Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

Ludovici DW, Kavash RW, Kukla MJ, Ho CY, Ye H, De Corte BL, Andries K, De Béthune MP, Azijn H, Pauwels R, Moereels HE, Heeres J, Koymans LM, De Jonge MR, Van Aken KJ, Daeyaert FF, Lewi PJ, Das K, Arnold E, Janssen PA
Bioorganic & medicinal chemistry letters (2001), Volume 11, Page 2229
PubMed entry

Abstract:

A synthesis program directed toward improving the stability of imidoyl ...
A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.

Polymerases:

HIV RT

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