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Lewi PJ

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Publications:

Title Authors Year Journal
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data. Lewi PJ Journal of computer-aided molecular design
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Lewi PJ 2008 Proceedings of the National Academy of Sciences of the United States of America
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). Lewi PJ 2005 J Med Chem
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. Lewi PJ 2005 J Med Chem
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity. Lewi PJ 2005 Journal of medicinal chemistry
Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors. Lewi PJ 2005 Progress in biophysics and molecular biology
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1. Lewi PJ 2005 Journal of medicinal chemistry
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Lewi PJ 2004 Antimicrobial agents and chemotherapy
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Lewi PJ 2004 J Med Chem
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds. Lewi PJ 2004 Drugs in R&D
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Lewi PJ 2001 Bioorganic & medicinal chemistry letters
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. Lewi PJ 2001 Bioorganic & medicinal chemistry letters
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