Human Pol beta
From
H. sapiens
(aliases:beta-pol, hPol beta)
(genes: POLB)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol beta.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol beta
is a family X enzyme
from
H. sapiens.
Pol beta is important for lesion bypass
Selected Properties for Human Pol beta: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (4) | No (4) | no data | 6.7e-04 errors/bp (1) | 5.0e-04-7.6e-02 errors/bp (3) |
| Year | Authors | Title | Results by property |
|---|---|---|---|
| X.-P. Yang, Feng He, Teresa Y Rawson, Samuel H Wilson | Human DNA Polymerase-beta Promoter: P... | ||
| 2018 | J Huang, KS Alnajjar, MM Mahmoud, BE Eckenroth, S Doublie, J Sweasy | The nature of the DNA substrate influ... | |
| 2013 | Adam J Stevens, Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | DNA Polymerase λ Inactivation by Oxid... | |
| 2013 | Aya Masaoka, Natalie R Gassman, Julie K Horton, Padmini S Kedar, Kristine L Witt, Cheryl A Hobbs, Grace E Kissling, Keizo Tano, Kenjiro Asagoshi, Samuel H Wilson | Interaction between DNA Polymerase β ... | |
| 2013 | Brian E Eckenroth, Jamie B Towle-Weicksel, Joann B Sweasy, Sylvie Doubli Eacute | The E295K cancer variant of human pol... | |
| 2013 | Changlong An, William A Beard, D Chen, Samuel H Wilson, NM Makridakis | Understanding the loss-of-function in... | |
| 2013 | Tobias Strittmatter, Anette Brockmann, Moritz Pott, Annika Hantusch, Thomas Brunner, Andreas Marx | Expanding the Scope of Human DNA Poly... | |
| 2013 | Vinod K Batra, Lalith Perera, Ping Lin, David D Shock, William A Beard, Lars C Pedersen, Lee G Pedersen, Samuel H Wilson | Amino acid substitution in the active... | |
| 2013 | Wei Zhao, Mei Wu, Yanhao Lai, Wenwen Deng, Yuan Liu, Zhenzhong Zhang | Involvement of DNA polymerase β overe... | |
| 2013 | Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett | Replication, Repair and Translesion P... | Template lesions,All properties |
| 2013 | Natalia A Lebedeva, Nadejda I Rechkunova, Alexander A Ishchenko, Murat Saparbaev, Olga I Lavrik | The mechanism of human tyrosyl-DNA ph... | |
| 2012 | Yingqian Li, Chelsea L Gridley, Joachim Jaeger, Joann B Sweasy, Tamar Schlick | Unfavorable electrostatic and steric ... | |
| 2012 | Katherine A Donigan, Ka-Wai Sun, Antonia A Nemec, Drew L Murphy, Xiangyu Cong, Veronika Northrup, Daniel Zelterman, Joann B Sweasy | The Human POLB Gene is Mutated in a H... | |
| 2012 | |||
| 2012 | Yuan Liu, Samuel H Wilson | DNA base excision repair: a mechanism... | |
| 2012 | Katherine A Donigan, Suzanne E Hile, Kristin A Eckert, Joann B Sweasy | The human gastric cancer-associated D... | |
| 2012 | Yue Wu, Valeria M Zakharova, Boris A Kashemirov, Myron F Goodman, Vinod K Batra, Samuel H Wilson, Charles E McKenna | β,γ-CHF- and β,γ-CHCl-dGTP diastereom... | |
| 2012 | KH Barakat, MM Gajewski, JA Tuszynski | DNA polymerase beta (pol β) inhibitor... | |
| 2012 | Marco Calafiore, Agata Copani, Wenbin Deng | DNA polymerase-β mediates the neuroge... | |
| 2012 | Yue Wu, Valeria M Zakharova, Boris A Kashemirov, Myron F Goodman, Vinod K Batra, Samuel H Wilson, Charles E McKenna | β,γ-CHF- and β,γ-CHCl-dGTP diastereom... | |
| 2012 | Drew L Murphy, Katherine A Donigan, Joachim Jaeger, Joann B Sweasy | The E288K Colon Tumor Variant of DNA ... | |
