Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

Sarafianos SG, Das K, Ding J, Boyer PL, Hughes SH, Arnold E
Chemistry & biology (1999), Volume 6, Page R137
PubMed entry

Abstract:

Comparison of the recently solved structure of HIV-1 reverse ...
Comparison of the recently solved structure of HIV-1 reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.

Polymerases:

HIV RT

Topics:

Health/Disease

Status:

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