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Modak MJ

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Publications:

Title Authors Year Journal
Characterization of catalytic carboxylate triad in non-replicative DNA polymerase III (pol E) of Geobacillus kaustophilus HTA. Modak MJ 2012 Cellular and molecular biology (Noisy-le-Grand, France)
A new DNA polymerase I from Geobacillus caldoxylosilyticus TK4: cloning, characterization, and mutational analysis of two aromatic residues. Modak MJ 2009 Appl Microbiol Biotechnol
Identification of a new motif required for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): the RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex. Modak MJ 2008 The Journal of biological chemistry
Participation of the fingers subdomain of Escherichia coli DNA polymerase I in the strand displacement synthesis of DNA. Modak MJ 2007 The Journal of biological chemistry
Contribution of polar residues of the J-helix in the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch. Modak MJ 2005 Biochemistry
Phe 771 of Escherichia coli DNA polymerase I (Klenow fragment) is the major site for the interaction with the template overhang and the stabilization of the pre-polymerase ternary complex. Modak MJ 2003 Biochemistry
Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex. Modak MJ 2003 The Journal of biological chemistry
Participation of active-site carboxylates of Escherichia coli DNA polymerase I (Klenow fragment) in the formation of a prepolymerase ternary complex. Modak MJ 2002 Biochemistry
Lysine 152 of MuLV reverse transcriptase is required for the integrity of the active site. Modak MJ 2002 Biochemistry
DNA polymerase I of Mycobacterium tuberculosis: functional role of a conserved aspartate in the hinge joining the M and N helices. Modak MJ 2002 The Journal of biological chemistry
Valine of the YVDD motif of moloney murine leukemia virus reverse transcriptase: role in the fidelity of DNA synthesis. Modak MJ 2000 Biochemistry
Role of Q190 of MuLV RT in ddNTP resistance and fidelity of DNA synthesis: a molecular model of interactions with substrates. Modak MJ 2000 Protein engineering
The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'- 5'-exonuclease functions. Modak MJ 2000 The Journal of biological chemistry
A carboxylate triad is essential for the polymerase activity of Escherichia coli DNA polymerase I (Klenow fragment). Presence of two functional triads at the catalytic center. Modak MJ 2000 The Journal of biological chemistry
Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center. Modak MJ 1999 Biochemistry
Analysis of the role of glutamine 190 in the catalytic mechanism of murine leukemia virus reverse transcriptase. Modak MJ 1999 The Journal of biological chemistry
A unified DNA- and dNTP-binding mode for DNA polymerases. Modak MJ 1998 Trends in biochemical sciences
Polyamide nucleic acid-DNA chimera lacking the phosphate backbone are novel primers for polymerase reaction catalyzed by DNA polymerases. Modak MJ 1998 Biochemistry
Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis. Modak MJ 1997 Biochemistry
Significance of the O-helix residues of Escherichia coli DNA polymerase I in DNA synthesis: dynamics of the dNTP binding pocket. Modak MJ 1996 Biochemistry
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Modak MJ 1996 Biochemistry
Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase. Modak MJ 1996 Biochemistry
Elucidation of the role of Arg 110 of murine leukemia virus reverse transcriptase in the catalytic mechanism: biochemical characterization of its mutant enzymes. Modak MJ 1996 Biochemistry
Mechanism of polyoxometalate-mediated inactivation of DNA polymerases: an analysis with HIV-1 reverse transcriptase indicates specificity for the DNA-binding cleft. Modak MJ 1996 Biochem J
Nucleoside drug resistance in HIV-1 reverse transcriptase. Modak MJ 1995 Nature structural biology
Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity. Modak MJ 1995 The Journal of biological chemistry
Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Modak MJ 1995 Biochemistry