| 2011 | Drew L Murphy, Joachim Jaeger, Joann B Sweasy | A triad interaction in the fingers su... | |
| 2011 | Jason L Parsons, Irina I Dianova, Svetlana V Khoronenkova, Mariola J Edelmann, Benedikt M Kessler, Grigory L Dianov | USP47 is a deubiquitylating enzyme th... | |
| 2011 | Aaron C Jacobs, Cortney R Kreller, Marc M Greenberg | Long patch base excision repair compe... | |
| 2011 | Chen Chen, Mo Yang, Zun-zhen Zhang, Mei Wu, Wen-wen Deng | [Effect of DNA polymerase beta on apo... | |
| 2011 | Ian D Odell, Joy-El Barbour, Drew L Murphy, Julie A Della Maria, Joann B Sweasy, Alan E Tomkinson, Susan S Wallace, David S Pederson | Nucleosome Disruption by DNA Ligase I... | |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2011 | Jiang-bo Tang, David Svilar, Ram N Trivedi, Xiao-Hong Wang, Eva M Goellner, Briana Moore, Ronald L Hamilton, Lauren A Banze, Ashley R Brown, Robert W Sobol | N-methylpurine DNA glycosylase and DN... | |
| 2011 | Anbarasi Kothandapani, Venkata Srinivas Mohan Nimai Dangeti, Ashley R Brown, Lauren A Banze, Xiao-Hong Wang, Robert W Sobol, Steve M Patrick | Novel role of base excision repair (B... | |
| 2011 | Sonja Gieseking, Konrad Bergen, Francesca Di Pasquale, Kay Diederichs, Wolfram Welte, Andreas Marx | Human DNA polymerase beta mutations a... | |
| 2011 | Khaled H Barakat, Jack A Tuszynski | Relaxed complex scheme suggests novel... | |
| 2010 | G K Surya Prakash, Mikhail Zibinsky, Thomas G Upton, Boris A Kashemirov, Charles E McKenna, Keriann Oertell, Myron F Goodman, Vinod K Batra, Lars C Pedersen, William A Beard, David D Shock, Samuel H Wilson, George A Olah | Synthesis and biological evaluation o... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Jennifer Yamtich, Joann B Sweasy | DNA polymerase family X: function, st... | Full length or truncated,Strand Displacement,3-5' exo,5-3' exo,Molecular Weight,Amino Acids Contacting Template,Amino Acids Contacting NTP,Other Important Residues,Associated condition,Template lesions,Amino Acids Contacting Primer,Overall Error Rate,All properties |
| 2010 | Kenjiro Asagoshi, Yuan Liu, Aya Masaoka, Li Lan, Rajendra Prasad, Julie K Horton, Ashley R Brown, Xiao-Hong Wang, Hussam Moh'd Bdour, Robert W Sobol, John-Stephen Taylor, Akira Yasui, Samuel H Wilson | DNA polymerase beta-dependent long pa... | |
| 2010 | Jen Yamtich, Daniela Starcevic, Julia M Lauper, Elenoe Smith, Idina Shi, Sneha Rangarajan, Joachim Jaeger, Joann B Sweasy | Hinge residue I174 is critical for pr... | Kd,All properties |
| 2010 | Robert Rucker, Peter Oelschlaeger, Arieh Warshel | A binding free energy decomposition a... | |
| 2010 | Samuel H Wilson, William A Beard, David D Shock, Vinod K Batra, Nisha A Cavanaugh, Rajendra Prasad, Esther W Hou, Yuan Liu, Kenjiro Asagoshi, Julie K Horton, Donna F Stefanick, Padmini S Kedar, Michael J Carrozza, Aya Masaoka, Michelle L Heacock | Base excision repair and design of sm... | |
| 2010 | Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | Inhibition of short patch and long pa... | |
| 2010 | Katarzyna Bebenek, Miguel Garcia-Diaz, Rui-Zhe Zhou, Lawrence F Povirk, Thomas A Kunkel | Loop 1 modulates the fidelity of DNA ... | |
