Balzarini J

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Title	Authors	Year	Journal
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase.	Balzarini J		Nucleosides, nucleotides & nucleic acids
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies.	Balzarini J	2013	Bioorganic & medicinal chemistry
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.	Balzarini J	2013	Bioorganic & medicinal chemistry letters
Design, Synthesis, and Biological Evaluation of Novel 3,5-Disubstituted-1,2,6-Thiadiazine-1,1-Dione Derivatives as HIV-1 NNRTIs.	Balzarini J	2013	Chemical biology & drug design
A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity.	Balzarini J	2013	PLoS pathogens
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors.	Balzarini J	2013	ChemMedChem
N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.	Balzarini J	2013	Bioorganic & medicinal chemistry
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.	Balzarini J	2013	Bioorganic & medicinal chemistry
Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.	Balzarini J	2012	Current pharmaceutical design
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2012	European journal of medicinal chemistry
Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-Triazole Thioacetanilide Derivatives as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.	Balzarini J	2012	Medicinal chemistry (Shāriqah (United Arab Emirates))
In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.	Balzarini J	2012	Journal of virology
Potential of carbohydrate-binding agents as therapeutics against enveloped viruses.	Balzarini J	2012	Medicinal research reviews
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.	Balzarini J	2012	Antimicrobial agents and chemotherapy
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.	Balzarini J	2012	European journal of medicinal chemistry
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.	Balzarini J	2011	Cell host & microbe
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.	Balzarini J	2011	Journal of medicinal chemistry
Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides.	Balzarini J	2011	Antiviral research
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.	Balzarini J	2011	Journal of medicinal chemistry
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents.	Balzarini J	2011	Bioorganic & medicinal chemistry
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors.	Balzarini J	2011	ChemMedChem
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.	Balzarini J	2011	Journal of medicinal chemistry
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.	Balzarini J	2010	Bioorganic & medicinal chemistry
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.	Balzarini J	2010	Bioorganic & medicinal chemistry
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.	Balzarini J	2010	ChemMedChem
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.	Balzarini J	2010	The Journal of biological chemistry
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.	Balzarini J	2010	Bioorganic & medicinal chemistry
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.	Balzarini J	2009	Journal of medicinal chemistry
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.	Balzarini J	2009	The Journal of biological chemistry
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2009	European journal of medicinal chemistry
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.	Balzarini J	2009	Journal of medicinal chemistry
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.	Balzarini J	2009	ChemMedChem
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.	Balzarini J	2009	Yao xue xue bao = Acta pharmaceutica Sinica
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.	Balzarini J	2009	Chemistry & biodiversity
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.	Balzarini J	2008	European journal of medicinal chemistry
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.	Balzarini J	2008	Cell Host Microbe
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues.	Balzarini J	2008	Chemistry & biodiversity
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2008	Bioorganic & medicinal chemistry
Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity.	Balzarini J	2008	Antimicrobial agents and chemotherapy
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action.	Balzarini J	2008	Journal of medicinal chemistry
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2007	European journal of medicinal chemistry
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships.	Balzarini J	2007	Nucleosides, nucleotides & nucleic acids
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.	Balzarini J	2007	Nucleosides, nucleotides & nucleic acids
Comparative evaluation of the activity of antivirals towards feline immunodeficiency virus in different cell culture systems.	Balzarini J	2007	Antiviral research
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.	Balzarini J	2007	Bioorganic & medicinal chemistry letters
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2007	Journal of medicinal chemistry
Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones.	Balzarini J	2007	European journal of medicinal chemistry
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.	Balzarini J	2006	Chemical & pharmaceutical bulletin
Therapeutic strategies towards HIV-1 infection in macrophages.	Balzarini J	2006	Antiviral research
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.	Balzarini J	2006	Journal of medicinal chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.	Balzarini J	2006	Chemical & pharmaceutical bulletin
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.	Balzarini J	2005	Chemical & pharmaceutical bulletin
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues.	Balzarini J	2005	Archiv der Pharmazie
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.	Balzarini J	2005	Journal of virology
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.	Balzarini J	2005	Journal of medicinal chemistry
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.	Balzarini J	2005	Molecular pharmacology
The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations.	Balzarini J	2005	Journal of the American Chemical Society
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs.	Balzarini J	2005	FEBS letters
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors.	Balzarini J	2005	Molecular pharmacology
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.	Balzarini J	2005	Antimicrobial agents and chemotherapy
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.	Balzarini J	2005	Antimicrobial agents and chemotherapy
Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.	Balzarini J	2005	Molecular pharmacology
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.	Balzarini J	2005	The Journal of antimicrobial chemotherapy
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.	Balzarini J	2004	Current topics in medicinal chemistry
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.	Balzarini J	2004	Antimicrobial agents and chemotherapy
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.	Balzarini J	2004	Journal of virology
Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors.	Balzarini J	2004	Molecular pharmacology
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.	Balzarini J	2004	Bioorganic chemistry
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2004	Antiviral research
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.	Balzarini J	2004	Bioorganic & medicinal chemistry letters
Antiviral profile of HIV inhibitors in macrophages: implications for therapy.	Balzarini J	2004	Current topics in medicinal chemistry
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase.	Balzarini J	2004	Current topics in medicinal chemistry
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.	Balzarini J	2004	Farmaco (Società chimica italiana : 1989)
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.	Balzarini J	2003	Antiviral chemistry & chemotherapy
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.	Balzarini J	2003	Antiviral chemistry & chemotherapy
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.	Balzarini J	2003	Journal of medicinal chemistry
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.	Balzarini J	2003	Journal of medicinal chemistry
Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay.	Balzarini J	2003	Nucleosides, nucleotides & nucleic acids
Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.	Balzarini J	2003	Journal of medicinal chemistry
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.	Balzarini J	2003	Chemical & pharmaceutical bulletin
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.	Balzarini J	2003	Antimicrobial agents and chemotherapy
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action.	Balzarini J	2003	Antimicrobial agents and chemotherapy
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.	Balzarini J	2003	Antiviral chemistry & chemotherapy
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues.	Balzarini J	2003	Antiviral chemistry & chemotherapy
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir.	Balzarini J	2002	Antiviral research
Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells.	Balzarini J	2002	AIDS (London, England)
Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission.	Balzarini J	2002	AIDS research and human retroviruses
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach.	Balzarini J	2002	Journal of medicinal chemistry
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides.	Balzarini J	2002	Biochimica et biophysica acta
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors.	Balzarini J	2002	Molecular pharmacology
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.	Balzarini J	2001	Journal of virology
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors.	Balzarini J	2001	Antiviral chemistry & chemotherapy
Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture.	Balzarini J	2001	AIDS research and human retroviruses
Anti-HIV-1 activity of benzothiadiazine dioxide.	Balzarini J	2001	Antiviral chemistry & chemotherapy
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.	Balzarini J	2001	Bioorganic & medicinal chemistry letters
Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT.	Balzarini J	2001	Virology
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.	Balzarini J	2001	Journal of medicinal chemistry
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.	Balzarini J	2001	Virology
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors.	Balzarini J	2000	Molecular pharmacology
Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum.	Balzarini J	2000	Parasitol Int
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.	Balzarini J	2000	AIDS research and human retroviruses
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.	Balzarini J	2000	The Journal of biological chemistry
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.	Balzarini J	2000	The Biochemical journal
Evaluation of Compounds Against Recombinant HIV Reverse Transcriptase.	Balzarini J	2000	Methods in molecular medicine
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.	Balzarini J	2000	Methods in molecular medicine
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine.	Balzarini J	2000	Biochemistry
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.	Balzarini J	2000	AIDS research and human retroviruses
Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy.	Balzarini J	1999	Biochemical pharmacology
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.	Balzarini J	1999	Bioorganic & medicinal chemistry
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region.	Balzarini J	1999	Journal of medicinal chemistry
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.	Balzarini J	1999	Biochemical pharmacology
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.	Balzarini J	1999	Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152.	Balzarini J	1998	The Journal of general virology
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.	Balzarini J	1998	Biochemistry
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).	Balzarini J	1998	Antiviral chemistry & chemotherapy
An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptase.	Balzarini J	1998	Antiviral chemistry & chemotherapy
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.	Balzarini J	1998	Journal of medicinal chemistry
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.	Balzarini J	1998	Journal of medicinal chemistry
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.	Balzarini J	1998	Antimicrobial agents and chemotherapy
Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine.	Balzarini J	1997	The Journal of infectious diseases
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.	Balzarini J	1997	Gene therapy
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes.	Balzarini J	1997	Journal of leukocyte biology
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives.	Balzarini J	1997	Biochemical and biophysical research communications
SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques.	Balzarini J	1997	Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.	Balzarini J	1997	Antimicrobial agents and chemotherapy
Reverse transcriptase fidelity and HIV-1 variation.	Balzarini J	1997	Science (New York, N.Y.)
