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Parniak MA

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Publications:

Title Authors Year Journal
The hepatitis B virus ribonuclease h is sensitive to inhibitors of the human immunodeficiency virus ribonuclease h and integrase enzymes. Parniak MA 2013 PLoS pathogens
Effects of 4' - and 2-Substitutions on the Bioactivity of 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine. Parniak MA 2013 Antimicrobial agents and chemotherapy
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus. Parniak MA 2013 Journal of medicinal chemistry
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Parniak MA 2013 Retrovirology
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase. Parniak MA 2012 Antimicrobial agents and chemotherapy
Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain. Parniak MA 2012 Chemical biology & drug design
Effect of translocation defective reverse transcriptase inhibitors on the activity of n348i, a connection subdomain drug resistant hiv-1 reverse transcriptase mutant. Parniak MA 2012 Cellular and molecular biology (Noisy-le-Grand, France)
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine. Parniak MA 2012 The Journal of biological chemistry
Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity. Parniak MA 2012 Biology
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Parniak MA 2011 Cellular and molecular biology (Noisy-le-Grand, France)
Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor. Parniak MA 2011 Chemical biology & drug design
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Parniak MA 2011 Nucleic acids research
Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Parniak MA 2011 Journal of chemical information and modeling
The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site. Parniak MA 2010 Retrovirology
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Parniak MA 2009 Journal of molecular biology
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Parniak MA 2008 Bioorganic & medicinal chemistry
Inhibitors of HIV-1 reverse transcriptase. Parniak MA 2008 Advances in pharmacology (San Diego, Calif.)
Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. Parniak MA 2008 PloS one
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Parniak MA 2007 Journal of molecular biology
Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT. Parniak MA 2007 Organic letters
3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Parniak MA 2007 Biochemistry
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Parniak MA 2006 ACS Chem Biol
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Parniak MA 2005 Nucleic acids research
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities. Parniak MA 2005 Biochemistry
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Parniak MA 2005 The Journal of biological chemistry
Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. Parniak MA 2005 Journal of virology
A capillary electrophoretic assay for ribonuclease H activity. Parniak MA 2004 Analytical biochemistry
Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Parniak MA 2004 The international journal of biochemistry & cell biology
A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Parniak MA 2003 Analytical biochemistry
Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis. Parniak MA 2003 Protein science : a publication of the Protein Society
Primer unblocking and rescue of DNA synthesis by azidothymidine (AZT)-resistant HIV-1 reverse transcriptase: comparison between initiation and elongation of reverse transcription and between (-) and (+) strand DNA synthesis. Parniak MA 2002 The Journal of biological chemistry
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. Parniak MA 2002 The Journal of biological chemistry
Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Parniak MA 2002 Antiviral research
Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana. Parniak MA 2002 Antiviral therapy
Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT. Parniak MA 2002 Antimicrobial agents and chemotherapy
Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Parniak MA 2002 Molecular pharmacology
A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors. Parniak MA 2002 Antimicrobial agents and chemotherapy
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine. Parniak MA 2000 Biochemistry
Mutational analysis of Lys65 of HIV-1 reverse transcriptase. Parniak MA 2000 Biochem J
Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Parniak MA 2000 Cellular and molecular life sciences : CMLS
Inhibitors of HIV-1 reverse transcriptase. Parniak MA 2000 Advances in pharmacology (San Diego, Calif.)
Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1. Parniak MA 2000 Journal of molecular biology
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. Parniak MA 2000 The Journal of biological chemistry
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. Parniak MA 2000 J Virol
Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase. Parniak MA 1999 Antiviral therapy
HIV resistance to zidovudine: the role of pyrophosphorolysis. Parniak MA 1999 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1. Parniak MA 1999 Antimicrobial agents and chemotherapy
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. Parniak MA 1998 The Journal of general virology
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates. Parniak MA 1998 Journal of molecular biology
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Parniak MA 1998 Biochemistry
Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes. Parniak MA 1998 Biochemistry
Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. Parniak MA 1997 Int J Biochem Cell Biol
The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Parniak MA 1997 Biochemistry
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Parniak MA 1997 Biochemistry
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. Parniak MA 1997 J Virol
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. Parniak MA 1997 Journal of virology
Effects of mutations in Pr160gag-pol upon tRNA(Lys3) and Pr160gag-plo incorporation into HIV-1. Parniak MA 1997 Journal of molecular biology
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Parniak MA 1996 AIDS (London, England)
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site. Parniak MA 1996 Journal of virology
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Parniak MA 1996 Journal of virology
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Parniak MA 1996 Protein expression and purification
HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3). Parniak MA 1996 Biochemical and biophysical research communications
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Parniak MA 1996 The Journal of biological chemistry
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Parniak MA 1996 Molecular pharmacology
[Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds]. Parniak MA 1995 Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme. Parniak MA 1995 Biochemistry
Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Parniak MA 1995 Proceedings of the National Academy of Sciences of the United States of America
Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Parniak MA 1995 Biochemistry
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. Parniak MA 1994 The Journal of biological chemistry
The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. Parniak MA 1994 The Journal of biological chemistry
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Parniak MA 1994 Antimicrobial agents and chemotherapy
Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene. Parniak MA 1994 Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase. Parniak MA 1993 Journal of medical virology
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Parniak MA 1993 Antimicrob Agents Chemother
In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine. Parniak MA 1992 Journal of virology
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. Parniak MA 1992 J Virol
Variable tRNA content in HIV-1IIIB. Parniak MA 1992 Biochemical and biophysical research communications
Clinical significance and characterization of AZT-resistant strains of HIV-1. Parniak MA 1991 The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses
Characterization of reverse transcriptase activity and susceptibility to other nucleosides of AZT-resistant variants of HIV-1. Results from the Canadian AZT Multicentre Study. Parniak MA 1990 Annals of the New York Academy of Sciences
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