Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

Heeres J, De Jonge MR, Koymans LM, Daeyaert FF, Vinkers MH, Van Aken KJ, Arnold E, Das K, Kilonda A, Hoornaert GJ, Compernolle F, Cegla M, Azzam RA, Andries K, De Béthune MP, Azijn H, Pauwels R, Lewi PJ, Janssen PA
Journal of medicinal chemistry (2005), Volume 48, Page 1910
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Abstract:

A series of novel pyrazinones designed as non-nucleoside reverse ...
A series of novel pyrazinones designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs) was synthesized and their anti-HIV structure-activity relationship (SAR) was studied.

Polymerases:

HIV RT

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