| 2010 | Vinod K Batra, Lars C Pedersen, William A Beard, Samuel H Wilson, Boris A Kashemirov, Thomas G Upton, Myron F Goodman, Charles E McKenna | Halogenated beta,gamma-methylene- and... | |
| 2009 | Thomas G Upton, Boris A Kashemirov, Charles E McKenna, Myron F Goodman, G K Surya Prakash, Roman Kultyshev, Vinod K Batra, David D Shock, Lars C Pedersen, William A Beard, Samuel H Wilson | Alpha,beta-difluoromethylene deoxynuc... | |
| 2009 | Mei Wu, Zhenzhong Zhang | [Research progress on DNA polymerase ... | |
| 2009 | Zhigang Guo, Li Zheng, Huifang Dai, Mian Zhou, Hong Xu, Binghui Shen | Human DNA polymerase beta polymorphis... | |
| 2009 | William A Beard, David D Shock, Vinod K Batra, Lars C Pedersen, Samuel H Wilson | DNA polymerase beta substrate specifi... | |
| 2009 | Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov | A real-time fluorescence method for e... | |
| 2009 | Abbie M Frederick, Marguerite L Davis, Kevin P Rice | Inhibition of human DNA polymerase be... | |
| 2008 | Vinod K Batra, William A Beard, David D Shock, Lars C Pedersen, Samuel H Wilson | Structures of DNA polymerase beta wit... | |
| 2008 | Lionel Gellon, Dena R Carson, Jonathan P Carson, Bruce Demple | Intrinsic 5'-deoxyribose-5-phosphate ... | |
| 2008 | Giovanni Maga, Emmanuele Crespan, Ursula Wimmer, Barbara van Loon, Alessandra Amoroso, Chiara Mondello, Cristina Belgiovine, Elena Ferrari, Giada A Locatelli, Giuseppe Villani, Ulrich Hübscher | Replication protein A and proliferati... | |
| 2008 | Ping Lin, Vinod K Batra, Lars C Pedersen, William A Beard, Samuel H Wilson, Lee G Pedersen | Incorrect nucleotide insertion at the... | |
| 2008 | Fengting Liang, Nidhi Jain, Troy Hutchens, David D Shock, William A Beard, Samuel H Wilson, M Paul Chiarelli, Bongsup P Cho | Alpha,beta-methylene-2'-deoxynucleosi... | |
| 2008 | Michelle P Roettger, Marina Bakhtina, Ming-Daw Tsai | Mismatched and matched dNTP incorpora... | Kd,All properties |
| 2008 | Patrick P Lestienne, François Boudsocq, Jacques E Bonnet | Initiation of DNA replication by a th... | |
| 2008 | Francesca Di Pasquale, Daniela Fischer, Dina Grohmann, Tobias Restle, Armin Geyer, Andreas Marx | Opposed steric constraints in human D... | |
| 2007 | Andrea F Moon, Miguel Garcia-Diaz, Vinod K Batra, William A Beard, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson, Lars C Pedersen | The X family portrait: structural ins... | |
| 2007 | Robert W Sobol | DNA polymerase beta null mouse embryo... | |
| 2007 | Peter Oelschlaeger, Marco Klahn, William A Beard, Samuel H Wilson, Arieh Warshel | Magnesium-cationic dummy atom molecul... | |
| 2007 | Václav Martínek, Urban Bren, Myron F Goodman, Arieh Warshel, Jan Florián | DNA polymerase beta catalytic efficie... | |
| 2007 | Melanie F Brown, Jeffrey A Stuart | Correlation of mitochondrial superoxi... | |
| 2007 | Jessica A Brown, Wade W Duym, Jason D Fowler, Zucai Suo | Single-turnover kinetic analysis of t... | |
| 2007 | Christopher A Sucato, Thomas G Upton, Boris A Kashemirov, Vinod K Batra, Václav Martínek, Yun Xiang, William A Beard, Lars C Pedersen, Samuel H Wilson, Charles E McKenna, Jan Florián, Arieh Warshel, Myron F Goodman | Modifying the beta,gamma leaving-grou... | |
| 2007 | Yazhen Wang, Sujatha Reddy, William A Beard, Samuel H Wilson, Tamar Schlick | Differing conformational pathways bef... | |
