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Masutani C

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Publications:

Title Authors Year Journal
A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis. Masutani C 2013 Nucleic acids research
Structure and mechanism of human DNA polymerase η Masutani C 2011 Nature
Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer. Masutani C 2011 Nucleic acids research
Structure and mechanism of human DNA polymerase eta. Masutani C 2010 Nature
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. Masutani C 2010 PLoS genetics
The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. Masutani C 2010 Molecular cell
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. Masutani C 2010 Journal of nucleic acids
Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. Masutani C 2010 Carcinogenesis
Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. Masutani C 2009 DNA repair
A novel interaction between human DNA polymerase eta and MutLalpha. Masutani C 2009 Biochem Biophys Res Commun
Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus. Masutani C 2009 The Journal of biological chemistry
Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Masutani C 2009 Bioorganic & medicinal chemistry
Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta. Masutani C 2008 DNA repair
Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases. Masutani C 2008 Nucleic acids symposium series (2004)
Use of RNAi in C. elegans. Masutani C 2008 Methods in molecular biology (Clifton, N.J.)
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. Masutani C 2007 The Journal of biological chemistry
Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta. Masutani C 2007 Biochemistry
2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. Masutani C 2007 Biochemistry
A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. Masutani C 2007 The Journal of biological chemistry
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Masutani C 2006 Molecular and cellular biology
Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development. Masutani C 2006 Cell Struct Funct
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Masutani C 2006 Genes Cells
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Masutani C 2005 Proceedings of the National Academy of Sciences of the United States of America
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Masutani C 2005 Molecular cell
Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Masutani C 2005 The Journal of biological chemistry
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Masutani C 2004 Nature
Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa. Masutani C 2004 Biochemistry
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Masutani C 2004 Molecular and cellular biology
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Masutani C 2004 Nucleic acids research
High-efficiency bypass of DNA damage by human DNA polymerase Q. Masutani C 2004 The EMBO journal
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Masutani C 2004 Genes Cells
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. Masutani C 2003 EMBO reports
8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, 'action-at-a-distance' mutagenesis and inhibition of replication. Masutani C 2003 Nucleic acids research
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. Masutani C 2003 J Exp Med
Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. Masutani C 2003 The Journal of biological chemistry
Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. Masutani C 2002 The Journal of biological chemistry
[DNA polymerase eta: from a DNA repair-deficient genetic disease to the discovery of a novel DNA polymerase]. Masutani C 2002 Seikagaku
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Masutani C 2002 Proceedings of the National Academy of Sciences of the United States of America
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Masutani C 2002 Biochemistry
Proofreading of DNA polymerase eta-dependent replication errors. Masutani C 2001 The Journal of biological chemistry
Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. Masutani C 2001 The Journal of biological chemistry
Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota. Masutani C 2001 The Journal of biological chemistry
Error rate and specificity of human and murine DNA polymerase eta. Masutani C 2001 Journal of molecular biology
Low fidelity DNA synthesis by human DNA polymerase-eta. Masutani C 2000 Nature
Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Masutani C 2000 Genes Dev
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Masutani C 2000 Nucleic acids research
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Masutani C 2000 Biochemistry
Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Masutani C 2000 Oncogene
Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase. Masutani C 2000 Cold Spring Harbor symposia on quantitative biology
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. Masutani C 2000 The EMBO journal
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. Masutani C 1999 The EMBO journal
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Masutani C 1999 Nature
8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Masutani C 1995 Nucleic acids research
Stimulation of DNA synthesis by mouse DNA helicase B in a DNA replication system containing eukaryotic replication origins. Masutani C 1995 Biochemistry
Comparison of incorporation and extension of nucleotides in vitro opposite 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Masutani C 1995 Japanese journal of cancer research : Gann
Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Masutani C 1993 Nucleic acids research
Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. Masutani C 1991 Journal of virology
DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. Purification of the factor and analysis of the stimulation. Masutani C 1990 The Journal of biological chemistry
DNA primase-DNA polymerase alpha assembly from mouse FM3A cells. Purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis. Masutani C 1989 The Journal of biological chemistry

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