Human Pol epsilon

From H. sapiens (aliases:Hsa pol epsilon) (genes: POLE)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol epsilon.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol epsilon is a family B enzyme from H. sapiens.

Selected Properties for Human Pol epsilon:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (6) No (3) no data no data no data
Year Authors Title Results by property
2013 Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani Aria V2013
2013 Walter J Zahurancik, Seth J Klein, Zucai Suo Zahurancik WJ2013
2012 Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja Vaara M2012
2011 Alan B Clark, Scott A Lujan, Grace E Kissling, Thomas A Kunkel Clark AB2011
2011 Dagmara A Korona, Kimberly G Lecompte, Zachary F Pursell Korona DA2011
2010 Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich Van C2010
2010 Stephanie A Nick McElhinny, Brian E Watts, Dinesh Kumar, Danielle L Watt, Else-Britt Lundström, Peter M J Burgers, Erik Johansson, Andrei Chabes, Thomas A Kunkel Nick McElhinny SA2010
2010 Mark D Sutton Sutton MD2010
2009 Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina Matsui Y2009
2009 Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin Tahirov TH2009 3-5' exo,5-3' exo,All properties
2008 Tarmo Nuutinen, Helena Tossavainen, Kai Fredriksson, Päivi Pirilä, Perttu Permi, Helmut Pospiech, Juhani E Syvaoja Nuutinen T2008
2006 Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja Rytkönen AK2006 Other accessory protein(s),All properties
2004 Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel Pavlov YI2004 3-5' exo,5-3' exo,All properties
2004 Masahiko Oshige, Ryo Takeuchi, Tatsuji Ruike, Ryuji Ruike, Kazufumi Kuroda, Kengo Sakaguchi Oshige M2004 3-5' exo,All properties
2003 Yoshiyuki Mizushina, Xianai Xu, Hitomi Asahara, Ryo Takeuchi, Masahiko Oshige, Noriko Shimazaki, Masaharu Takemura, Tsuyoshi Yamaguchi, Kazufumi Kuroda, Stuart Linn, Hiromi Yoshida, Osamu Koiwai, Mineo Saneyoshi, Fumio Sugawara, Kengo Sakaguchi Mizushina Y2003
2003 Hitomi Asahara, Yingqian Li, Jill Fuss, Dale S Haines, Nikolina Vlatkovic, Mark T Boyd, Stuart Linn Asahara H2003
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Hubscher U2002
2002 Jill Fuss, Stuart Linn Fuss J2002
2002 Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Tomomi Ishidoh, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi Mizushina Y2002
2000 S W Wang, T Toda, R MacCallum, A L Harris, C Norbury Wang SW2000
2000 W Liu, Stuart Linn Liu W2000
1999 T A Winters, P S Russell, M Kohli, M E Dar, R D Neumann, T J Jorgensen Winters TA1999
1999 Helmut Pospiech, I Kursula, Waleed Abdel-Aziz, Linda Malkas, L Uitto, M Kastelli, M Vihinen-Ranta, S Eskelinen, Juhani E Syväoja Pospiech H1999
1998 Maarit Jokela, M Mäkiniemi, S Lehtonen, C Szpirer, U Hellman, Juhani E Syväoja Jokela M1998
1998 A Tomikawa, M Seno, K Sato-Kiyotaki, C Ohtsuki, T Hirai, Tsuyoshi Yamaguchi, T Kawaguchi, Shonen Yoshida, Mineo Saneyoshi Tomikawa A1998
1997 Yingqian Li, Hitomi Asahara, V S Patel, S Zhou, Stuart Linn Li Y1997
1996 S Ceccotti, G Aquilina, Peter Macpherson, Masami Yamada, Peter Karran, Margherita Bignami Ceccotti S1996
1996 Dmitry Ju Mozzherin, Paul A Fisher Mozzherin DJ1996
1996 F B Perler, Sandeep Kumar, H Kong Perler FB1996 Full length or truncated,3-5' exo,5-3' exo,All properties
1996 Kenji Kamiya, P Huang, W Plunkett Kamiya K1996
1996 Polina V Shcherbakova, V N Noskov, M R Pshenichnov, Youri I Pavlov Shcherbakova PV1996
1995 G Chui, Stuart Linn Chui G1995 Cloned or native,Tagged,Full length or truncated,Extension from RNA primer,Percent/Fold Effect,All properties
1995 T A Navas, Z Zhou, S J Elledge Navas TA1995
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Focher F1995
1994 Xincang Li, Peter M J Burgers Li X1994
1994 L M Podust, Vladimir N Podust, C Floth, Ulrich Hübscher Podust LM1994
1993 Tapio Kesti, H Frantti, Juhani E Syväoja Kesti T1993
1993 Vladimir N Podust, Ulrich Hübscher Podust VN1993
1992 L Uitto, J Halleen, P Remes, Tapio Kesti, Juhani E Syväoja Uitto L1992
1992 Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick Gordenin DA1992
1992 Unknown1992
1992 Hiroyuki Araki, P A Ropp, A L Johnson, L H Johnston, A Morrison, Akio Sugino Araki H1992
1992 H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee Hao H1992
1991 T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher Weiser T1991 Full length or truncated,Specific Activity,Processivity,3-5' exo,5-3' exo,3-5' Exo Specific Activity,RNase H,All properties
1991 Sang Hee Lee, Z Q Pan, A D Kwong, Peter M J Burgers, Jerard Hurwitz Lee SH1991
1991 Alessandra Montecucco, M Fontana, Federico Focher, M Lestingi, Silvio Spadari, G Ciarrocchi Montecucco A1991
1990 Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari Burgers PM1990
1989 J Syvaoja, Stuart Linn Syvaoja J1989 Cloned or native,Tagged,Full length or truncated,Specific Activity,Processivity,3-5' exo,KM,Molecular Weight,All properties
1987 Marietta Y W T Lee, N L Toomey Lee MY1987
1981 M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari Geuskens M1981
1980 G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch Pedrali-Noy G1980
Protein sequence:
DNA sequence:
All Polymerases | 31 Results

Using Polbase tables:

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