Human Pol gamma
From
H. sapiens
(aliases:h pol gamma, pol gamma, hsa pol gamma)
(genes: POLG)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol gamma.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
NIEHS Pol Gamma Mutation Database: viewAllMutations
Human Pol gamma
is a family A enzyme
from
H. sapiens.
Selected Properties for Human Pol gamma: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Yes (10) | No (2) | 1.2e-06 errors/bp (1) | 1.0e-05-1.0e-05 errors/bp (2) | 1.8e-06-2.9e-04 errors/bp (2) |
- References (62)
- Structures (1)
- Sequences (1)
- Mutants (175)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida | Inhibitory effects of α-mangostin on ... | |
| 2013 | Rajesh Kasiviswanathan, Irina G Minko, R Stephen Lloyd, William C Copeland | Translesion synthesis past acrolein-d... | |
| 2013 | Jeffrey D Stumpf, Russell P Saneto, William C Copeland | Clinical and Molecular Features of PO... | |
| 2013 | Scott R Kennedy, Jesse J Salk, Michael W Schmitt, Lawrence A Loeb | Ultra-Sensitive Sequencing Reveals an... | |
| 2012 | MR Bekheirnia, Weiming Zhang, T Eble, A Willis, A Shaibani, Lee-Jun C Wong, F Scaglia, SU Dhar | POLG mutation in a patient with catar... | |
| 2012 | Deborah L Croteau, Marie L Rossi, Chandrika Canugovi, Jane Tian, Peter Sykora, Mahesh Ramamoorthy, Zhengming Wang, Dharmendra Kumar Singh, Mansour Akbari, Rajesh Kasiviswanathan, William C Copeland, Vilhelm A Bohr | RECQL4 localizes to mitochondria and ... | |
| 2012 | Christal D Sohl, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson | Mutations in human DNA polymerase γ c... | |
| 2012 | Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A Bohr, Ulrich Hübscher, Pavel Janscak | Involvement of Werner syndrome protei... | |
| 2011 | Liliya Euro, Gregory A Farnum, Eino J H Palin, Anu Suomalainen, Laurie S Kaguni | Clustering of Alpers disease mutation... | |
| 2011 | Marcos T Oliveira, Laurie S Kaguni | Reduced stimulation of recombinant Po... | |
| 2011 | Rajesh Kasiviswanathan, Margaret A Gustafson, William C Copeland, Joel N Meyer | Human mitochondrial DNA polymerase γ ... | Cloned or native,Tagged,Tag Name,Full length or truncated,3-5' exo,All properties |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2011 | Neli Atanassova, Javier Miralles Fusté, Sjoerd Wanrooij, Bertil Macao, Steffi Goffart, Stefan Bäckström, Geraldine Farge, Ivan Khvorostov, Nils-Göran Larsson, Johannes N Spelbrink, Maria Falkenberg | Sequence-specific stalling of DNA pol... | |
| 2010 | Eino J H Palin, Annamari Lesonen, Carol L Farr, Liliya Euro, Anu Suomalainen, Laurie S Kaguni | Functional analysis of H. sapiens DNA... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2009 | Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structure and activity relationship o... | |
| 2009 | Young-Sam Lee, W Dexter Kennedy, Y Whitney Yin | Structural insight into processive hu... | Cloned or native,Tagged,Tag Name,Full length or truncated,Polymerase Catalytic Residue Amino Acids,All properties |
| 2009 | Christopher M Bailey, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson | R964C mutation of DNA polymerase gamm... | |
| 2008 | Scott D McCulloch, Thomas A Kunkel | The fidelity of DNA synthesis by euka... | 3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties |
| 2008 | Jason D Fowler, Jessica A Brown, Kenneth A Johnson, Zucai Suo | Kinetic investigation of the inhibito... | |
| 2008 | Patrick P Lestienne, François Boudsocq, Jacques E Bonnet | Initiation of DNA replication by a th... | |
| 2008 | Bartosz Szczesny, Anne W Tann, Matthew J Longley, William C Copeland, Sankar Mitra | Long patch base excision repair in ma... | |
| 2008 | Harold R Lee, Sandra A Helquist, Eric T Kool, Kenneth A Johnson | Importance of hydrogen bonding for ef... | |
| 2007 | Harold R Lee, Kenneth A Johnson | Fidelity and processivity of reverse ... | |
| 2007 | Hikaru Yamanaka, Hiroyuki Gatanaga, Pope Kosalaraksa, Saori Matsuoka-Aizawa, Tomonori Takahashi, Seisuke Kimura, Shinichi Oka | Novel mutation of human DNA polymeras... | |
| 2007 | Elena Yakubovskaya, Mark Lukin, Zhixin Chen, John Berriman, Joseph S Wall, Ryuji Kobayashi, Caroline Kisker, Daniel F Bogenhagen | The EM structure of human DNA polymer... | |
| 2007 | Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya | Activity against human immunodeficien... | |
| 2006 | Li Fan, Sangbumn Kim, Carol L Farr, Kevin T Schaefer, Kathleen M Randolph, John A Tainer, Laurie S Kaguni | A novel processive mechanism for DNA ... | Processivity,3-5' exo,Kd,All properties |