| 2007 | Charles E McKenna, Boris A Kashemirov, Thomas G Upton, Vinod K Batra, Myron F Goodman, Lars C Pedersen, William A Beard, Samuel H Wilson | (R)-beta,gamma-fluoromethylene-dGTP-D... | |
| 2007 | Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya | Activity against human immunodeficien... | |
| 2006 | Vinod K Batra, David D Shock, Rajendra Prasad, William A Beard, Esther W Hou, Lars C Pedersen, Jane M Sayer, Haruhiko Yagi, Subodh Kumar, Donald M Jerina, Samuel H Wilson | Structure of DNA polymerase beta with... | |
| 2006 | Ravi Radhakrishnan, Tamar Schlick | Correct and incorrect nucleotide inco... | |
| 2006 | Ravi Radhakrishnan | Mechanism of nucleotide incorporation... | |
| 2006 | Meike Liebmann, Francesca Di Pasquale, Andreas Marx | A new photoactive building block for ... | |
| 2006 | William A Beard, Samuel H Wilson | Structure and mechanism of DNA polyme... | |
| 2006 | Ping Lin, Lars C Pedersen, Vinod K Batra, William A Beard, Samuel H Wilson, Lee G Pedersen | Energy analysis of chemistry for corr... | |
| 2006 | Vinod K Batra, William A Beard, David D Shock, Joseph M Krahn, Lars C Pedersen, Samuel H Wilson | Magnesium-induced assembly of a compl... | |
| 2005 | Toshihiro Kuroita, Hiroyoshi Matsumura, Naohiko Yokota, Masao Kitabayashi, Hiroshi Hashimoto, Tsuyoshi Inoue, Tadayuki Imanaka, Yasushi Kai | Structural mechanism for coordination... | |
| 2005 | Kimberly A Conlon, Holly Miller, Thomas A Rosenquist, Dmitry O Zharkov, Miguel Berrios | The murine DNA glycosylase NEIL2 (mNE... | |
| 2005 | Rajendra Prasad, Vinod K Batra, Xiao-Ping Yang, Joseph M Krahn, Lars C Pedersen, William A Beard, Samuel H Wilson | Structural insight into the DNA polym... | |
| 2005 | Vinod K Batra, William A Beard, David D Shock, Lars C Pedersen, Samuel H Wilson | Nucleotide-induced DNA polymerase act... | |
| 2005 | Georges Massiot, Christophe Long, Bruno David, Marie-Jeanne Serrano, Florence Daubié, Frédéric Alby, Frédéric Ausseil, Martine Knibiehler, Christian Moretti, Jean-Sébastien Hoffmann, Christophe Cazaux, Catherine Lavaud | Acylphloroglucinol derivatives from M... | |
| 2005 | Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga | Incorporation of non-nucleoside triph... | |
| 2004 | Giuseppina Blanca, Giuseppe Villani, Igor V Shevelev, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Human DNA polymerases lambda and beta... | |
| 2004 | Thomas A Kunkel | DNA replication fidelity. | |
| 2004 | Joseph M Krahn, William A Beard, Samuel H Wilson | Structural insights into DNA polymera... | |
| 2004 | William A Beard, David D Shock, Samuel H Wilson | Influence of DNA structure on DNA pol... | |
| 2004 | Linjing Yang, Karunesh Arora, William A Beard, Samuel H Wilson, Tamar Schlick | Critical role of magnesium ions in DN... | |
| 2003 | Brian C Beard, Samuel H Wilson, Michael J Smerdon | Suppressed catalytic activity of base... | |
| 2003 | Yau-Jan Chyan, Teresa Y Rawson, Samuel H Wilson | Cloning and characterization of a nov... | |
| 2003 | Stephanie A Nick McElhinny, Dale A Ramsden | Polymerase mu is a DNA-directed DNA/R... | |
| 2003 | Katarzyna Bebenek, Miguel Garcia-Diaz, Luis Blanco, Thomas A Kunkel | The frameshift infidelity of human DN... | |
| 2003 | William A Beard, Samuel H Wilson | Structural insights into the origins ... | |