Photoaffinity labeling of DNA template-primer binding site in Escherichia coli DNA polymerase I. Identification of involved amino acids. Modak MJ 1994 The Journal of biological chemistry
Properties of tyrosine 766-->serine mutant of Escherichia coli DNA polymerase I: template-specific effects. Modak MJ 1994 Biochemistry
Identification and analysis of a template-primer (ds-DNA) binding cleft in E. coli DNA polymerase I: an electrostatic potential contour pattern of the modeled structure. Modak MJ 1994 J Mol Recognit
A computer-assisted analysis of conserved residues in the three-dimensional structures of the polymerase domains of Escherichia coli DNA polymerase I and HIV-1 reverse transcriptase. Modak MJ 1994 The Journal of biological chemistry
Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase. Modak MJ 1994 Journal of molecular recognition : JMR
Role of lysine 758 of Escherichia coli DNA polymerase I as assessed by site-directed mutagenesis. Modak MJ 1994 The Journal of biological chemistry
Site directed mutagenesis of DNA polymerase I (Klenow) from Escherichia coli. The significance of Arg682 in catalysis. Modak MJ 1993 Eur J Biochem
Sulphydryl groups in the template-primer-binding domain of murine leukaemia virus reverse transcriptase. Identification and functional analysis of cysteine-90. Modak MJ 1993 The Biochemical journal
A molecular model of the complete three-dimensional structure of the Klenow fragment of Escherichia coli DNA polymerase I: binding of the dNTP substrate and template-primer. Modak MJ 1992 Biochemistry
Binding of DNA to large fragment of DNA polymerase I: identification of strong and weak electrostatic forces and their biological implications. Modak MJ 1992 J Biomol Struct Dyn
Identification of the primer binding domain in human immunodeficiency virus reverse transcriptase. Modak MJ 1992 Biochemistry
Structure-activity analyses of HIV-1 reverse transcriptase. Modak MJ 1992 Biochemical and biophysical research communications
Ferrate oxidation of murine leukemia virus reverse transcriptase: identification of the template-primer binding domain. Modak MJ 1991 Biochemistry
Photoaffinity labeling of the primer binding domain in murine leukemia virus reverse transcriptase. Modak MJ 1991 Biochemistry
Template primer-dependent binding of 5'-fluorosulfonyl-benzoyldeoxyadenosine by Escherichia coli DNA polymerase I. Identification of arginine 682 as the binding site and its implication in catalysis. Modak MJ 1990 The Journal of biological chemistry
Lysine-329 of murine leukemia virus reverse transcriptase: possible involvement in the template-primer binding function. Modak MJ 1990 Biochemistry
Site-directed mutagenesis of Moloney murine leukemia virus reverse transcriptase. Demonstration of lysine 103 in the nucleotide binding site. Modak MJ 1990 The Journal of biological chemistry
Substrate binding in human immunodeficiency virus reverse transcriptase. An analysis of pyridoxal 5'-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain. Modak MJ 1989 The Journal of biological chemistry
Biochemistry of terminal deoxynucleotidyltransferase. Identification and unity of ribo- and deoxyribonucleoside triphosphate binding site in terminal deoxynucleotidyltransferase. Modak MJ 1989 The Journal of biological chemistry
Active-site modification of mammalian DNA polymerase beta with pyridoxal 5'-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket. Modak MJ 1989 Biochemistry
Pyridoxal 5'-phosphate mediated inactivation of Escherichia coli DNA polymerase I: identification of lysine-635 as an essential residue for the processive mode of DNA synthesis. Modak MJ 1988 Biochemistry
Substrate binding domain of murine leukemia virus reverse transcriptase. Identification of lysine 103 and lysine 421 as binding site residues. Modak MJ 1988 The Journal of biological chemistry
Purification of nucleotide-linked peptide. Modak MJ 1988 Journal of chromatography
DNA binding domain of Escherichia coli DNA polymerase I: identification of arginine-841 as an essential residue. Modak MJ 1988 Biochemistry
