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Polymerase: Human Pol beta

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Polymerase Reference Property Result Context
Human Pol beta Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Nick Extension Yes, via strand displacement
Human Pol beta Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Molecular Weight 39kD
Human Pol beta Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. 3-5' Exonuclease (proofreading) No
Human Pol beta Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. 5-3' Exonuclease No
Human Pol beta Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Full length or truncated Full length
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Molecular Weight 3.9E+04 Dalton Technique: SDS-PAGE
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. 3-5' Exonuclease (proofreading) No
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Cloned or native Cloned in E. coli
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. 5-3' Exonuclease No
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Full length or truncated Full length
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Processivity 8bp
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Nick Extension No
Human Pol beta Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Gap Filling No
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Incorporation of non-standard nucleotides 95% + Nucleotide analog: 2',3'-Dideoxyribonucleotide nucleoside triphosphate
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Cloned or native Native organism
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Tagged Unspecified
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Full length or truncated Unspecified
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. KM 2.6uM Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. KM 1.7uM Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. KM 1.2uM Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. KM 2.3uM Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Activated DNA)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. KM 1.5uM Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Activated DNA)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Vmax 1.5 /second Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Vmax 27 /second Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Vmax 18 /second Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Application name PCR
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Kd 810uM Reaction: Nucleotide incorporation; Substrate: TTP analog; Technique: Steady State (Activated DNA)
Human Pol beta Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. Kd 2uM Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Activated DNA)
Human Pol beta Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways. Kd 6.8uM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State (T template)
Human Pol beta Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways. Kd 489uM Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State (T template)
Human Pol beta Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways. Kd 2.2uM Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State (C template)
Human Pol beta Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways. Kd 227uM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State (C template)
Human Pol beta Short gap-filling synthesis by DNA polymerase beta is processive. Full length or truncated Full length
Human Pol beta Short gap-filling synthesis by DNA polymerase beta is processive. Processivity 6bp
Human Pol beta Short gap-filling synthesis by DNA polymerase beta is processive. Gap Filling Yes
Human Pol beta On the processive mechanism of Escherichia coli DNA polymerase I. Quantitative assessment of processivity. Full length or truncated Full length
Human Pol beta On the processive mechanism of Escherichia coli DNA polymerase I. Quantitative assessment of processivity. Processivity 1bp
Human Pol beta Thermostable DNA polymerases. Molecular Weight 1.25E+05 Dalton
Human Pol beta Thermostable DNA polymerases. 3-5' Exonuclease (proofreading) No
Human Pol beta Thermostable DNA polymerases. 5-3' Exonuclease No
Human Pol beta Thermostable DNA polymerases. Full length or truncated Full length
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 9uM Reaction: Misincorporation; Substrate: dCTP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 590uM Reaction: Misincorporation; Substrate: dTTP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 72uM Reaction: Misincorporation; Substrate: dATP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 120uM Reaction: Misincorporation; Substrate: dGTP; Technique: Single Turnover (G template)
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Molecular Weight 39kD
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. 3-5' Exonuclease (proofreading) No
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. 5-3' Exonuclease No
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dCTP; DNA lesion: 8-oxo-dG
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Amino Acids Contacting Primer Tyr271
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Overall Error Rate 0.0005 errors/bp
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Overall Error Rate 0.0024 errors/bp
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Full length or truncated Full length
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Amino Acids Contacting Template Arg283 and Tyr271
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Other Important Residues Tyr271, Phe272, Asp276, and Asn279 = dNTP binding pocket; Tyr271 = important for both chemistry and dNTP binding, alters steady-state catalytic efficiency
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Amino Acids Contacting NTP Phe272, Asp276 and Asn279
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Strand Displacement Yes
Human Pol beta DNA polymerase family X: function, structure, and cellular roles. Associated condition I260M and K289M - Cancer
Human Pol beta The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. Overall Error Rate 0.076 errors/bp Technique: M13mp2 forward mutation assay
Human Pol beta The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. Gap Filling Yes
Human Pol beta Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. Nucleotide Substitution Rate 0.00067 errors/bp
Human Pol beta Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Template lesions Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: OPdA

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.