Human Pol gamma
From
H. sapiens
(aliases:h pol gamma, pol gamma, hsa pol gamma)
(genes: POLG)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol gamma.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
NIEHS Pol Gamma Mutation Database: viewAllMutations
Human Pol gamma
is a family A enzyme
from
H. sapiens.
Selected Properties for Human Pol gamma: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Yes (10) | No (2) | 1.2e-06 errors/bp (1) | 1.0e-05-1.0e-05 errors/bp (2) | 1.8e-06-2.9e-04 errors/bp (2) |
- References (62)
- Structures (2)
- Sequences (1)
- Mutants (175)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida | Inhibitory effects of α-mangostin on ... | |
| 2013 | Rajesh Kasiviswanathan, Irina G Minko, R Stephen Lloyd, William C Copeland | Translesion synthesis past acrolein-d... | |
| 2013 | Jeffrey D Stumpf, Russell P Saneto, William C Copeland | Clinical and Molecular Features of PO... | |
| 2013 | Scott R Kennedy, Jesse J Salk, Michael W Schmitt, Lawrence A Loeb | Ultra-Sensitive Sequencing Reveals an... | |
| 2012 | MR Bekheirnia, Weiming Zhang, T Eble, A Willis, A Shaibani, Lee-Jun C Wong, F Scaglia, SU Dhar | POLG mutation in a patient with catar... | |
| 2012 | Deborah L Croteau, Marie L Rossi, Chandrika Canugovi, Jane Tian, Peter Sykora, Mahesh Ramamoorthy, Zhengming Wang, Dharmendra Kumar Singh, Mansour Akbari, Rajesh Kasiviswanathan, William C Copeland, Vilhelm A Bohr | RECQL4 localizes to mitochondria and ... | |
| 2012 | Christal D Sohl, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson | Mutations in human DNA polymerase γ c... | |
| 2012 | Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A Bohr, Ulrich Hübscher, Pavel Janscak | Involvement of Werner syndrome protei... | |
| 2011 | Liliya Euro, Gregory A Farnum, Eino J H Palin, Anu Suomalainen, Laurie S Kaguni | Clustering of Alpers disease mutation... | |
| 2011 | Marcos T Oliveira, Laurie S Kaguni | Reduced stimulation of recombinant Po... | |
| 2011 | Rajesh Kasiviswanathan, Margaret A Gustafson, William C Copeland, Joel N Meyer | Human mitochondrial DNA polymerase γ ... | Cloned or native,Tagged,Tag Name,Full length or truncated,3-5' exo,All properties |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2011 | Neli Atanassova, Javier Miralles Fusté, Sjoerd Wanrooij, Bertil Macao, Steffi Goffart, Stefan Bäckström, Geraldine Farge, Ivan Khvorostov, Nils-Göran Larsson, Johannes N Spelbrink, Maria Falkenberg | Sequence-specific stalling of DNA pol... | |
| 2010 | Eino J H Palin, Annamari Lesonen, Carol L Farr, Liliya Euro, Anu Suomalainen, Laurie S Kaguni | Functional analysis of H. sapiens DNA... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2009 | Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structure and activity relationship o... | |
| 2009 | Young-Sam Lee, W Dexter Kennedy, Y Whitney Yin | Structural insight into processive hu... | Cloned or native,Tagged,Tag Name,Full length or truncated,Polymerase Catalytic Residue Amino Acids,All properties |
| 2009 | Christopher M Bailey, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson | R964C mutation of DNA polymerase gamm... | |
| 2008 | Scott D McCulloch, Thomas A Kunkel | The fidelity of DNA synthesis by euka... | 3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties |
| 2008 | Jason D Fowler, Jessica A Brown, Kenneth A Johnson, Zucai Suo | Kinetic investigation of the inhibito... | |
| 2008 | Patrick P Lestienne, François Boudsocq, Jacques E Bonnet | Initiation of DNA replication by a th... | |
| 2008 | Bartosz Szczesny, Anne W Tann, Matthew J Longley, William C Copeland, Sankar Mitra | Long patch base excision repair in ma... | |
| 2008 | Harold R Lee, Sandra A Helquist, Eric T Kool, Kenneth A Johnson | Importance of hydrogen bonding for ef... | |
| 2007 | Harold R Lee, Kenneth A Johnson | Fidelity and processivity of reverse ... | |
| 2007 | Hikaru Yamanaka, Hiroyuki Gatanaga, Pope Kosalaraksa, Saori Matsuoka-Aizawa, Tomonori Takahashi, Seisuke Kimura, Shinichi Oka | Novel mutation of human DNA polymeras... | |
| 2007 | Elena Yakubovskaya, Mark Lukin, Zhixin Chen, John Berriman, Joseph S Wall, Ryuji Kobayashi, Caroline Kisker, Daniel F Bogenhagen | The EM structure of human DNA polymer... | |
| 2007 | Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya | Activity against human immunodeficien... | |
| 2006 | Li Fan, Sangbumn Kim, Carol L Farr, Kevin T Schaefer, Kathleen M Randolph, John A Tainer, Laurie S Kaguni | A novel processive mechanism for DNA ... | Processivity,3-5' exo,Kd,All properties |
