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Polymerase: Human Pol beta

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This page presents all the results for a polymerase, property or reference. To find more information about a polymerase or reference, follow the relevant link.

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Polymerase Reference Property Result Context
Human Pol beta Sawaya MR1997 Molecular Weight 39kD
Human Pol beta Sawaya MR1997 3-5' Exonuclease (proofreading) No
Human Pol beta Sawaya MR1997 5-3' Exonuclease No
Human Pol beta Sawaya MR1997 Full length or truncated Full length
Human Pol beta Sawaya MR1997 Nick Extension Yes, via strand displacement
Human Pol beta Copeland WC1992 Incorporation of non-standard nucleotides 95% + Nucleotide analog: 2',3'-Dideoxyribonucleotide nucleoside triphosphate
Human Pol beta Copeland WC1992 Cloned or native Native organism
Human Pol beta Copeland WC1992 Tagged Unspecified
Human Pol beta Copeland WC1992 Full length or truncated Unspecified
Human Pol beta Copeland WC1992 KM 2.6uM Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 KM 1.7uM Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 KM 1.2uM Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 KM 2.3uM Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Activated DNA)
Human Pol beta Copeland WC1992 KM 1.5uM Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Activated DNA)
Human Pol beta Copeland WC1992 Vmax 1.5 /second Reaction: Nucleotide incorporation; Substrate: dTTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 Vmax 27 /second Reaction: Nucleotide incorporation; Substrate: dCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 Vmax 18 /second Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Standing start primer template)
Human Pol beta Copeland WC1992 Application name PCR
Human Pol beta Copeland WC1992 Kd 810uM Reaction: Nucleotide incorporation; Substrate: TTP analog; Technique: Steady State (Activated DNA)
Human Pol beta Copeland WC1992 Kd 2uM Reaction: Nucleotide incorporation; Substrate: ddCTP; Technique: Steady State (Activated DNA)
Human Pol beta Abbotts J1988 Molecular Weight 3.9E+04 Dalton Technique: SDS-PAGE
Human Pol beta Abbotts J1988 3-5' Exonuclease (proofreading) No
Human Pol beta Abbotts J1988 Cloned or native Cloned in E. coli
Human Pol beta Abbotts J1988 5-3' Exonuclease No
Human Pol beta Abbotts J1988 Full length or truncated Full length
Human Pol beta Abbotts J1988 Processivity 8bp
Human Pol beta Abbotts J1988 Nick Extension No
Human Pol beta Abbotts J1988 Gap Filling No
Human Pol beta Singhal RK1993 Full length or truncated Full length
Human Pol beta Singhal RK1993 Processivity 6bp
Human Pol beta Singhal RK1993 Gap Filling Yes
Human Pol beta Bambara RA1978 Full length or truncated Full length
Human Pol beta Bambara RA1978 Processivity 1bp
Human Pol beta Perler FB1996 Molecular Weight 1.25E+05 Dalton
Human Pol beta Perler FB1996 3-5' Exonuclease (proofreading) No
Human Pol beta Perler FB1996 5-3' Exonuclease No
Human Pol beta Perler FB1996 Full length or truncated Full length
Human Pol beta Roettger MP2008 Kd 6.8uM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State (T template)
Human Pol beta Roettger MP2008 Kd 489uM Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State (T template)
Human Pol beta Roettger MP2008 Kd 2.2uM Reaction: Nucleotide incorporation; Substrate: dGTP; Technique: Steady State (C template)
Human Pol beta Roettger MP2008 Kd 227uM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Steady State (C template)
Human Pol beta Yamtich J2010 Kd 9uM Reaction: Misincorporation; Substrate: dCTP; Technique: Single Turnover (G template)
Human Pol beta Yamtich J2010 Kd 590uM Reaction: Misincorporation; Substrate: dTTP; Technique: Single Turnover (G template)
Human Pol beta Yamtich J2010 Kd 72uM Reaction: Misincorporation; Substrate: dATP; Technique: Single Turnover (G template)
Human Pol beta Yamtich J2010 Kd 120uM Reaction: Misincorporation; Substrate: dGTP; Technique: Single Turnover (G template)
Human Pol beta Yamtich J2010 Molecular Weight 39kD
Human Pol beta Yamtich J2010 3-5' Exonuclease (proofreading) No
Human Pol beta Yamtich J2010 5-3' Exonuclease No
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dCTP; DNA lesion: 8-oxo-dG
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta Yamtich J2010 Amino Acids Contacting Primer Tyr271
Human Pol beta Yamtich J2010 Overall Error Rate 0.0005 errors/bp
Human Pol beta Yamtich J2010 Overall Error Rate 0.0024 errors/bp
Human Pol beta Yamtich J2010 Full length or truncated Full length
Human Pol beta Yamtich J2010 Amino Acids Contacting Template Arg283 and Tyr271
Human Pol beta Yamtich J2010 Other Important Residues Tyr271, Phe272, Asp276, and Asn279 = dNTP binding pocket; Tyr271 = important for both chemistry and dNTP binding, alters steady-state catalytic efficiency
Human Pol beta Yamtich J2010 Amino Acids Contacting NTP Phe272, Asp276 and Asn279
Human Pol beta Yamtich J2010 Strand Displacement Yes
Human Pol beta Yamtich J2010 Associated condition I260M and K289M - Cancer
Human Pol beta Kunkel TA1985 Overall Error Rate 0.076 errors/bp Technique: M13mp2 forward mutation assay
Human Pol beta Kunkel TA1985 Gap Filling Yes
Human Pol beta Ohashi E2000 Nucleotide Substitution Rate 0.00067 errors/bp
Human Pol beta Maddukuri L2013 Template lesions Stalls Reaction: Nucleotide incorporation; Substrate: n/a; DNA lesion: OPdA

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.