Human Pol gamma

From H. sapiens (aliases:h pol gamma, pol gamma, hsa pol gamma) (genes: POLG)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol gamma.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

NIEHS Pol Gamma Mutation Database: viewAllMutations

Human Pol gamma is a family A enzyme from H. sapiens.

Selected Properties for Human Pol gamma:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (10) No (2) 1.2e-06 errors/bp (1) 1.0e-05-1.0e-05 errors/bp (2) 1.8e-06-2.9e-04 errors/bp (2)
Year Authors Title Results by property
2013 Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida Inhibitory effects of α-mangostin on ...
2013 Rajesh Kasiviswanathan, Irina G Minko, R Stephen Lloyd, William C Copeland Translesion synthesis past acrolein-d...
2013 Jeffrey D Stumpf, Russell P Saneto, William C Copeland Clinical and Molecular Features of PO...
2013 Scott R Kennedy, Jesse J Salk, Michael W Schmitt, Lawrence A Loeb Ultra-Sensitive Sequencing Reveals an...
2012 MR Bekheirnia, Weiming Zhang, T Eble, A Willis, A Shaibani, Lee-Jun C Wong, F Scaglia, SU Dhar POLG mutation in a patient with catar...
2012 Deborah L Croteau, Marie L Rossi, Chandrika Canugovi, Jane Tian, Peter Sykora, Mahesh Ramamoorthy, Zhengming Wang, Dharmendra Kumar Singh, Mansour Akbari, Rajesh Kasiviswanathan, William C Copeland, Vilhelm A Bohr RECQL4 localizes to mitochondria and ...
2012 Christal D Sohl, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson Mutations in human DNA polymerase γ c...
2012 Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A Bohr, Ulrich Hübscher, Pavel Janscak Involvement of Werner syndrome protei...
2011 Liliya Euro, Gregory A Farnum, Eino J H Palin, Anu Suomalainen, Laurie S Kaguni Clustering of Alpers disease mutation...
2011 Marcos T Oliveira, Laurie S Kaguni Reduced stimulation of recombinant Po...
2011 Rajesh Kasiviswanathan, Margaret A Gustafson, William C Copeland, Joel N Meyer Human mitochondrial DNA polymerase γ ... Cloned or native,Tagged,Tag Name,Full length or truncated,3-5' exo,All properties
2011 Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida Effects of quinone derivatives, such ...
2011 Neli Atanassova, Javier Miralles Fusté, Sjoerd Wanrooij, Bertil Macao, Steffi Goffart, Stefan Bäckström, Geraldine Farge, Ivan Khvorostov, Nils-Göran Larsson, Johannes N Spelbrink, Maria Falkenberg Sequence-specific stalling of DNA pol...
2010 Eino J H Palin, Annamari Lesonen, Carol L Farr, Liliya Euro, Anu Suomalainen, Laurie S Kaguni Functional analysis of H. sapiens DNA...
2010 Mark D Sutton Coordinating DNA polymerase traffic d...
2009 Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina Structure and activity relationship o...
2009 Young-Sam Lee, W Dexter Kennedy, Y Whitney Yin Structural insight into processive hu... Cloned or native,Tagged,Tag Name,Full length or truncated,Polymerase Catalytic Residue Amino Acids,All properties
2009 Christopher M Bailey, Rajesh Kasiviswanathan, William C Copeland, Karen S Anderson R964C mutation of DNA polymerase gamm...
2008 Scott D McCulloch, Thomas A Kunkel The fidelity of DNA synthesis by euka... 3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties
2008 Jason D Fowler, Jessica A Brown, Kenneth A Johnson, Zucai Suo Kinetic investigation of the inhibito...
2008 Patrick P Lestienne, François Boudsocq, Jacques E Bonnet Initiation of DNA replication by a th...
2008 Bartosz Szczesny, Anne W Tann, Matthew J Longley, William C Copeland, Sankar Mitra Long patch base excision repair in ma...
2008 Harold R Lee, Sandra A Helquist, Eric T Kool, Kenneth A Johnson Importance of hydrogen bonding for ef...
2007 Harold R Lee, Kenneth A Johnson Fidelity and processivity of reverse ...
2007 Hikaru Yamanaka, Hiroyuki Gatanaga, Pope Kosalaraksa, Saori Matsuoka-Aizawa, Tomonori Takahashi, Seisuke Kimura, Shinichi Oka Novel mutation of human DNA polymeras...
2007 Elena Yakubovskaya, Mark Lukin, Zhixin Chen, John Berriman, Joseph S Wall, Ryuji Kobayashi, Caroline Kisker, Daniel F Bogenhagen The EM structure of human DNA polymer...
2007 Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya Activity against human immunodeficien...
