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Spadari S

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Publications:

Title Authors Year Journal
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Spadari S Nucleosides & nucleotides
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells. Spadari S Anticancer research
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Spadari S 2008 Biochemical pharmacology
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate. Spadari S 2007 Angewandte Chemie (International ed. in English)
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. Spadari S 2007 Nucleic acids research
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants. Spadari S 2007 ChemMedChem
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Spadari S 2006 Nucleic acids research
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Spadari S 2005 Nucleic acids research
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. Spadari S 2005 Journal of medicinal chemistry
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Spadari S 2005 Antimicrobial agents and chemotherapy
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Spadari S 2005 Molecular pharmacology
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Spadari S 2005 The Journal of biological chemistry
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. Spadari S 2004 FASEB J
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Spadari S 2004 Biochemistry
HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. Spadari S 2004 Current drug metabolism
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. Spadari S 2004 The Biochemical journal
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Spadari S 2004 Antimicrobial agents and chemotherapy
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. Spadari S 2004 Antimicrobial agents and chemotherapy
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Spadari S 2003 Biochemistry
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Spadari S 2003 The Journal of biological chemistry
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Spadari S 2003 Nucleic acids research
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. Spadari S 2003 The Journal of biological chemistry
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Spadari S 2002 The Journal of biological chemistry
Combinations against combinations: associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations. Spadari S 2002 Current drug metabolism
DNA polymerase theta purified from human cells is a high-fidelity enzyme. Spadari S 2002 Journal of molecular biology
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. Spadari S 2002 The EMBO journal
Eukaryotic DNA polymerases. Spadari S 2002 Annual review of biochemistry
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Spadari S 2001 Proceedings of the National Academy of Sciences of the United States of America
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Spadari S 2001 The Journal of biological chemistry
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. Spadari S 2001 Journal of medicinal chemistry
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Spadari S 2001 Antimicrobial agents and chemotherapy
Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Spadari S 2001 The Journal of biological chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents. Spadari S 2000 Antiviral chemistry & chemotherapy
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. Spadari S 2000 Antimicrobial agents and chemotherapy
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes. Spadari S 2000 The Biochemical journal
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Spadari S 2000 Journal of molecular biology
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Spadari S 1999 Nucleic acids research
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. Spadari S 1999 Journal of medicinal chemistry
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Spadari S 1999 Journal of molecular biology
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides. Spadari S 1998 Expert opinion on investigational drugs
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Spadari S 1997 Journal of molecular biology
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides. Spadari S 1995 Biochimie
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. Spadari S 1995 Nucleic acids research
Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. Spadari S 1994 In Vivo
Developmental activity profile of DNA polymerases delta and alpha in rat neurons suggests a coordinated in vivo function. Spadari S 1992 In vivo (Athens, Greece)
HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H. Spadari S 1991 Nucleic acids research
Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity. Spadari S 1991 Nucleic acids research
Revised nomenclature for eukaryotic DNA polymerases. Spadari S 1990 Eur J Biochem
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development. Spadari S 1990 Mutation research
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease. Spadari S 1990 FEBS letters
Calf thymus DNA polymerase delta independent of proliferating cell nuclear antigen (PCNA). Spadari S 1989 Nucleic acids research
Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta. Spadari S 1988 Biochimica et biophysica acta
Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases? Spadari S 1988 FEBS letters
Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen. Spadari S 1988 Nucleic acids research
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus. Spadari S 1987 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha. Spadari S 1987 Nucleic acids research
Differential incorporation of thymidylate analogues into DNA by DNA polymerase alpha and by DNA polymerases specified by two herpes simplex viruses. Spadari S 1982 The Journal of general virology
An autoradiographic demonstration of nuclear DNA replication by DNA polymerase alpha and of mitochondrial DNA synthesis by DNA polymerase gamma. Spadari S 1981 Nucleic acids research
Functional roles of the plant alpha-like and gamma-like DNA polymerases. Spadari S 1981 FEBS letters
Aphidicolin does not inhibit DNA repair synthesis in ultraviolet-irradiated HeLa cells. A radioautographic study. Spadari S 1981 The Biochemical journal
DNA polymerase gamma, cytochrome c oxidase and mitochondrial integrity in rabbit spleen lymphocytes stimulated with concanavalin A. Spadari S 1980 Exp Cell Res
Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes. Spadari S 1980 Journal of virology
A gamma-like DNA polymerase in spinach chloroplasts. Spadari S 1980 European journal of biochemistry / FEBS
Specific and reversible inhibition by aphidicolin in the alpha-like DNA polymerase of plant cells. Spadari S 1980 FEBS letters
Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin. Spadari S 1980 Nucleic acids research
Enhancement of the rate of DNA polymerase-alpha activity on duplex DNA by a DNA-binding protein and a DNA-dependent ATPase of mammalian cells. Spadari S 1979 Cold Spring Harbor symposia on quantitative biology
Functional roles of DNA polymerases beta and gamma. Spadari S 1979 Proceedings of the National Academy of Sciences of the United States of America
Functions of DNA polymerases alpha, beta, and gamma in neurons during development. Spadari S 1979 Cold Spring Harbor symposia on quantitative biology
DNA polymerase beta from brain neurons is a repair enzyme. Spadari S 1979 European journal of biochemistry / FEBS
Effect of aphidicolin on viral and human DNA polymerases. Spadari S 1979 Biochemical and biophysical research communications
DNA polymerase alpha, beta and gamma activities in rabbit spleen cell populations stimulated by various doses of concanavalin A. Spadari S 1978 Exp Cell Res
Variation of DNA polymerases-alpha, -beta. and -gamma during perinatal tissue growth and differentiation. Spadari S 1977 Nucleic acids research
Identity of DNA polymerase gamma from synaptosomal mitochondria and rat-brain nuclei. Spadari S 1977 European journal of biochemistry / FEBS
Variations of DNA polymerase-alpha and -beta during prolonged stimulation of human lymphocytes. Spadari S 1976 Proceedings of the National Academy of Sciences of the United States of America
RNA-primed DNA synthesis: specific catalysis by HeLa cell DNA polymerase alpha. Spadari S 1975 Proceedings of the National Academy of Sciences of the United States of America
The interrelation between DNA synthesis and various DNA polymerase activities in synchronized HeLa cells. Spadari S 1974 Journal of molecular biology
HeLa cell R-deoxyribonucleic acid polymerases. Separation and characterization of two enzymatic activities. Spadari S 1974 The Journal of biological chemistry
The dissimilitude of the low and high molecular weight deoxyribonucleic acid-dependent deoxyribonucleic acid polymerases of HeLa cells. Spadari S 1974 The Journal of biological chemistry
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