| 2003 | Joseph M Krahn, William A Beard, Holly Miller, Arthur P Grollman, Samuel H Wilson | Structure of DNA polymerase beta with... | |
| 2003 | Luis G Brieba, Tom Ellenberger | Hold tight (but not too tight) to get... | |
| 2002 | Haitham T Idriss, Osama Al-Assar, Samuel H Wilson | DNA polymerase beta. | |
| 2002 | Michael J Hartenstine, Myron F Goodman, John Petruska | Weak strand displacement activity ena... | |
| 2002 | Michael S DeMott, Ergin Beyret, Donny Wong, Brian C Bales, Jae-Taeg Hwang, Marc M Greenberg, Bruce Demple | Covalent trapping of human DNA polyme... | |
| 2002 | Pui Yan Tsoi, Mengsu Yang | Kinetic study of various binding mode... | |
| 2002 | William A Beard, David D Shock, Brian J Vande Berg, Samuel H Wilson | Efficiency of correct nucleotide inse... | |
| 2002 | Linjing Yang, William A Beard, Samuel H Wilson, Suse Broyde, Tamar Schlick | Polymerase beta simulations suggest t... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Christopher A Dunlap, Ming-Daw Tsai | Use of 2-aminopurine and tryptophan f... | |
| 2001 | A J Podlutsky, Irina I Dianova, Vladimir N Podust, Vilhelm A Bohr, Grigory L Dianov | Human DNA polymerase beta initiates D... | |
| 2001 | Alexandra Vaisman, M W Warren, Stephen G Chaney | The effect of DNA structure on the ca... | |
| 2001 | Hiroshi Hashimoto, Motomu Nishioka, Shinsuke Fujiwara, Masahiro Takagi, Tadayuki Imanaka, Tsuyoshi Inoue, Yasushi Kai | Crystal structure of DNA polymerase f... | |
| 2001 | Brian J Vande Berg, William A Beard, Samuel H Wilson | DNA structure and aspartate 276 influ... | |
| 2001 | T Louat, Laurence Servant, M P Rols, Anne Bieth, J Teissie, Jean-Sébastien Hoffmann, Christophe Cazaux | Antitumor activity of 2',3'-dideoxycy... | |
| 2001 | Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter | Mechanism of action of 1-beta-D-2,6-d... | |
| 2001 | Surendran Rajendran, Maria J Jezewska, Wlodzimierz Bujalowski | Recognition of template-primer and ga... | |
| 2000 | Satya Narayan, Samuel H Wilson | Kinetic analysis of Sp1-mediated tran... | |
| 2000 | Alexandra Vaisman, Stephen G Chaney | The efficiency and fidelity of transl... | |
| 2000 | K Nagasawa, K Kitamura, Akira Yasui, Y Nimura, Kyoji Ikeda, Midori Hirai, Akio Matsukage, Makoto Nakanishi | Identification and characterization o... | |
| 2000 | Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel | Fidelity and processivity of DNA synt... | Nucleotide Substitution Rate,All properties |
| 2000 | Errol C Friedberg, William J Feaver, Valerie L Gerlach | The many faces of DNA polymerases: st... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1999 | Thomas A Steitz | DNA polymerases: structural diversity... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1999 | E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman | "Action-at-a-distance" mutagenesis. 8... | |
| 1999 | T A Winters, P S Russell, M Kohli, M E Dar, R D Neumann, T J Jorgensen | Determination of human DNA polymerase... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1998 | E K Dimitriadis, Rajendra Prasad, M K Vaske, L Chen, Alan E Tomkinson, M S Lewis, Samuel H Wilson | Thermodynamics of human DNA ligase I ... | |
| 1998 | A Tomikawa, M Seno, K Sato-Kiyotaki, C Ohtsuki, T Hirai, Tsuyoshi Yamaguchi, T Kawaguchi, Shonen Yoshida, Mineo Saneyoshi | Synthetic nucleosides and nucleotides... | |
