New class of HIV integrase inhibitors that block viral replication in cell culture.

Pannecouque C, Pluymers W, Van Maele B, Tetz V, Cherepanov P, De Clercq E, Witvrouw M, Debyser Z
Current biology : CB (2002), Volume 12, Page 1169
PubMed entry

Abstract:

To improve the existing combination therapies of infection with the ...
To improve the existing combination therapies of infection with the human immunodeficiency virus (HIV) and to cope with virus strains that are resistant to multiple drugs, we initiated a search for effective inhibitors of HIV integrase, the enzyme responsible for inserting the viral cDNA into the host cell chromosome.

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HIV RT

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