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Parniak MA

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Publications:

Title Authors Year Journal
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Parniak MA 2013 Retrovirology
The hepatitis B virus ribonuclease h is sensitive to inhibitors of the human immunodeficiency virus ribonuclease h and integrase enzymes. Parniak MA 2013 PLoS pathogens
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus. Parniak MA 2013 Journal of medicinal chemistry
Effects of 4' - and 2-Substitutions on the Bioactivity of 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine. Parniak MA 2013 Antimicrobial agents and chemotherapy
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine. Parniak MA 2012 The Journal of biological chemistry
Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain. Parniak MA 2012 Chemical biology & drug design
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase. Parniak MA 2012 Antimicrobial agents and chemotherapy
Effect of translocation defective reverse transcriptase inhibitors on the activity of n348i, a connection subdomain drug resistant hiv-1 reverse transcriptase mutant. Parniak MA 2012 Cellular and molecular biology (Noisy-le-Grand, France)
Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity. Parniak MA 2012 Biology
Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor. Parniak MA 2011 Chemical biology & drug design
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Parniak MA 2011 Nucleic acids research
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Parniak MA 2011 Cellular and molecular biology (Noisy-le-Grand, France)
Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Parniak MA 2011 Journal of chemical information and modeling
The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site. Parniak MA 2010 Retrovirology
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Parniak MA 2009 Journal of molecular biology
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Parniak MA 2008 Bioorganic & medicinal chemistry
Inhibitors of HIV-1 reverse transcriptase. Parniak MA 2008 Advances in pharmacology (San Diego, Calif.)
Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. Parniak MA 2008 PloS one
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Parniak MA 2007 Journal of molecular biology
Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT. Parniak MA 2007 Organic letters
3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Parniak MA 2007 Biochemistry
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Parniak MA 2006 ACS Chem Biol
Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. Parniak MA 2005 Journal of virology
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Parniak MA 2005 Nucleic acids research
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities. Parniak MA 2005 Biochemistry
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Parniak MA 2005 The Journal of biological chemistry
A capillary electrophoretic assay for ribonuclease H activity. Parniak MA 2004 Analytical biochemistry
Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Parniak MA 2004 The international journal of biochemistry & cell biology
A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Parniak MA 2003 Analytical biochemistry
Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis. Parniak MA 2003 Protein science : a publication of the Protein Society
Primer unblocking and rescue of DNA synthesis by azidothymidine (AZT)-resistant HIV-1 reverse transcriptase: comparison between initiation and elongation of reverse transcription and between (-) and (+) strand DNA synthesis. Parniak MA 2002 The Journal of biological chemistry
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. Parniak MA 2002 The Journal of biological chemistry
Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Parniak MA 2002 Antiviral research
Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana. Parniak MA 2002 Antiviral therapy
Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT. Parniak MA 2002 Antimicrobial agents and chemotherapy
Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Parniak MA 2002 Molecular pharmacology
A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors. Parniak MA 2002 Antimicrobial agents and chemotherapy
Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Parniak MA 2000 Cellular and molecular life sciences : CMLS
Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1. Parniak MA 2000 Journal of molecular biology
Mutational analysis of Lys65 of HIV-1 reverse transcriptase. Parniak MA 2000 Biochem J
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. Parniak MA 2000 The Journal of biological chemistry
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. Parniak MA 2000 J Virol
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine. Parniak MA 2000 Biochemistry
Inhibitors of HIV-1 reverse transcriptase. Parniak MA 2000 Advances in pharmacology (San Diego, Calif.)
Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase. Parniak MA 1999 Antiviral therapy
HIV resistance to zidovudine: the role of pyrophosphorolysis. Parniak MA 1999 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1. Parniak MA 1999 Antimicrobial agents and chemotherapy
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. Parniak MA 1998 The Journal of general virology
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Parniak MA 1998 Biochemistry
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates. Parniak MA 1998 Journal of molecular biology
Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes. Parniak MA 1998 Biochemistry
Effects of mutations in Pr160gag-pol upon tRNA(Lys3) and Pr160gag-plo incorporation into HIV-1. Parniak MA 1997 Journal of molecular biology
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Parniak MA 1997 Biochemistry
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. Parniak MA 1997 J Virol
Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. Parniak MA 1997 Int J Biochem Cell Biol
The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Parniak MA 1997 Biochemistry
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. Parniak MA 1997 Journal of virology
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Parniak MA 1996 Journal of virology
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site. Parniak MA 1996 Journal of virology
HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3). Parniak MA 1996 Biochemical and biophysical research communications
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Parniak MA 1996 AIDS (London, England)
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Parniak MA 1996 Protein expression and purification
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Parniak MA 1996 Molecular pharmacology
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Parniak MA 1996 The Journal of biological chemistry
Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme. Parniak MA 1995 Biochemistry
[Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds]. Parniak MA 1995 Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Parniak MA 1995 Proceedings of the National Academy of Sciences of the United States of America
Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Parniak MA 1995 Biochemistry
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. Parniak MA 1994 The Journal of biological chemistry
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Parniak MA 1994 Antimicrobial agents and chemotherapy
The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. Parniak MA 1994 The Journal of biological chemistry
Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene. Parniak MA 1994 Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase. Parniak MA 1993 Journal of medical virology
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Parniak MA 1993 Antimicrob Agents Chemother
In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine. Parniak MA 1992 Journal of virology
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. Parniak MA 1992 J Virol
Variable tRNA content in HIV-1IIIB. Parniak MA 1992 Biochemical and biophysical research communications
Clinical significance and characterization of AZT-resistant strains of HIV-1. Parniak MA 1991 The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
Characterization of reverse transcriptase activity and susceptibility to other nucleosides of AZT-resistant variants of HIV-1. Results from the Canadian AZT Multicentre Study. Parniak MA 1990 Annals of the New York Academy of Sciences

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