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Guengerich FP

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Publications:

Title Authors Year Journal
Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. Guengerich FP 2014 The Journal of biological chemistry
Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Guengerich FP 2013 Biochemistry
Incorporation of Nucleoside Probes Opposite O(6) -Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding. Guengerich FP 2013 Chembiochem : a European journal of chemical biology
Effects of N2-Alkylguanine, O6-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-family DNA Polymerase Vent (exo-). Guengerich FP 2012 Chemical research in toxicology
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine. Guengerich FP 2011 Chemical research in toxicology
Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. Guengerich FP 2011 Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
Roles of the Four DNA Polymerases of the Crenarchaeon Sulfolobus solfataricus and Accessory Proteins in DNA Replication. Guengerich FP 2011 The Journal of biological chemistry
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Guengerich FP 2010 Acta Crystallogr Sect F Struct Biol Cryst Commun
Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Guengerich FP 2010 Journal of molecular biology
Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Guengerich FP 2010 Angewandte Chemie (International ed. in English)
The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Guengerich FP 2010 Chemical research in toxicology
Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion. Guengerich FP 2010 Biochemistry
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Guengerich FP 2010 Chemical research in toxicology
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. Guengerich FP 2010 The Journal of biological chemistry
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. Guengerich FP 2009 The Journal of biological chemistry
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Guengerich FP 2009 Journal of molecular biology
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Guengerich FP 2009 Chemical research in toxicology
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. Guengerich FP 2009 The Journal of biological chemistry
Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Guengerich FP 2009 The Journal of biological chemistry
Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. Guengerich FP 2009 The Journal of biological chemistry
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Guengerich FP 2009 Biochemistry
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Guengerich FP 2009 The Journal of biological chemistry
Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Guengerich FP 2009 Journal of molecular biology
Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one . Guengerich FP 2009 Biochemistry
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. Guengerich FP 2009 The Journal of biological chemistry
Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. Guengerich FP 2008 The Journal of biological chemistry
Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. Guengerich FP 2008 The Journal of biological chemistry
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. Guengerich FP 2007 The Journal of biological chemistry
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. Guengerich FP 2007 The Journal of biological chemistry
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. Guengerich FP 2007 The Journal of biological chemistry
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. Guengerich FP 2007 The Journal of biological chemistry
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. Guengerich FP 2006 The Journal of biological chemistry
Interactions of carcinogen-bound DNA with individual DNA polymerases. Guengerich FP 2006 Chem Rev
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Guengerich FP 2006 Biochemistry
Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. Guengerich FP 2006 Chemical research in toxicology
Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Guengerich FP 2006 Chemical research in toxicology
Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. Guengerich FP 2006 The Journal of biological chemistry
Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. Guengerich FP 2006 The Journal of biological chemistry
Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. Guengerich FP 2006 The Journal of biological chemistry
Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota. Guengerich FP 2006 The Journal of biological chemistry
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct. Guengerich FP 2005 Biochemistry
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. Guengerich FP 2005 Chemical research in toxicology
Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. Guengerich FP 2005 Chemical research in toxicology
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. Guengerich FP 2005 The Journal of biological chemistry
Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. Guengerich FP 2005 The Journal of biological chemistry
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. Guengerich FP 2005 Journal of molecular biology
Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase. Guengerich FP 2004 The Journal of biological chemistry
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Guengerich FP 2002 Biochemistry
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Guengerich FP 2002 Biochemistry
Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis. Guengerich FP 2001 The Journal of biological chemistry
Kinetic analysis of nucleotide incorporation by mammalian DNA polymerase delta. Guengerich FP 2000 The Journal of biological chemistry
Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. Guengerich FP 1999 Biochemistry
Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione. Guengerich FP 1998 Chemical research in toxicology
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Guengerich FP 1998 Biochemistry
Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. Guengerich FP 1998 Biochemistry
Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Guengerich FP 1997 Biochemistry
Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta. Guengerich FP 1997 Biochemistry

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