Affinity labeling of Escherichia coli DNA polymerase I by 5'-fluorosulfonylbenzoyladenosine. Identification of the domain essential for polymerization and Arg-682 as the site of reactivity. Modak MJ 1988 The Journal of biological chemistry
Photoaffinity labeling of the thymidine triphosphate binding domain in Escherichia coli DNA polymerase I: identification of histidine-881 as the site of cross-linking. Modak MJ 1987 Biochemistry
Ferrate oxidation of Escherichia coli DNA polymerase-I. Identification of a methionine residue that is essential for DNA binding. Modak MJ 1987 The Journal of biological chemistry
Identification and amino acid sequence of the deoxynucleoside triphosphate binding site in Escherichia coli DNA polymerase I. Modak MJ 1987 Biochemistry
Mechanism of o-phenanthroline mediated inhibition of E. coli DNA polymerase I : formation of template-primer-metal-phenanthroline complexes with resultant loss of catalytic activity. Modak MJ 1983 Biochem Biophys Res Commun
The mechanism of inhibition of avian myeloblastosis virus reverse transcriptase by a dialdehyde derivative of ATP. Inactivation of essential sulfhydryl group function. Modak MJ 1983 Biochimica et biophysica acta
Rose Bengal mediated inhibition of DNA polymerases: mechanism of inhibition of avian myeloblastosis virus reverse transcriptase under photooxidative conditions. Modak MJ 1983 Biochemistry
Rose Bengal mediated inhibition of DNA polymerases: mechanism of inhibition of avian myeloblastosis virus reverse transcriptase under nonoxidative conditions. Modak MJ 1982 Biochemistry
The mechanism of inorganic phosphate-mediated inhibition of calf thymus DNA polymerase beta and Rauscher leukemia virus dna polymerase. Modak MJ 1982 Biochem Biophys Res Commun
The artifactual nature of fluoride inhibition of reverse transcriptase and associated ribonuclease H. Modak MJ 1981 Biochemical and biophysical research communications
Divalent cation-dependent pyridoxal 5'-phosphate inhibition of Rauscher leukemia virus DNA polymerase: characterization and mechanism of action. Modak MJ 1981 Biochimica et biophysica acta
Enzymatic activities associated with avian and murine retroviral DNA polymerases. Catalysis of and active site involvement in pyrophosphate exchange and pyrophosphorolysis reactions. Modak MJ 1980 The Journal of biological chemistry
Phenylglyoxal as a template site-specific reagent for DNA and RNA polymerases. Selective inhibition of initiation. Modak MJ 1980 The Journal of biological chemistry
Reverse transcriptase-associated RNase H. Part IV. Pyrophosphate does not inhibit RNase H activity of AMV DNA polymerase. Modak MJ 1979 Biochemical and biophysical research communications
Reverse transcriptase-associated ribonuclease H does not require zinc for catalysis. Modak MJ 1979 The Journal of biological chemistry
Reverse transcriptase-associated RNase H activity. II. Inhibition by natural and synthetic RNA. Modak MJ 1978 Journal of virology
Template-specific requirements for DNA synthesis by the Mason-Pfizer monkey virus DNA polymerase: unique aspects. Modak MJ 1978 Biochimica et biophysica acta
Specific inhibition of DNA polymerase-associated RNase H by DNA. Modak MJ 1977 Journal of virology
Purification and properties of Rauscher leukemia virus DNA polymerase and selective inhibition of mammalian viral reverse transcriptase by inorganic phosphate. Modak MJ 1977 The Journal of biological chemistry
Observations on template-specific conditions for DNA synthesis by avian myeloblastosis virus DNA polymerase. Modak MJ 1976 Nucleic acids research
Purification and properties of murine mammary tumor virus DNA polymerase. Modak MJ 1976 Virology
Purification of avian myeloblastosis virus DNA polymerase by affinity chromatography on polycytidylate-agarose. Modak MJ 1974 Journal of virology
Evidence for allosterism in in vitro DNA synthesis on RNA templates. Modak MJ 1974 Proceedings of the National Academy of Sciences of the United States of America

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