| 1998 | Surendran Rajendran, Maria J Jezewska, Wlodzimierz Bujalowski | Human DNA polymerase beta recognizes ... | |
| 1998 | J Singh, E T Snow | Chromium(III) decreases the fidelity ... | |
| 1998 | Rajendra Prasad, William A Beard, Phyllis R Strauss, Samuel H Wilson | Human DNA polymerase beta deoxyribose... | |
| 1997 | M R Sawaya, Rajendra Prasad, Samuel H Wilson, J Kraut, H Pelletier | Crystal structures of human DNA polym... | Full length or truncated,Nick Extension,3-5' exo,5-3' exo,Molecular Weight,All properties |
| 1997 | Ashwini S Kamath-Loeb, A Hizi, Hironori Kasai, Lawrence A Loeb | Incorporation of the guanosine tripho... | |
| 1997 | E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman | Abasic translesion synthesis by DNA p... | |
| 1997 | Muhammed F Hashim, Nathalie Schnetz-Boutaud, Lawrence J Marnett | Replication of template-primers conta... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,Molecular Weight,All properties |
| 1996 | H Pelletier, M R Sawaya, W Wolfle, Samuel H Wilson, J Kraut | Crystal structures of human DNA polym... | |
| 1996 | J Singh, L Su, E T Snow | Replication across O6-methylguanine b... | |
| 1996 | Satya Narayan, Feng He, Samuel H Wilson | Activation of the human DNA polymeras... | |
| 1996 | Linda J Reha-Krantz, R L Nonay, R S Day, Samuel H Wilson | Replication of O6-methylguanine-conta... | |
| 1996 | H Pelletier, M R Sawaya, W Wolfle, Samuel H Wilson, J Kraut | Crystal structures of human DNA polym... | |
| 1996 | Yau-Jan Chyan, Phyllis R Strauss, T G Wood, Samuel H Wilson | Identification of novel mRNA isoforms... | |
| 1996 | William A Beard, Wendy P Osheroff, Rajendra Prasad, M R Sawaya, M Jaju, T G Wood, J Kraut, Thomas A Kunkel, Samuel H Wilson | Enzyme-DNA interactions required for ... | |
| 1996 | H Pelletier, M R Sawaya, W Wolfle, Samuel H Wilson, J Kraut | Crystal structures of human DNA polym... | |
| 1996 | H Pelletier, M R Sawaya, W Wolfle, Samuel H Wilson, J Kraut | A structural basis for metal ion muta... | |
| 1996 | J Matsuzaki, Y Dobashi, H Miyamoto, I Ikeda, K Fujinami, T Shuin, Y Kubota | DNA polymerase beta gene mutations in... | |
| 1996 | H Pelletier, M R Sawaya | Characterization of the metal ion bin... | |
| 1995 | Satya Narayan, William A Beard, Samuel H Wilson | DNA damage-induced transcriptional ac... | |
| 1995 | Julie K Horton, Deepak K Srivastava, B Z Zmudzka, Samuel H Wilson | Strategic down-regulation of DNA poly... | |
| 1995 | R R Vyas, A K Basu | DNA polymerase action on an oligonucl... | |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1995 | Hiroyuki Kamiya, Tadamasa Ueda, T Ohgi, Akio Matsukage, Hironori Kasai | Misincorporation of dAMP opposite 2-h... | |
| 1995 | K H Chen, T Wood, Feng He, Satya Narayan, Samuel H Wilson | The bovine DNA polymerase beta promot... | |
| 1994 | Y Dobashi, T Shuin, H Tsuruga, H Uemura, S Torigoe, Y Kubota | DNA polymerase beta gene mutation in ... | |
| 1994 | Yau-Jan Chyan, S Ackerman, N S Shepherd, O W McBride, S G Widen, Samuel H Wilson, T G Wood | The human DNA polymerase beta gene st... | |
| 1994 | K Takami, S Matsuda, A Sono, Kengo Sakaguchi | A meiotic DNA polymerase from a mushr... | |