2006 Li Fan, Sangbumn Kim, Carol L Farr, Kevin T Schaefer, Kathleen M Randolph, John A Tainer, Laurie S Kaguni A novel processive mechanism for DNA ... Processivity,3-5' exo,Kd,All properties
2006 Katarzyna Stopińska, Tomasz Grzybowski, Boris A Malyarchuk, Miroslava V Derenko, Danuta Miścicka-Sliwka Optimization of the Y831C mutation de...
2006 Yuko Yonezawa, Isoko Kuriyama, Atsushi Fukuoh, Tsuyoshi Muta, Dongchon Kang, Masaharu Takemura, Ikunoshin Kato, Hiromi Yoshida, Yoshiyuki Mizushina Inhibitory effect of coenzyme Q on eu...
2005 Sherine S L Chan, Matthew J Longley, William C Copeland The common A467T mutation in the huma...
2005 Matthew J Longley, Maria A Graziewicz, Rachelle J Bienstock, William C Copeland Consequences of mutations in human DN...
2004 Eisuke Murakami, Adrian S Ray, Raymond F Schinazi, Karen S Anderson Investigating the effects of stereoch...
2004 Maria A Graziewicz, Jane M Sayer, Donald M Jerina, William C Copeland Nucleotide incorporation by human DNA...
2004 Kevin A Fiala, Zucai Suo Pre-steady-state kinetic studies of t... Overall Error Rate,All properties
2003 Eisuke Murakami, Joy Y Feng, Harold R Lee, Jeremiah Hanes, Kenneth A Johnson, Karen S Anderson Characterization of novel reverse tra...
2003 Susan E Lim, Mikhail V Ponamarev, Matthew J Longley, William C Copeland Structural determinants in human DNA ...
2002 Christophe Rocher, Thierry Letellier, William C Copeland, Patrick Lestienne Base composition at mtDNA boundaries ...
2002 Vineeta Khare, Kristin A Eckert The proofreading 3'-->5' exonuclease ... 3-5' exo,5-3' exo,All properties
2001 Susan E Lim, William C Copeland Differential incorporation and remova...
2001 Matthew J Longley, Dinh Nguyen, Thomas A Kunkel, William C Copeland The fidelity of human DNA polymerase ... Tagged,Tag Name,Full length or truncated,Nucleotide Substitution Rate,Molecular Weight,Nucleotide incorporation accessory protein(s),All properties
2001 Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter Mechanism of action of 1-beta-D-2,6-d...
2001 Allison A Johnson, Kenneth A Johnson Fidelity of nucleotide incorporation ...
2000 Frank C Richardson, Robert D Kuchta, A Mazurkiewicz, Katherine A Richardson Polymerization of 2'-fluoro- and 2'-O...
1999 J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando Anti-human immunodeficiency virus typ...
1999 Susan E Lim, Matthew J Longley, William C Copeland The mitochondrial p55 accessory subun... Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,Other accessory protein(s),All properties
1998 Matthew J Longley, Rajendra Prasad, Deepak K Srivastava, Samuel H Wilson, William C Copeland Identification of 5'-deoxyribose phos...
1998 S W Graves, Allison A Johnson, Kenneth A Johnson Expression, purification, and initial... Tagged,Tag Name,Full length or truncated,Processivity,3-5' exo,Kd,kcat,Molecular Weight,Vmax,All properties
1998 Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland Characterization of the native and re... RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties
1998 Matthew J Longley, P A Ropp, Susan E Lim, William C Copeland Characterization of the native and re... RT,Cloned or native,Full length or truncated,Processivity,3-5' exo,Molecular Weight,All properties
1996 W Lewis, E S Levine, B Griniuviene, K O Tankersley, J M Colacino, J P Sommadossi, K A Watanabe, Fred W Perrino Fialuridine and its metabolites inhib...
1996 F B Perler, Sandeep Kumar, H Kong Thermostable DNA polymerases. Full length or truncated,3-5' exo,5-3' exo,All properties
1995 N M Gray, C L Marr, C R Penn, J M Cameron, R C Bethell The intracellular phosphorylation of ...
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Stereospecificity of human DNA polyme...
1991 K B Frank, G J Noll, E V Connell, I S Sim Kinetic interaction of human immunode...
1990 Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari Revised nomenclature for eukaryotic D...
1989 Thomas A Kunkel, D W Mosbaugh Exonucleolytic proofreading by a mamm... 3-5' exo,All properties
1988 H Nakane, Jan Balzarini, Erik De Clercq, K Ono Differential inhibition of various de...
1987 P Lestienne Evidence for a direct role of the DNA...
1979 P F Pignatti, E Cassai, U Bertazzoni Herpes simplex virus DNA synthesis in...
