Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase.

Fisher MA, Yadav PN, Yadav J, Kristol D, Arnold E, Modak MJ
Journal of molecular recognition : JMR (1994), Volume 7, Page 211
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Abstract:

An 'active analog' approach to receptor mapping was used to identify a ...
An 'active analog' approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4', and O5' atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.

Polymerases:

HIV RT

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