| 1993 | Vladimir N Podust, Ulrich Hübscher | Lagging strand DNA synthesis by calf ... | |
| 1993 | M S Chen, R T Suttmann, E Papp, P D Cannon, M J McRoberts, C Bach, William C Copeland, Teresa S-F Wang | Selective action of 4'-azidothymidine... | |
| 1993 | R K Singhal, Samuel H Wilson | Short gap-filling synthesis by DNA po... | Full length or truncated,Processivity,Gap fill,All properties |
| 1992 | Masamitsu Yamaguchi, Y Hayashi, Fumiko Hirose, K Shiroki, Akio Matsukage | Activation of the mouse DNA polymeras... | |
| 1992 | William C Copeland, M S Chen, Teresa S-F Wang | Human DNA polymerases alpha and beta ... | Cloned or native,Tagged,Full length or truncated,KM,Kd,Vmax,Application name,Incorporation of non-standard nucleotides,All properties |
| 1992 | T Date, K Tanihara, S Yamamoto, N Nomura, Akio Matsukage | Two regions in human DNA polymerase b... | |
| 1992 | DNA Replication | ||
| 1991 | K B Frank, G J Noll, E V Connell, I S Sim | Kinetic interaction of human immunode... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1990 | E W Englander, Samuel H Wilson | Protein binding elements in the human... | |
| 1989 | J E Reardon | Herpes simplex virus type 1 and human... | |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1988 | J Abbotts, Dibyendu Narayan SenGupta, B Z Zmudzka, S G Widen, V Notario, Samuel H Wilson | Expression of human DNA polymerase be... | Cloned or native,Full length or truncated,Processivity,Nick Extension,Gap fill,3-5' exo,5-3' exo,Molecular Weight,All properties |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1987 | R S Anderson, C B Lawrence, Samuel H Wilson, K L Beattie | Genetic relatedness of human DNA poly... | |
| 1986 | Akio Matsukage, Masamitsu Yamaguchi, K R Utsumi, Y Hayashi, R Ueda, M C Yoshida | Assignment of the gene for human DNA ... | |
| 1986 | Dibyendu Narayan SenGupta, B Z Zmudzka, P Kumar, F Cobianchi, J Skowronski, Samuel H Wilson | Sequence of human DNA polymerase beta... | |
| 1985 | Thomas A Kunkel | The mutational specificity of DNA pol... | Gap fill,Overall Error Rate,All properties |
| 1985 | J B Mitchell, E Karawya, T J Kinsella, Samuel H Wilson | Measurement of DNA polymerase beta in... | |
| 1982 | Teresa S-F Wang, D Korn | Specificity of the catalytic interact... | |
| 1981 | N Hardt, G Pedrali-Noy, Federico Focher, Silvio Spadari | Aphidicolin does not inhibit DNA repa... | |
| 1980 | G Pedrali-Noy, Silvio Spadari | Mechanism of inhibition of herpes sim... | |
| 1979 | Ulrich Hübscher, C C Kuenzle, W Limacher, P Scherrer, Silvio Spadari | Functions of DNA polymerases alpha, b... | |
| 1979 | E A Popenoe, M A Schmaeler | Interaction of human DNA polymerase b... | |
| 1979 | P F Pignatti, E Cassai, U Bertazzoni | Herpes simplex virus DNA synthesis in... | |
| 1979 | J Waser, Ulrich Hübscher, C C Kuenzle, Silvio Spadari | DNA polymerase beta from brain neuron... | |
| 1979 | G Pedrali-Noy, Silvio Spadari | Effect of aphidicolin on viral and hu... | |
| 1979 | Ulrich Hübscher, C C Kuenzle, Silvio Spadari | Functional roles of DNA polymerases b... | |
| 1978 | T Shimada, Masami Yamada, M Miwa, H Nagano, Y Mano | Differential susceptibilities of DNA ... | |
| 1978 | Mochihiko Ohashi, Takahiko Taguchi, S Ikegami | Aphidicolin: a specific inhibitor of ... | |
