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Konigsberg WH

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Publications:

Title Authors Year Journal
Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Konigsberg WH 2013 Nucleic acids research
Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Konigsberg WH 2012 Biochemistry
Contribution of Partial Charge Interactions and Base-Stacking to the Efficiency of Primer-Extension at and beyond Abasic Sites in DNA. Konigsberg WH 2012 Biochemistry
Bidendate and tridendate metal-ion coordination states within ternary complexes of RB69 DNA polymerase. Konigsberg WH 2012 Protein science : a publication of the Protein Society
Using a Fluorescent Cytosine Analogue tC(o) To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase. Konigsberg WH 2012 Biochemistry
DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase. Konigsberg WH 2012 Journal of the American Chemical Society
Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. Konigsberg WH 2011 Journal of molecular biology
Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Konigsberg WH 2011 Biochemistry
Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. Konigsberg WH 2011 Journal of the American Chemical Society
Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase. Konigsberg WH 2011 Biochemistry
Insights into Base Selectivity from the 1.8 A Resolution Structure of an RB69 DNA Polymerase Ternary Complex. Konigsberg WH 2011 Biochemistry
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Konigsberg WH 2010 Biochemistry
Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin . Konigsberg WH 2010 Biochemistry
The reopening rate of the fingers domain is a determinant of base selectivity for RB69 DNA polymerase. Konigsberg WH 2009 Biochemistry
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Konigsberg WH 2009 Nature structural & molecular biology
Effect of A and B metal ion site occupancy on conformational changes in an RB69 DNA polymerase ternary complex. Konigsberg WH 2009 Biochemistry
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity. Konigsberg WH 2009 Biochemistry
Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. Konigsberg WH 2007 The Journal of biological chemistry
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Konigsberg WH 2007 Proceedings of the National Academy of Sciences of the United States of America
Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Konigsberg WH 2007 Proceedings of the National Academy of Sciences of the United States of America
The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Konigsberg WH 2006 Biochemistry
Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site. Konigsberg WH 2005 Biochemistry
The activity of selected RB69 DNA polymerase mutants can be restored by manganese ions: the existence of alternative metal ion ligands used during the polymerization cycle. Konigsberg WH 2004 Biochemistry
Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity. Konigsberg WH 2004 Biochemistry
Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins. Konigsberg WH 2002 Genetics
Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure. Konigsberg WH 2002 Biochemistry
A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase. Konigsberg WH 2002 Biochemistry
3'-5' Exonucleolytic activity of DNA polymerases: structural features that allow kinetic discrimination between ribo- and deoxyribonucleotide residues. Konigsberg WH 2001 Biochemistry
Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. Konigsberg WH 2001 The Journal of biological chemistry
DNA polymerase of the T4-related bacteriophages. Konigsberg WH 2000 Prog Nucleic Acid Res Mol Biol
Steady-state kinetic characterization of RB69 DNA polymerase mutants that affect dNTP incorporation. Konigsberg WH 1999 Biochemistry
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Konigsberg WH 1997 Cell
Residues at the carboxy terminus of T4 DNA polymerase are important determinants for interaction with the polymerase accessory proteins. Konigsberg WH 1997 Biochemistry
Functional consequences and exonuclease kinetic parameters of point mutations in bacteriophage T4 DNA polymerase. Konigsberg WH 1996 Biochemistry
Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions. Konigsberg WH 1996 Biochemistry
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA. Konigsberg WH 1995 Nature
Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3'-5' exonuclease activity. Konigsberg WH 1994 The Journal of biological chemistry
DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies. Konigsberg WH 1991 Proceedings of the National Academy of Sciences of the United States of America
Photoaffinity labeling of the Klenow fragment with 8-azido-dATP. Konigsberg WH 1990 The Journal of biological chemistry
Rapid purification of overexpressed T4 DNA polymerase. Konigsberg WH 1989 Prep Biochem
The 44P subunit of the T4 DNA polymerase accessory protein complex catalyzes ATP hydrolysis. Konigsberg WH 1989 The Journal of biological chemistry
Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases. Konigsberg WH 1988 The Journal of biological chemistry
Cloning and expression of T4 DNA polymerase. Konigsberg WH 1987 Proceedings of the National Academy of Sciences of the United States of America

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