-1) infections by HIV-1-specific reverse transcriptase inhibitors. Balzarini J 1995 Verhandelingen - Koninklijke Academie voor Geneeskunde van België
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase. Balzarini J 1995 Journal of medicinal chemistry
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains. Balzarini J 1995 Antimicrobial agents and chemotherapy
Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells. Balzarini J 1995 Biochemical pharmacology
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains. Balzarini J 1995 Antiviral research
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). Balzarini J 1995 Proceedings of the National Academy of Sciences of the United States of America
Knocking out human immunodeficiency virus through non-nucleoside reverse transcriptase inhibitors used as single agents or in combinations: a paradigm for the cure of AIDS? Balzarini J 1995 Farmaco (Società chimica italiana : 1989)
Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors. Balzarini J 1995 Biochemical and biophysical research communications
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. Balzarini J 1994 The Journal of biological chemistry
Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors. Balzarini J 1994 Biochemical and biophysical research communications
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells. Balzarini J 1994 Molecular pharmacology
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720. Balzarini J 1994 Journal of virology
The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates). Balzarini J 1994 Journal of medicinal chemistry
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants. Balzarini J 1994 Proceedings of the National Academy of Sciences of the United States of America
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues. Balzarini J 1993 Molecular pharmacology
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. Balzarini J 1993 Proceedings of the National Academy of Sciences of the United States of America
Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs. Balzarini J 1993 Antimicrobial agents and chemotherapy
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. Balzarini J 1993 Virology
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Balzarini J 1993 Virology
Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy. Balzarini J 1993 Journal of virology
Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. Balzarini J 1993 Molecular pharmacology
3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties. Balzarini J 1992 Journal of medicinal chemistry
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents. Balzarini J 1992 Molecular pharmacology
Selective inhibition of HIV replication by adriamycin in macrophages but not in lymphocytes. Balzarini J 1992 AIDS research and human retroviruses
Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes. Balzarini J 1992 Biochemical pharmacology
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T). Balzarini J 1992 The Journal of biological chemistry
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. Balzarini J 1992 Proceedings of the National Academy of Sciences of the United States of America
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1. Balzarini J 1992 Antimicrobial agents and chemotherapy
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. Balzarini J 1991 Proceedings of the National Academy of Sciences of the United States of America
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue. Balzarini J 1991 AIDS (London, England)
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Balzarini J 1991 Proceedings of the National Academy of Sciences of the United States of America
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives. Balzarini J 1991 The Journal of biological chemistry
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. Balzarini J 1990 Molecular pharmacology
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases. Balzarini J 1989 Molecular pharmacology
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. Balzarini J 1989 Biochemical and biophysical research communications
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid. Balzarini J 1988 European journal of biochemistry / FEBS
Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro. Balzarini J 1988 Biochemical and biophysical research communications
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Balzarini J 1988 Proceedings of the National Academy of Sciences of the United States of America
Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity. Balzarini J 1988 Biochemical pharmacology
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. Balzarini J 1986 Biochemical and biophysical research communications
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV). Balzarini J 1986 International journal of cancer. Journal international du cancer
Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine. Balzarini J 1983 The Biochemical journal
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