| 2006 | Katarzyna Stopińska, Tomasz Grzybowski, Boris A Malyarchuk, Miroslava V Derenko, Danuta Miścicka-Sliwka | Optimization of the Y831C mutation de... | |
| 2006 | Yuko Yonezawa, Isoko Kuriyama, Atsushi Fukuoh, Tsuyoshi Muta, Dongchon Kang, Masaharu Takemura, Ikunoshin Kato, Hiromi Yoshida, Yoshiyuki Mizushina | Inhibitory effect of coenzyme Q on eu... | |
| 2005 | Sherine S L Chan, Matthew J Longley, William C Copeland | The common A467T mutation in the huma... | |
| 2005 | Matthew J Longley, Maria A Graziewicz, Rachelle J Bienstock, William C Copeland | Consequences of mutations in human DN... | |
| 2004 | Eisuke Murakami, Adrian S Ray, Raymond F Schinazi, Karen S Anderson | Investigating the effects of stereoch... | |
| 2004 | Maria A Graziewicz, Jane M Sayer, Donald M Jerina, William C Copeland | Nucleotide incorporation by human DNA... | |
| 2004 | Kevin A Fiala, Zucai Suo | Pre-steady-state kinetic studies of t... | Overall Error Rate,All properties |
| 2003 | Eisuke Murakami, Joy Y Feng, Harold R Lee, Jeremiah Hanes, Kenneth A Johnson, Karen S Anderson | Characterization of novel reverse tra... | |
| 2003 | Susan E Lim, Mikhail V Ponamarev, Matthew J Longley, William C Copeland | Structural determinants in human DNA ... | |
| 2002 | Christophe Rocher, Thierry Letellier, William C Copeland, Patrick Lestienne | Base composition at mtDNA boundaries ... | |
| 2002 | Vineeta Khare, Kristin A Eckert | The proofreading 3'-->5' exonuclease ... | 3-5' exo,5-3' exo,All properties |
| 2001 | Susan E Lim, William C Copeland | Differential incorporation and remova... | |
| 2001 | Matthew J Longley, Dinh Nguyen, Thomas A Kunkel, William C Copeland | The fidelity of human DNA polymerase ... | Tagged,Tag Name,Full length or truncated,Nucleotide Substitution Rate,Molecular Weight,Nucleotide incorporation accessory protein(s),All properties |
| 2001 | Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter | Mechanism of action of 1-beta-D-2,6-d... | |
| 2001 | Allison A Johnson, Kenneth A Johnson | Fidelity of nucleotide incorporation ... | |
| 2000 | Frank C Richardson, Robert D Kuchta, A Mazurkiewicz, Katherine A Richardson | Polymerization of 2'-fluoro- and 2'-O... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1999 | Susan E Lim, Matthew J Longley, William C Copeland | The mitochondrial p55 accessory subun... | Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,Other accessory protein(s),All properties |
| 1998 | Matthew J Longley, Rajendra Prasad, Deepak K Srivastava, Samuel H Wilson, William C Copeland | Identification of 5'-deoxyribose phos... | |
| 1998 | S W Graves, Allison A Johnson, Kenneth A Johnson | Expression, purification, and initial... | Tagged,Tag Name,Full length or truncated,Processivity,3-5' exo,Kd,kcat,Molecular Weight,Vmax,All properties |
| 1998 | Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland | Characterization of the native and re... | RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties |
| 1998 | Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland | Characterization of the native and re... | RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties |
| 1996 | W Lewis, E S Levine, B Griniuviene, K O Tankersley, J M Colacino, J P Sommadossi, K A Watanabe, Fred W Perrino | Fialuridine and its metabolites inhib... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,All properties |
| 1995 | N M Gray, C L Marr, C R Penn, J M Cameron, R C Bethell | The intracellular phosphorylation of ... | |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1991 | K B Frank, G J Noll, E V Connell, I S Sim | Kinetic interaction of human immunode... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1989 | Thomas A Kunkel, D W Mosbaugh | Exonucleolytic proofreading by a mamm... | 3-5' exo,All properties |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1987 | P Lestienne | Evidence for a direct role of the DNA... | |
| 1979 | P F Pignatti, E Cassai, U Bertazzoni | Herpes simplex virus DNA synthesis in... | |
| 1978 | R Dicioccio, B I Srivastava | Inhibition of deoxyribonucleic acid p... | |
| 1977 | Ulrich Hübscher, C C Kuenzle, Silvio Spadari | Identity of DNA polymerase gamma from... |
Protein sequence:
Pol gamma database record viewAllMutations
Protein information: Uniprot P54098 search for Human Pol gamma at UniProt
Sequence information: NCBI nucleotides European nucleotide archive