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Boyer PL

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Publications:

Title Authors Year Journal
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data. Boyer PL Journal of computer-aided molecular design
Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease. Boyer PL 2013 Virology
HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors. Boyer PL 2012 Journal of virology
Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation. Boyer PL 2011 Journal of virology
Structural basis of HIV-1 resistance to AZT by excision. Boyer PL 2010 Nature structural & molecular biology
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Boyer PL 2009 The Journal of biological chemistry
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription. Boyer PL 2009 Journal of medicinal chemistry
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Boyer PL 2008 Nucleic acids research
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect. Boyer PL 2008 The Journal of biological chemistry
HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Boyer PL 2008 Proceedings of the National Academy of Sciences of the United States of America
In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT. Boyer PL 2007 Virology
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. Boyer PL 2007 Journal of molecular biology
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants. Boyer PL 2007 Journal of molecular biology
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine. Boyer PL 2006 Journal of virology
Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance? Boyer PL 2006 PLoS Pathog
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Boyer PL 2004 J Med Chem
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Boyer PL 2004 Nature structural & molecular biology
Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase. Boyer PL 2004 Journal of virology
Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis. Boyer PL 2004 Virology
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Boyer PL 2004 Nucleic acids research
Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. Boyer PL 2004 J Virol
A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides. Boyer PL 2004 J Med Chem
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude. Boyer PL 2003 Journal of medicinal chemistry
A novel mechanism for inhibition of HIV-1 reverse transcriptase. Boyer PL 2002 Bioorganic chemistry
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. Boyer PL 2002 The EMBO journal
The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1. Boyer PL 2002 J Virol
Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity. Boyer PL 2002 Journal of virology
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision. Boyer PL 2002 J Virol
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase. Boyer PL 2001 Journal of virology
Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer. Boyer PL 2001 Journal of virology
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. Boyer PL 2001 Journal of molecular biology
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. Boyer PL 2001 J Virol
YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro. Boyer PL 2001 J Virol
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. Boyer PL 2001 The EMBO journal
The basic loop of the RNase H domain of MLV RT is important both for RNase H and for polymerase activity. Boyer PL 2001 Virology
Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase. Boyer PL 2000 Proceedings of the National Academy of Sciences of the United States of America
Effects of amino acid substitutions at position 115 on the fidelity of human immunodeficiency virus type 1 reverse transcriptase. Boyer PL 2000 Journal of virology
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. Boyer PL 2000 Journal of molecular biology
Analysis of amino insertion mutations in the fingers subdomain of HIV-1 reverse transcriptase. Boyer PL 1999 Journal of molecular biology
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Boyer PL 1999 Proceedings of the National Academy of Sciences of the United States of America
Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site. Boyer PL 1999 Chemistry & biology
Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase. Boyer PL 1998 Proceedings of the National Academy of Sciences of the United States of America
Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase. Boyer PL 1998 Journal of molecular biology
A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer. Boyer PL 1998 Antimicrobial agents and chemotherapy
Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action. Boyer PL 1997 Protein engineering
Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity. Boyer PL 1997 Journal of virology
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. Boyer PL 1997 Journal of medicinal chemistry
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. Boyer PL 1996 Journal of molecular biology
Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies. Boyer PL 1996 Drug design and discovery
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Boyer PL 1995 Virology
Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors: total energy of complexation as a predictor of drug placement and activity. Boyer PL 1995 Protein science : a publication of the Protein Society
Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1. Boyer PL 1995 Antimicrobial agents and chemotherapy
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. Boyer PL 1994 Journal of molecular biology
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Boyer PL 1994 Antimicrobial agents and chemotherapy
Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase. Boyer PL 1994 Journal of molecular biology
Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors. Boyer PL 1994 AIDS research and human retroviruses
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Boyer PL 1994 Proceedings of the National Academy of Sciences of the United States of America
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. Boyer PL 1993 Journal of virology
Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1. Boyer PL 1992 Journal of virology
Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase. Boyer PL 1992 Journal of virology
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