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Joyce CM

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Publications:

Title Authors Year Journal
Kinetic analysis of the unique error signature of human DNA polymerase ν Joyce CM 2011 Biochemistry
Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. Joyce CM 2011 The Journal of biological chemistry
Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Joyce CM 2010 Proceedings of the National Academy of Sciences of the United States of America
UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs. Joyce CM 2010 The Journal of biological chemistry
Techniques used to study the DNA polymerase reaction pathway. Joyce CM 2010 Biochimica et biophysica acta
Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity. Joyce CM 2008 Biochemistry
Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence. Joyce CM 2007 Biochemistry
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Joyce CM 2006 Biochemistry
The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases. Joyce CM 2006 The Journal of biological chemistry
Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity. Joyce CM 2004 Biochemistry
DNA polymerase fidelity: kinetics, structure, and checkpoints. Joyce CM 2004 Biochemistry
Comparative kinetics of nucleotide analog incorporation by vent DNA polymerase. Joyce CM 2004 The Journal of biological chemistry
Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment). Joyce CM 2003 Biochemistry
Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis. Joyce CM 2003 Biochemistry
An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides. Joyce CM 2003 Nucleic acids research
Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation. Joyce CM 2002 Proceedings of the National Academy of Sciences of the United States of America
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting. Joyce CM 2002 Biochemistry
Determinants of DNA mismatch recognition within the polymerase domain of the Klenow fragment. Joyce CM 2002 Biochemistry
The mutational specificity of the Dbh lesion bypass polymerase and its implications. Joyce CM 2002 The Journal of biological chemistry
Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. Joyce CM 2001 The Journal of biological chemistry
3'-5' Exonucleolytic activity of DNA polymerases: structural features that allow kinetic discrimination between ribo- and deoxyribonucleotide residues. Joyce CM 2001 Biochemistry
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli. Joyce CM 2000 The Journal of biological chemistry
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). Joyce CM 1999 The Journal of biological chemistry
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides. Joyce CM 1998 Journal of molecular biology
Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment. Joyce CM 1998 Biochemistry
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3'-5' exonuclease sites of DNA polymerase I (Klenow fragment). Joyce CM 1998 Biochemistry
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides. Joyce CM 1998 Proceedings of the National Academy of Sciences of the United States of America
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. Joyce CM 1997 The Journal of biological chemistry
Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli. Joyce CM 1997 Journal of molecular biology
A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity. Joyce CM 1996 The Journal of biological chemistry
Structure-function analysis of 3'-->5'-exonuclease of DNA polymerases. Joyce CM 1995 Methods in enzymology
Polymerase structures and function: variations on a theme? Joyce CM 1995 J Bacteriol
Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment). Joyce CM 1995 The Journal of biological chemistry
Purification of Escherichia coli DNA polymerase I and Klenow fragment. Joyce CM 1995 Methods in enzymology
Function and structure relationships in DNA polymerases. Joyce CM 1994 Annu Rev Biochem
Re-engineering the polymerase domain of Klenow fragment and evaluation of overproduction and purification strategies. Joyce CM 1993 Nucleic acids research
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. Joyce CM 1992 The Journal of biological chemistry
Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment). Joyce CM 1992 The Journal of biological chemistry
The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction. Joyce CM 1991 The EMBO journal
Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). Joyce CM 1991 Biochemistry
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli. Joyce CM 1990 The Journal of biological chemistry
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. Joyce CM 1990 The Journal of biological chemistry
How DNA travels between the separate polymerase and 3'-5'-exonuclease sites of DNA polymerase I (Klenow fragment). Joyce CM 1989 The Journal of biological chemistry
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Joyce CM 1988 Science
Novel blunt-end addition reactions catalyzed by DNA polymerase I of Escherichia coli. Joyce CM 1987 Journal of molecular biology
Functional implications of the Klenow fragment structure. Joyce CM 1986 Biochem Soc Trans
A domain of the Klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity. Joyce CM 1986 Proteins
Genetic mapping and DNA sequence analysis of mutations in the polA gene of Escherichia coli. Joyce CM 1985 Journal of molecular biology
Method for determining whether a gene of Escherichia coli is essential: application to the polA gene. Joyce CM 1984 J Bacteriol
Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli. Joyce CM 1983 Proceedings of the National Academy of Sciences of the United States of America
Genetic characterization of early amber mutations in the Escherichia coli polA gene and purification of the amber peptides. Joyce CM 1983 Journal of molecular biology
Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I. Joyce CM 1982 The Journal of biological chemistry
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