1978 R Dicioccio, B I Srivastava Inhibition of deoxyribonucleic acid p...
1977 Ulrich Hübscher, C C Kuenzle, Silvio Spadari Identity of DNA polymerase gamma from...
Protein sequence:
DNA sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Human Pol gamma R3P
Human Pol gamma G11D
Human Pol gamma P18S
Human Pol gamma R42X
Human Pol gamma Q43R
Human Pol gamma Q44X
Human Pol gamma Q45R
Human Pol gamma Q49X
Human Pol gamma Q49E
Human Pol gamma Q50X
Human Pol gamma Q53X
Human Pol gamma S64L
Human Pol gamma Q68X
Human Pol gamma L83P
Human Pol gamma H110Y
Human Pol gamma W113G
Human Pol gamma D136E
Human Pol gamma A143V
Human Pol gamma E183X
Human Pol gamma R193Q
Human Pol gamma D198AG200A No (1)
Human Pol gamma N198A,Q200A
Human Pol gamma C224Y
Human Pol gamma R227W
Human Pol gamma R227P
Human Pol gamma R232G
Human Pol gamma R232H
Human Pol gamma W235X
Human Pol gamma Q238R
Human Pol gamma P241L
Human Pol gamma L244P
Human Pol gamma T251I
Human Pol gamma G268A
Human Pol gamma R275X
Human Pol gamma H277L
Human Pol gamma L304R
Human Pol gamma S305R
Human Pol gamma Q308H
Human Pol gamma R309L
Human Pol gamma R309H
Human Pol gamma W312R
Human Pol gamma P324S
Human Pol gamma S332X
Human Pol gamma R374X
Human Pol gamma G380D
Human Pol gamma L392V
Human Pol gamma R417T
Human Pol gamma C418R
Human Pol gamma G426S
Human Pol gamma L428P
Human Pol gamma M430L
Human Pol gamma G431V
Human Pol gamma S433C
Human Pol gamma T452X
Human Pol gamma L463F
Human Pol gamma A467T
Human Pol gamma N468D
Human Pol gamma Y479X
Human Pol gamma Q497H
Human Pol gamma S511N
Human Pol gamma G517V
Human Pol gamma R546G
Human Pol gamma R546C
Human Pol gamma R546S
Human Pol gamma K561M
Human Pol gamma R562Q
Human Pol gamma H569Q
Human Pol gamma R574W
Human Pol gamma R579W
Human Pol gamma P587L
Human Pol gamma P589L
Human Pol gamma R597W
Human Pol gamma M603L
Human Pol gamma L605R
Human Pol gamma Y614X
Human Pol gamma R617C
Human Pol gamma L623W
Human Pol gamma R627Q
Human Pol gamma R627W
Human Pol gamma R628Q
Human Pol gamma P648R
Human Pol gamma H659Q
Human Pol gamma E662K
Human Pol gamma Q666L
Human Pol gamma R709X
Human Pol gamma Q715X
Human Pol gamma R722H
Human Pol gamma H734R
Human Pol gamma G737R
Human Pol gamma N740D
Human Pol gamma G746S
Human Pol gamma W748S
Human Pol gamma F749S
Human Pol gamma L752P
Human Pol gamma K755E
Human Pol gamma G763R
Human Pol gamma A767D
Human Pol gamma A804T
Human Pol gamma R807P
Human Pol gamma R807C
Human Pol gamma Y831C
Human Pol gamma Y831F
Human Pol gamma Y831S
Human Pol gamma G848S
Human Pol gamma T849H
Human Pol gamma T851A
Human Pol gamma R852C
Human Pol gamma R853Q
Human Pol gamma R853W
Human Pol gamma V855A
Human Pol gamma A862T
Human Pol gamma N864S
Human Pol gamma R869Q
Human Pol gamma E873X
Human Pol gamma Q879H
Human Pol gamma T885S
Human Pol gamma L886P
Human Pol gamma G888S
Human Pol gamma A889T
Human Pol gamma E895G
Human Pol gamma T914P
Human Pol gamma W918R
Human Pol gamma G923D
Human Pol gamma G923R
Human Pol gamma D930N
Human Pol gamma H932Y
Human Pol gamma R943C
Human Pol gamma R943H
Human Pol gamma R953C
Human Pol gamma Y955C
Human Pol gamma A957S
Human Pol gamma A957P
Human Pol gamma F961S
pol gamma R964C
Human Pol gamma R964C
Human Pol gamma L965X
Human Pol gamma L966R
Human Pol gamma S998W
Human Pol gamma W1020X
Human Pol gamma R1047W
Human Pol gamma R1047Q
Human Pol gamma G1051R
Human Pol gamma P1073L
Human Pol gamma G1076V
Human Pol gamma I1079L
Human Pol gamma F1092L
Human Pol gamma S1095R
Human Pol gamma R1096C
Human Pol gamma R1096H
Human Pol gamma S1104C
Human Pol gamma A1105T
Human Pol gamma V1106I
Human Pol gamma H1110Y
Human Pol gamma R1128H
Human Pol gamma H1134R
Human Pol gamma E1136K
Human Pol gamma R1138C
Human Pol gamma R1142W
Human Pol gamma E1143G
Human Pol gamma R1146C
Human Pol gamma M1163R
Human Pol gamma F1164I
Human Pol gamma F1164L
Human Pol gamma L1173fsX
Human Pol gamma S1176L
Human Pol gamma D1184N
Human Pol gamma R1187W
Human Pol gamma K1191R
Human Pol gamma K1191N
Human Pol gamma D1196N
Human Pol gamma T1199X
Human Pol gamma G1205A
Human Pol gamma S1230F
Human Pol gamma Q1236H
Human pol gamma (exo-) 4.5e-05 errors/bp (1) 6.2e-03 errors/bp (1)

Using Polbase tables:

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