| 2006 | Katarzyna Stopińska, Tomasz Grzybowski, Boris A Malyarchuk, Miroslava V Derenko, Danuta Miścicka-Sliwka | Optimization of the Y831C mutation de... | |
| 2006 | Yuko Yonezawa, Isoko Kuriyama, Atsushi Fukuoh, Tsuyoshi Muta, Dongchon Kang, Masaharu Takemura, Ikunoshin Kato, Hiromi Yoshida, Yoshiyuki Mizushina | Inhibitory effect of coenzyme Q on eu... | |
| 2005 | Sherine S L Chan, Matthew J Longley, William C Copeland | The common A467T mutation in the huma... | |
| 2005 | Matthew J Longley, Maria A Graziewicz, Rachelle J Bienstock, William C Copeland | Consequences of mutations in human DN... | |
| 2004 | Eisuke Murakami, Adrian S Ray, Raymond F Schinazi, Karen S Anderson | Investigating the effects of stereoch... | |
| 2004 | Maria A Graziewicz, Jane M Sayer, Donald M Jerina, William C Copeland | Nucleotide incorporation by human DNA... | |
| 2004 | Kevin A Fiala, Zucai Suo | Pre-steady-state kinetic studies of t... | Overall Error Rate,All properties |
| 2003 | Eisuke Murakami, Joy Y Feng, Harold R Lee, Jeremiah Hanes, Kenneth A Johnson, Karen S Anderson | Characterization of novel reverse tra... | |
| 2003 | Susan E Lim, Mikhail V Ponamarev, Matthew J Longley, William C Copeland | Structural determinants in human DNA ... | |
| 2002 | Christophe Rocher, Thierry Letellier, William C Copeland, Patrick Lestienne | Base composition at mtDNA boundaries ... | |
| 2002 | Vineeta Khare, Kristin A Eckert | The proofreading 3'-->5' exonuclease ... | 3-5' exo,5-3' exo,All properties |
| 2001 | Susan E Lim, William C Copeland | Differential incorporation and remova... | |
| 2001 | Matthew J Longley, Dinh Nguyen, Thomas A Kunkel, William C Copeland | The fidelity of human DNA polymerase ... | Tagged,Tag Name,Full length or truncated,Nucleotide Substitution Rate,Molecular Weight,Nucleotide incorporation accessory protein(s),All properties |
| 2001 | Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter | Mechanism of action of 1-beta-D-2,6-d... | |
| 2001 | Allison A Johnson, Kenneth A Johnson | Fidelity of nucleotide incorporation ... | |
| 2000 | Frank C Richardson, Robert D Kuchta, A Mazurkiewicz, Katherine A Richardson | Polymerization of 2'-fluoro- and 2'-O... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1999 | Susan E Lim, Matthew J Longley, William C Copeland | The mitochondrial p55 accessory subun... | Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,Other accessory protein(s),All properties |
| 1998 | Matthew J Longley, Rajendra Prasad, Deepak K Srivastava, Samuel H Wilson, William C Copeland | Identification of 5'-deoxyribose phos... | |
| 1998 | S W Graves, Allison A Johnson, Kenneth A Johnson | Expression, purification, and initial... | Tagged,Tag Name,Full length or truncated,Processivity,3-5' exo,Kd,kcat,Molecular Weight,Vmax,All properties |
| 1998 | Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland | Characterization of the native and re... | RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties |
| 1998 | Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland | Characterization of the native and re... | RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties |
| 1996 | W Lewis, E S Levine, B Griniuviene, K O Tankersley, J M Colacino, J P Sommadossi, K A Watanabe, Fred W Perrino | Fialuridine and its metabolites inhib... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,All properties |
| 1995 | N M Gray, C L Marr, C R Penn, J M Cameron, R C Bethell | The intracellular phosphorylation of ... | |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1991 | K B Frank, G J Noll, E V Connell, I S Sim | Kinetic interaction of human immunode... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1989 | Thomas A Kunkel, D W Mosbaugh | Exonucleolytic proofreading by a mamm... | 3-5' exo,All properties |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1987 | P Lestienne | Evidence for a direct role of the DNA... | |
| 1979 | P F Pignatti, E Cassai, U Bertazzoni | Herpes simplex virus DNA synthesis in... | |
| 1978 | R Dicioccio, B I Srivastava | Inhibition of deoxyribonucleic acid p... | |
| 1977 | Ulrich Hübscher, C C Kuenzle, Silvio Spadari | Identity of DNA polymerase gamma from... |
Protein sequence:
Predicted Structure Model
Predicted model
AlphaFold DB
Not experimentally determined
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
Pol gamma database record viewAllMutations
Protein information: Uniprot P54098 search for Human Pol gamma at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-P54098-F1