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.	Balzarini J	1997	Journal of virology
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.	Balzarini J	1996	Biochemical and biophysical research communications
Analysis of inhibition of retroviral reverse transcriptase.	Balzarini J	1996	Methods in enzymology
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.	Balzarini J	1996	Molecular pharmacology
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine.	Balzarini J	1996	Molecular pharmacology
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus.	Balzarini J	1996	Antimicrobial agents and chemotherapy
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO).	Balzarini J	1996	Molecular pharmacology
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity.	Balzarini J	1996	Antiviral research
A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1.	Balzarini J	1996	Journal of virological methods
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.	Balzarini J	1996	Molecular pharmacology
Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells.	Balzarini J	1995	Biochemical pharmacology
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives).	Balzarini J	1995	Proceedings of the National Academy of Sciences of the United States of America
Knocking out human immunodeficiency virus through non-nucleoside reverse transcriptase inhibitors used as single agents or in combinations: a paradigm for the cure of AIDS?	Balzarini J	1995	Farmaco (Società chimica italiana : 1989)
Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors.	Balzarini J	1995	Biochemical and biophysical research communications
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.	Balzarini J	1995	Antiviral research
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.	Balzarini J	1995	Journal of medicinal chemistry
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains.	Balzarini J	1995	Antimicrobial agents and chemotherapy
Novel concepts in the treatment of human immunodeficiency virus type 1 (HIV-1) infections by HIV-1-specific reverse transcriptase inhibitors.	Balzarini J	1995	Verhandelingen - Koninklijke Academie voor Geneeskunde van België
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.	Balzarini J	1994	Journal of virology
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.	Balzarini J	1994	Proceedings of the National Academy of Sciences of the United States of America
The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates).	Balzarini J	1994	Journal of medicinal chemistry
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.	Balzarini J	1994	The Journal of biological chemistry
Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors.	Balzarini J	1994	Biochemical and biophysical research communications
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.	Balzarini J	1994	Molecular pharmacology
Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.	Balzarini J	1993	Antimicrobial agents and chemotherapy
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.	Balzarini J	1993	Virology
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors.	Balzarini J	1993	Proceedings of the National Academy of Sciences of the United States of America
Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy.	Balzarini J	1993	Journal of virology
Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.	Balzarini J	1993	Molecular pharmacology
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase.	Balzarini J	1993	Virology
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues.	Balzarini J	1993	Molecular pharmacology
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.	Balzarini J	1992	Proceedings of the National Academy of Sciences of the United States of America
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.	Balzarini J	1992	Antimicrobial agents and chemotherapy
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.	Balzarini J	1992	Molecular pharmacology
3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties.	Balzarini J	1992	Journal of medicinal chemistry
Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes.	Balzarini J	1992	Biochemical pharmacology
Selective inhibition of HIV replication by adriamycin in macrophages but not in lymphocytes.	Balzarini J	1992	AIDS research and human retroviruses
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).	Balzarini J	1992	The Journal of biological chemistry
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue.	Balzarini J	1991	AIDS (London, England)
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.	Balzarini J	1991	The Journal of biological chemistry
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.	Balzarini J	1991	Proceedings of the National Academy of Sciences of the United States of America
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.	Balzarini J	1991	Proceedings of the National Academy of Sciences of the United States of America
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.	Balzarini J	1990	Molecular pharmacology
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases.	Balzarini J	1989	Molecular pharmacology
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.	Balzarini J	1989	Biochemical and biophysical research communications
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid.	Balzarini J	1988	European journal of biochemistry / FEBS
Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro.	Balzarini J	1988	Biochemical and biophysical research communications
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.	Balzarini J	1988	Proceedings of the National Academy of Sciences of the United States of America
Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity.	Balzarini J	1988	Biochemical pharmacology
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV).	Balzarini J	1986	International journal of cancer. Journal international du cancer
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.	Balzarini J	1986	Biochemical and biophysical research communications
Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine.	Balzarini J	1983	The Biochemical journal

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Balzarini J

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