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De Béthune MP

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Publications:

Title Authors Year Journal
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data. De Béthune MP Journal of computer-aided molecular design
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. De Béthune MP 2008 Antimicrobial agents and chemotherapy
Short-term antiviral activity of TMC278--a novel NNRTI--in treatment-naive HIV-1-infected subjects. De Béthune MP 2006 AIDS
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity. De Béthune MP 2005 Journal of medicinal chemistry
TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments. De Béthune MP 2005 Journal of virology
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1. De Béthune MP 2005 Journal of medicinal chemistry
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains. De Béthune MP 2005 Journal of medicinal chemistry
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). De Béthune MP 2005 J Med Chem
TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. De Béthune MP 2004 Antimicrob Agents Chemother
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds. De Béthune MP 2004 Drugs in R&D
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. De Béthune MP 2004 J Med Chem
Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU). De Béthune MP 2001 Bioorganic & medicinal chemistry letters
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. De Béthune MP 2001 Bioorganic & medicinal chemistry letters
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. De Béthune MP 2001 Bioorganic & medicinal chemistry letters

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