show help

Götte M

Author page

This page provides a summary of the entries in Polbase associated with this author.

The publication history graph presents the number of publications in Polbase by this author over time.

The polymerase chart indicates which polymerases this author has published on.

Polbase automatically discovers many polymerase papers as they are published. Some relevant papers are not included because the algorithm is designed to reduce background. Please contribute to polbase by adding your missing DNA polymerase papers.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Missing references?

Publications:

Title Authors Year Journal
Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. Götte M 2011 The Journal of biological chemistry
Effects of mutations F61A and A62V in the fingers subdomain of HIV-1 reverse transcriptase on the translocational equilibrium. Götte M 2011 Journal of molecular biology
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase. Götte M 2011 Antimicrobial agents and chemotherapy
Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition. Götte M 2011 The Journal of biological chemistry
Initiation of HIV reverse transcription: is enzyme flipping required? Götte M 2011 Viruses
HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy. Götte M 2010 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation. Götte M 2010 The Journal of biological chemistry
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions. Götte M 2010 Biochimica et biophysica acta
Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase. Götte M 2010 The Journal of infectious diseases
HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors. Götte M 2010 Viruses
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme. Götte M 2009 The Journal of biological chemistry
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. Götte M 2009 The Journal of biological chemistry
Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity. Götte M 2009 J Immunol
Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Götte M 2009 Carcinogenesis
Effect of testosterone on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitro. Götte M 2009 J Steroid Biochem Mol Biol
Stroke work or systolic dP/dtmax to evaluate acute response to cardiac resynchronization therapy: are they interchangeable? Götte M 2009 Eur J Heart Fail
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Götte M 2009 Nature structural & molecular biology
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. Götte M 2009 Journal of molecular biology
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Götte M 2008 ACS Chem Biol
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors". Götte M 2008 The Journal of biological chemistry
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. Götte M 2008 The Journal of biological chemistry
Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. Götte M 2008 J Pathol
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Götte M 2008 Cell Host Microbe
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids. Götte M 2008 Nucleic acids research
Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility. Götte M 2008 AIDS Rev
Microbial subversion of heparan sulfate proteoglycans. Götte M 2008 Mol Cells
Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome. Götte M 2008 Hum Mol Genet
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase. Götte M 2008 The Journal of biological chemistry
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Götte M 2007 Proceedings of the National Academy of Sciences of the United States of America
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. Götte M 2007 The Journal of biological chemistry
Insertions in the beta3-beta4 loop of reverse transcriptase of human immunodeficiency virus type 1 and their mechanism of action, influence on drug susceptibility and viral replication capacity. Götte M 2007 Antiviral Res
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Götte M 2007 Antimicrob Agents Chemother
Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Götte M 2007 Current opinion in HIV and AIDS
Should we include connection domain mutations of HIV-1 reverse transcriptase in HIV resistance testing. Götte M 2007 PLoS medicine
Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation. Götte M 2006 Curr Pharm Des
Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. Götte M 2006 J Virol
Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. Götte M 2006 J Virol
Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase. Götte M 2005 Antimicrob Agents Chemother
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations. Götte M 2005 Antimicrob Agents Chemother
Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance. Götte M 2004 Expert Rev Anti Infect Ther
Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases. Götte M 2004 Journal of molecular biology
Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides. Götte M 2004 Int J Biochem Cell Biol
Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC. Götte M 2003 The Journal of biological chemistry
Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase. Götte M 2003 Antimicrobial agents and chemotherapy
Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity. Götte M 2003 Journal of virology
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance. Götte M 2003 The Journal of biological chemistry
Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis. Götte M 2003 Virology
The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates. Götte M 2003 Antimicrobial agents and chemotherapy
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1. Götte M 2002 Antimicrobial agents and chemotherapy
Nonradioactive detection of retroviral-associated RNase H activity in a microplate-based, high-throughput format. Götte M 2002 BioTechniques
The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses. Götte M 2002 AIDS (London, England)
Analysis of efficiency and fidelity of HIV-1 (+)-strand DNA synthesis reveals a novel rate-limiting step during retroviral reverse transcription. Götte M 2001 The Journal of biological chemistry
Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication. Götte M 2001 Journal of virology
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. Götte M 2000 J Virol
Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers. Götte M 2000 Nucleic acids research
Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase. Götte M 2000 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal. Götte M 1999 The Journal of biological chemistry
NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription. Götte M 1999 Journal of biomolecular NMR
HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction. Götte M 1999 Archives of biochemistry and biophysics
Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals. Götte M 1998 The Journal of biological chemistry
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcription. Götte M 1998 The Journal of biological chemistry
Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing. Götte M 1998 The Journal of biological chemistry
Probing the higher order structure of RNA with peroxonitrous acid. Götte M 1996 FEBS letters
HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. Götte M 1995 The EMBO journal
The 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases. Götte M 1994 Nucleic acids research

Version:20240425

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.