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Coen DM

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Publications:

Title Authors Year Journal
Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. Coen DM 2012 mBio
A Mutation Deleting Sequences Encoding the Amino Terminus of human Cytomegalovirus UL84 impairs Interaction with UL44 and Capsid Localization. Coen DM 2012 Journal of virology
Human Cytomegalovirus UL44 Concentrates at the Periphery of Replication Compartments, the Site of Viral DNA Synthesis. Coen DM 2011 Journal of virology
Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Coen DM 2011 Virology
Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. Coen DM 2010 The Journal of general virology
The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. Coen DM 2010 Journal of virology
Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44. Coen DM 2010 The Journal of general virology
Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. Coen DM 2010 Journal of virology
Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. Coen DM 2009 J Virol
The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. Coen DM 2009 J Virol
The human cytomegalovirus UL44 C clamp wraps around DNA. Coen DM 2008 Structure (London, England : 1993)
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. Coen DM 2008 Journal of virology
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Coen DM 2008 Proceedings of the National Academy of Sciences of the United States of America
The positively charged surface of herpes simplex virus UL42 mediates DNA binding. Coen DM 2008 The Journal of biological chemistry
Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript. Coen DM 2008 Journal of virology
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. Coen DM 2007 Journal of virology
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. Coen DM 2007 J Virol
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Coen DM 2007 Nucleic acids research
Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Coen DM 2006 Chemistry & biology
Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. Coen DM 2006 The Journal of biological chemistry
Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. Coen DM 2005 Journal of virology
Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. Coen DM 2004 J Virol
Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. Coen DM 2004 J Virol
Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication. Coen DM 2004 Chemistry & biology
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Coen DM 2004 Molecular cell
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. Coen DM 2004 Journal of molecular biology
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Coen DM 2004 Virology journal
Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches. Coen DM 2001 J Virol
Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor. Coen DM 2001 Molecular cell
Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase. Coen DM 2000 The Journal of biological chemistry
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Coen DM 2000 Molecular cell
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Coen DM 1999 Proceedings of the National Academy of Sciences of the United States of America
Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate. Coen DM 1999 Journal of virology
ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. Coen DM 1998 J Virol
Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. Coen DM 1998 Antiviral research
A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Coen DM 1998 Virology
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. Coen DM 1997 J Virol
Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42. Coen DM 1995 Journal of virology
Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype. Coen DM 1995 Methods in enzymology
Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface. Coen DM 1995 Proceedings of the National Academy of Sciences of the United States of America
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase. Coen DM 1995 Virology
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. Coen DM 1994 The Journal of biological chemistry
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. Coen DM 1993 Journal of virology
Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Coen DM 1993 Proceedings of the National Academy of Sciences of the United States of America
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Coen DM 1993 Antimicrob Agents Chemother
Unusual regulation of expression of the herpes simplex virus DNA polymerase gene. Coen DM 1993 J Virol
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication. Coen DM 1993 J Virol
Functional analysis of the herpes simplex virus UL42 protein. Coen DM 1993 Journal of virology
Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet. Coen DM 1992 Advances in experimental medicine and biology
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. Coen DM 1992 Journal of virology
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs. Coen DM 1991 The Journal of infectious diseases
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. Coen DM 1991 J Virol
Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. Coen DM 1991 Molecular and cellular biology
The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy. Coen DM 1991 Antiviral research
A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein. Coen DM 1990 The Journal of biological chemistry
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. Coen DM 1990 Journal of virology
Translational regulation of herpes simplex virus DNA polymerase. Coen DM 1990 J Virol
The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. Coen DM 1990 J Virol
Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition. Coen DM 1990 J Virol
Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Coen DM 1990 Nucleic acids research
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Coen DM 1989 Annals of internal medicine
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. Coen DM 1988 Journal of virology
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Coen DM 1988 Proceedings of the National Academy of Sciences of the United States of America
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine. Coen DM 1986 Antimicrob Agents Chemother
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene. Coen DM 1986 Journal of virology
Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1. Coen DM 1986 DNA (Mary Ann Liebert, Inc.)
Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Coen DM 1985 Virology
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. Coen DM 1985 Journal of virology
Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Coen DM 1985 Proceedings of the National Academy of Sciences of the United States of America
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Coen DM 1984 Virology
Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus. Coen DM 1984 Journal of virology
Genetics of herpes simplex virus. Coen DM 1984 The Journal of investigative dermatology
Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin. Coen DM 1984 Antimicrobial agents and chemotherapy
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. Coen DM 1983 Nucleic acids research
Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment. Coen DM 1983 Virology
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine. Coen DM 1982 Journal of virology
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities. Coen DM 1981 J Virol
Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. Coen DM 1980 Proceedings of the National Academy of Sciences of the United States of America

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