| 1978 | R Dicioccio, B I Srivastava | Inhibition of deoxyribonucleic acid p... | |
| 1978 | P Bhattacharya, S Basu | DNA polymerase activities in differen... | |
| 1978 | Robert A Bambara, D Uyemura, T Choi | On the processive mechanism of Escher... | Full length or truncated,Processivity,All properties |
| 1977 | D C Eichler, Teresa S-F Wang, D A Clayton, D Korn | In vitro replication of mitochondrial... | |
| 1977 | Ulrich Hübscher, C C Kuenzle, Silvio Spadari | Variation of DNA polymerases-alpha, -... | |
| 1976 | D W Mosbaugh, Thomas A Kunkel, D M Stalker, J E Tcheng, R R Meyer | Novikoff hepatoma deoxyribonucleic ac... | |
| 1976 | L M Chang | Phylogeny of DNA polymerase-beta. | |
| 1976 | U Bertazzoni, M Stefanini, G P Noy, E Giulotto, F Nuzzo, A Falaschi, Silvio Spadari | Variations of DNA polymerase-alpha an... | |
| 1975 | R G Smith, J W Abrell, B J Lewis, R C Gallo | Serological analysis of human deoxyri... | |
| 1975 | Silvio Spadari, A Weissbach | RNA-primed DNA synthesis: specific ca... | |
| 1975 | R J Mayer, R G Smith, R C Gallo | DNA-metabolizing enzymes in normal hu... | |
| 1975 | R W Chiu, E F Baril | Nuclear DNA polymerases and the HeLa ... | |
| 1975 | G M Brun, L M Assairi, F Chapeville | Immunological relationships between c... | |
| 1974 | Silvio Spadari, R Muller, A Weissbach | The dissimilitude of the low and high... | |
| 1974 | Silvio Spadari, A Weissbach | The interrelation between DNA synthes... | |
| 1973 | L M Chang, M Brown, F J Bollum | Induction of DNA polymerase in mouse ... | |
| 1973 | L H Lazarus, N Kitron | Letter: Cytoplasmic DNA polymerase: p... | |
| 1973 | N B Hecht | Interconvertibility of mouse DNA poly... | |
| 1973 | R A Bucknall, H Moores, R Simms, B Hesp | Antiviral effects of aphidicolin, a n... | |
| 1973 | E F Baril, M D Jenkins, O E Brown, J Laszlo, H P Morris | DNA polymerases I and II in regenerat... | |
| 1972 | B Fridlender, M Fry, A Bolden, A Weissbach | A new synthetic RNA-dependent DNA pol... | |
| 1972 | L M Chang, F J Bollum | Low molecular weight deoxyribonucleic... | |
| 1972 | L M Chang, F J Bollum | Antigenic relationships in mammalian ... | |
| 1971 | E F Baril, O E Brown, M D Jenkins, J Laszlo | Deoxyribonucleic acid polymerase with... | |
| 1971 | A Weissbach, A Schlabach, B Fridlender, A Bolden | DNA polymerases from human cells. | |
| 1971 | L M Chang, F J Bollum | Low molecular weight deoxyribonucleic... | |
| 1971 | M E. Haines, A M. Holmes, I R. Johnston | Distinct cytoplasmic and nuclear DNA ... |
Protein sequence:
DNA sequence:
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Human Pol beta D160N | |||||
| Human Pol beta G231D | |||||
| Pol beta E232K | |||||
| Pol beta T233I | |||||
| Human Pol beta D256A | |||||
| Human Pol beta D256E | |||||
| Pol beta I260Q | |||||
| Human Pol beta I260M | |||||
| Human Pol beta P261L/T292A/I298T | |||||
| Human Pol beta R283K | |||||
| Human Pol beta E288K | |||||
| Human Pol beta E295K | |||||
| Human Pol beta T304I | |||||
| Human Pol beta E309K | |||||
| Human Pol beta E316RR333E | |||||
| Human Pol beta E316R | |||||
| Human Pol beta R333E | |||||
| Human Pol beta elta 208-304 |
Protein information: Uniprot P06746 search for Human Pol beta at UniProt
Sequence information: NCBI nucleotides European nucleotide archive