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Benkovic SJ

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Publications:

Title Authors Year Journal
DNA polymerase as a molecular motor and pump. Benkovic SJ 2014 ACS nano
The human lagging strand DNA polymerase δ holoenzyme is distributive. Benkovic SJ 2012 The Journal of biological chemistry
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Benkovic SJ 2009 Nat Chem Biol
Investigation of stoichiometry of T4 bacteriophage helicase loader protein (gp59). Benkovic SJ 2009 The Journal of biological chemistry
RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. Benkovic SJ 2008 The Journal of biological chemistry
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Benkovic SJ 2008 Proceedings of the National Academy of Sciences of the United States of America
The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. Benkovic SJ 2007 The Journal of biological chemistry
Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Benkovic SJ 2006 Biochemistry
Site-directed mutations of T4 helicase loading protein (gp59) reveal multiple modes of DNA polymerase inhibition and the mechanism of unlocking by gp41 helicase. Benkovic SJ 2006 The Journal of biological chemistry
Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Benkovic SJ 2005 Biochemistry
Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Benkovic SJ 2005 Biochemistry
The dynamic processivity of the T4 DNA polymerase during replication. Benkovic SJ 2004 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase fidelity: kinetics, structure, and checkpoints. Benkovic SJ 2004 Biochemistry
Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. Benkovic SJ 2003 The Journal of biological chemistry
The application of a minicircle substrate in the study of the coordinated T4 DNA replication. Benkovic SJ 2003 The Journal of biological chemistry
Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme. Benkovic SJ 2001 The Journal of biological chemistry
Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer. Benkovic SJ 2001 Proceedings of the National Academy of Sciences of the United States of America
Dynamic protein interactions in the bacteriophage T4 replisome. Benkovic SJ 2001 Trends in biochemical sciences
Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly. Benkovic SJ 2000 Biochemistry
The carboxyl terminus of the bacteriophage T4 DNA polymerase contacts its sliding clamp at the subunit interface. Benkovic SJ 1999 The Journal of biological chemistry
Effect of accessory proteins on T4 DNA polymerase replication fidelity. Benkovic SJ 1998 Journal of molecular biology
Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. Benkovic SJ 1998 Biochemistry
Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. Benkovic SJ 1998 Biochemistry
Kinetic characterization of a bacteriophage T4 antimutator DNA polymerase. Benkovic SJ 1998 Biochemistry
Assembly and disassembly of DNA polymerase holoenzyme. Benkovic SJ 1997 Curr Opin Chem Biol
Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis. Benkovic SJ 1997 Biochemistry
Mechanism of bacteriophage T4 DNA holoenzyme assembly: the 44/62 protein acts as a molecular motor. Benkovic SJ 1997 Biochemistry
The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation. Benkovic SJ 1996 Proceedings of the National Academy of Sciences of the United States of America
Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. Benkovic SJ 1996 The Journal of biological chemistry
Elucidation of the metal-binding properties of the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase by lanthanide(III) luminescence spectroscopy. Benkovic SJ 1996 Chemistry & biology
Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I. Benkovic SJ 1995 Methods in enzymology
Accessory proteins function as matchmakers in the assembly of the T4 DNA polymerase holoenzyme. Benkovic SJ 1995 Current biology : CB
Photochemical cross-linking of DNA replication proteins at primer terminus. Benkovic SJ 1995 Methods in enzymology
Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer. Benkovic SJ 1995 The Journal of biological chemistry
The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase. Benkovic SJ 1995 Biochemistry
Spatial relationship between polymerase and exonuclease active sites of phage T4 DNA polymerase enzyme. Benkovic SJ 1994 The Journal of biological chemistry
Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity. Benkovic SJ 1993 Proceedings of the National Academy of Sciences of the United States of America
Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct. Benkovic SJ 1993 Proceedings of the National Academy of Sciences of the United States of America
Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities. Benkovic SJ 1992 Proceedings of the National Academy of Sciences of the United States of America
Minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment). Benkovic SJ 1992 Biochemistry
Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4. Benkovic SJ 1992 Biochemistry
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. Benkovic SJ 1992 The Journal of biological chemistry
Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Benkovic SJ 1992 Science
Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant. Benkovic SJ 1991 Biochemistry
Protein-DNA cross-linking demonstrates stepwise ATP-dependent assembly of T4 DNA polymerase and its accessory proteins on the primer-template. Benkovic SJ 1991 Cell
Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). Benkovic SJ 1991 Biochemistry
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity. Benkovic SJ 1991 Biochemistry
Interaction of DNA with the Klenow fragment of DNA polymerase I studied by time-resolved fluorescence spectroscopy. Benkovic SJ 1991 Biochemistry
Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts. Benkovic SJ 1990 Biochemistry
Resonance energy transfer measurements between substrate binding sites within the large (Klenow) fragment of Escherichia coli DNA polymerase I. Benkovic SJ 1989 Biochemistry
Fluorescent oligonucleotides and deoxynucleotide triphosphates: preparation and their interaction with the large (Klenow) fragment of Escherichia coli DNA polymerase I. Benkovic SJ 1989 Biochemistry
Inactivation of DNA polymerase I (Klenow fragment) by adenosine 2',3'-epoxide 5'-triphosphate: evidence for the formation of a tight-binding inhibitor. Benkovic SJ 1989 Biochemistry
Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. Benkovic SJ 1988 Biochemistry
Kinetic mechanism of DNA polymerase I (Klenow). Benkovic SJ 1987 Biochemistry
Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions. Benkovic SJ 1986 Proceedings of the National Academy of Sciences of the United States of America
Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I. Benkovic SJ 1986 Proceedings of the National Academy of Sciences of the United States of America
Rate-limiting steps in the DNA polymerase I reaction pathway. Benkovic SJ 1985 Biochemistry
Continuous assay for DNA polymerization by light scattering. Benkovic SJ 1984 Analytical biochemistry
Stereochemical course of the 3'----5'-exonuclease activity of DNA polymerase I. Benkovic SJ 1984 Biochemistry
The effect of the 3',5' thiophosphoryl linkage on the exonuclease activities of T4 polymerase and the Klenow fragment. Benkovic SJ 1984 Nucleic acids research
Elementary steps in the DNA polymerase I reaction pathway. Benkovic SJ 1983 Biochemistry
Template-prime-dependent turnover of (Sp)-dATP alpha S by T4 DNA polymerase. The stereochemistry of the associated 3' goes to 5'-exonuclease. Benkovic SJ 1982 The Journal of biological chemistry

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