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Kuchta RD

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Publications:

Title Authors Year Journal
Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Kuchta RD 2009 Biochemistry
Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. Kuchta RD 2009 Biochemistry
Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. Kuchta RD 2009 Biochemistry
Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Kuchta RD 2009 Biochemistry
Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha. Kuchta RD 2009 Biochemistry
Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. Kuchta RD 2009 The Journal of biological chemistry
Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Kuchta RD 2007 Biochemistry
A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues. Kuchta RD 2006 Nucleic acids research
Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. Kuchta RD 2005 Nucleic acids research
Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase. Kuchta RD 2004 Biochem Pharmacol
Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Kuchta RD 2003 Biochemistry
Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase. Kuchta RD 2000 Biochem Pharmacol
Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase alpha during the synthesis of new DNA strands. Kuchta RD 1999 Biochemistry
Interactions of calf thymus DNA polymerase alpha with primer/templates. Kuchta RD 1995 Nucleic acids research
Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate. Kuchta RD 1995 Biochem Biophys Res Commun
Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alpha. Kuchta RD 1994 The Journal of biological chemistry
DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Kuchta RD 1993 Biochemistry
Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). Kuchta RD 1991 Biochemistry
Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. Kuchta RD 1988 Biochemistry
Kinetic mechanism of DNA polymerase I (Klenow). Kuchta RD 1987 Biochemistry

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