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Iwai S

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Publications:

Title Authors Year Journal
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Iwai S Nature
A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis. Iwai S 2013 Nucleic acids research
Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer. Iwai S 2011 Nucleic acids research
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. Iwai S 2010 PLoS genetics
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. Iwai S 2010 Journal of nucleic acids
Molecular analyses of an unusual translesion DNA polymerase from Methanosarcina acetivorans C2A. Iwai S 2010 Journal of molecular biology
Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. Iwai S 2010 Carcinogenesis
Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands. Iwai S 2010 Genes to cells : devoted to molecular & cellular mechanisms
Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus. Iwai S 2009 Nucleic acids research
REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo. Iwai S 2008 Nucleic acids research
Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases. Iwai S 2008 Nucleic acids symposium series (2004)
Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins. Iwai S 2008 Biochemistry
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. Iwai S 2007 DNA repair
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Iwai S 2006 The Journal of biological chemistry
DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers. Iwai S 2006 DNA repair
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Iwai S 2006 Molecular cell
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Iwai S 2004 Genes Cells
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Iwai S 2004 Molecular and cellular biology
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Iwai S 2004 Nucleic acids research
High-efficiency bypass of DNA damage by human DNA polymerase Q. Iwai S 2004 The EMBO journal
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Iwai S 2004 Nature
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution. Iwai S 2004 Nat Biotechnol
Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. Iwai S 2003 The Journal of biological chemistry
The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones. Iwai S 2003 The Journal of biological chemistry
Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha. Iwai S 2003 The Journal of biological chemistry
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. Iwai S 2003 DNA repair
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Iwai S 2002 Biochemistry
A role for DNA polymerase beta in mutagenic UV lesion bypass. Iwai S 2002 The Journal of biological chemistry
Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota. Iwai S 2001 The Journal of biological chemistry
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Iwai S 2001 Nucleic acids research
DNA polymerase iota and related rad30-like enzymes. Iwai S 2001 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. Iwai S 2000 The EMBO journal
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. Iwai S 2000 The EMBO journal
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Iwai S 2000 Nucleic acids research
Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase. Iwai S 2000 Cold Spring Harbor symposia on quantitative biology
Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Iwai S 2000 Genes Dev
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Iwai S 1999 Nature
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. Iwai S 1999 The EMBO journal
Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Iwai S 1993 Nucleic acids research
Cloning a defined region of DNA using a limited action of DNA polymerase: application to dissection of hepatitis B virus surface antigen gene. Iwai S 1986 Gene
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