Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.

Ludovici DW, De Corte BL, Kukla MJ, Ye H, Ho CY, Lichtenstein MA, Kavash RW, Andries K, De Béthune MP, Azijn H, Pauwels R, Lewi PJ, Heeres J, Koymans LM, De Jonge MR, Van Aken KJ, Daeyaert FF, Das K, Arnold E, Janssen PA
Bioorganic & medicinal chemistry letters (2001), Volume 11, Page 2235
PubMed entry

Abstract:

The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines ...
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.

Polymerases:

HIV RT

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