Human Pol epsilon

From H. sapiens (aliases:Hsa pol epsilon) (genes: POLE)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol epsilon.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol epsilon is a family B enzyme from H. sapiens.

Selected Properties for Human Pol epsilon:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (6) No (3) no data no data no data
Year Authors Title Results by property
2013 Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani The Human Tim/Tipin Complex Directly ...
2013 Walter J Zahurancik, Seth J Klein, Zucai Suo Kinetic Mechanism of DNA Polymerizati...
2012 Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja Segregation of replicative DNA polyme...
2011 Alan B Clark, Scott A Lujan, Grace E Kissling, Thomas A Kunkel Mismatch repair-independent tandem re...
2011 Dagmara A Korona, Kimberly G Lecompte, Zachary F Pursell The high fidelity and unique error si...
2010 Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich Continued primer synthesis at stalled...
2010 Stephanie A Nick McElhinny, Brian E Watts, Dinesh Kumar, Danielle L Watt, Else-Britt Lundström, Peter M J Burgers, Erik Johansson, Andrei Chabes, Thomas A Kunkel Abundant ribonucleotide incorporation...
2010 Mark D Sutton Coordinating DNA polymerase traffic d...
2009 Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina Structure and activity relationship o...
2009 Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin Evolution of DNA polymerases: an inac... 3-5' exo,5-3' exo,All properties
2008 Tarmo Nuutinen, Helena Tossavainen, Kai Fredriksson, Päivi Pirilä, Perttu Permi, Helmut Pospiech, Juhani E Syvaoja The solution structure of the amino-t...
2006 Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja DNA polymerase epsilon associates wit... Other accessory protein(s),All properties
2004 Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel Evidence for interplay among yeast re... 3-5' exo,5-3' exo,All properties
2004 Masahiko Oshige, Ryo Takeuchi, Tatsuji Ruike, Ryuji Ruike, Kazufumi Kuroda, Kengo Sakaguchi Subunit protein-affinity isolation of... 3-5' exo,All properties
2003 Yoshiyuki Mizushina, Xianai Xu, Hitomi Asahara, Ryo Takeuchi, Masahiko Oshige, Noriko Shimazaki, Masaharu Takemura, Tsuyoshi Yamaguchi, Kazufumi Kuroda, Stuart Linn, Hiromi Yoshida, Osamu Koiwai, Mineo Saneyoshi, Fumio Sugawara, Kengo Sakaguchi A sulphoquinovosyl diacylglycerol is ...
2003 Hitomi Asahara, Yingqian Li, Jill Fuss, Dale S Haines, Nikolina Vlatkovic, Mark T Boyd, Stuart Linn Stimulation of human DNA polymerase e...
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Eukaryotic DNA polymerases.
2002 Jill Fuss, Stuart Linn Human DNA polymerase epsilon colocali...
2002 Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Tomomi Ishidoh, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi Petasiphenol: a DNA polymerase lambda...
2000 S W Wang, T Toda, R MacCallum, A L Harris, C Norbury Cid1, a fission yeast protein require...
2000 W Liu, Stuart Linn Proteolysis of the human DNA polymera...
1999 T A Winters, P S Russell, M Kohli, M E Dar, R D Neumann, T J Jorgensen Determination of human DNA polymerase...
1999 Helmut Pospiech, I Kursula, Waleed Abdel-Aziz, Linda Malkas, L Uitto, M Kastelli, M Vihinen-Ranta, S Eskelinen, Juhani E Syväoja A neutralizing antibody against human...
1998 Maarit Jokela, M Mäkiniemi, S Lehtonen, C Szpirer, U Hellman, Juhani E Syväoja The small subunits of human and mouse...
1998 A Tomikawa, M Seno, K Sato-Kiyotaki, C Ohtsuki, T Hirai, Tsuyoshi Yamaguchi, T Kawaguchi, Shonen Yoshida, Mineo Saneyoshi Synthetic nucleosides and nucleotides...
1997 Yingqian Li, Hitomi Asahara, V S Patel, S Zhou, Stuart Linn Purification, cDNA cloning, and gene ...
1996 S Ceccotti, G Aquilina, Peter Macpherson, Masami Yamada, Peter Karran, Margherita Bignami Processing of O6-methylguanine by mis...
1996 Dmitry Ju Mozzherin, Paul A Fisher Human DNA polymerase epsilon: enzymol...
1996 F B Perler, Sandeep Kumar, H Kong Thermostable DNA polymerases. Full length or truncated,3-5' exo,5-3' exo,All properties
1996 Kenji Kamiya, P Huang, W Plunkett Inhibition of the 3' --> 5' exonuclea...
1996 Polina V Shcherbakova, V N Noskov, M R Pshenichnov, Youri I Pavlov Base analog 6-N-hydroxylaminopurine m...
1995 G Chui, Stuart Linn Further characterization of HeLa DNA ... Cloned or native,Tagged,Full length or truncated,Extension from RNA primer,Percent/Fold Effect,All properties
1995 T A Navas, Z Zhou, S J Elledge DNA polymerase epsilon links the DNA ...
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Stereospecificity of human DNA polyme...
1994 Xincang Li, Peter M J Burgers Molecular cloning and expression of t...
1994 L M Podust, Vladimir N Podust, C Floth, Ulrich Hübscher Assembly of DNA polymerase delta and ...
1993 Tapio Kesti, H Frantti, Juhani E Syväoja Molecular cloning of the cDNA for the...
1993 Vladimir N Podust, Ulrich Hübscher Lagging strand DNA synthesis by calf ...
1992 L Uitto, J Halleen, P Remes, Tapio Kesti, Juhani E Syväoja The 3'-->5' exonuclease associated wi...
1992 Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick Transposon Tn5 excision in yeast: inf...
1992 DNA Replication
1992 Hiroyuki Araki, P A Ropp, A L Johnson, L H Johnston, A Morrison, Akio Sugino DNA polymerase II, the probable homol...
1992 H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee Structural and functional relationshi...
1991 T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher Biochemical and functional comparison... Full length or truncated,Specific Activity,Processivity,3-5' exo,5-3' exo,3-5' Exo Specific Activity,RNase H,All properties
1991 Sang Hee Lee, Z Q Pan, A D Kwong, Peter M J Burgers, Jerard Hurwitz Synthesis of DNA by DNA polymerase ep...
1991 Alessandra Montecucco, M Fontana, Federico Focher, M Lestingi, Silvio Spadari, G Ciarrocchi Specific inhibition of human DNA liga...
1990 Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari Revised nomenclature for eukaryotic D...
1989 J Syvaoja, Stuart Linn Characterization of a large form of D... Cloned or native,Tagged,Full length or truncated,Specific Activity,Processivity,3-5' exo,KM,Molecular Weight,All properties
1987 Marietta Y W T Lee, N L Toomey Human placental DNA polymerase delta:...
1981 M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari An autoradiographic demonstration of ...
1980 G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch Synchronization of HeLa cell cultures...
Protein sequence:

Predicted Structure Model

Predicted model AlphaFold DB Not experimentally determined

This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)

Confidence legend (pLDDT)

AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.

  • Very high (pLDDT > 90) Backbone and side chains are usually reliable.
  • Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
  • Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
  • Very low (pLDDT < 50) Often disordered or not confidently placed.
2V6Z

Version:20260603

Using Polbase tables:

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