Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.

Abstract:

Human DNA polymerase N (POLN or pol nu) is the most recently ...

Polymerases:

Topics:

Historical Protein Properties (MW, pI, ...), Nucleotide Analogs / Template Lesions, Structure and Structure/Function, Nucleotide Incorporation, Exonuclease Activity

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Molecular Weight 100kD
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. 3-5' Exonuclease (proofreading) No
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Template lesions Stalls Reaction: Nucleotide incorporation; DNA lesion: Apurinic/Apyrimidinic (AP) site
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Template lesions Stalls Reaction: Nucleotide incorporation; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Amino Acids Contacting NTP D623A
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Processivity 150bp
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Nick Extension Yes, via strand displacement
Human Pol nu Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Strand Displacement Yes

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