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Prakash L

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Publications:

Title Authors Year Journal
The Architecture of Yeast DNA Polymerase ζ Prakash L 2013 Cell reports
An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε Prakash L 2013 Journal of molecular biology
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ Prakash L 2012 Proceedings of the National Academy of Sciences of the United States of America
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Prakash L 2012 Nature structural & molecular biology
DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase. Prakash L 2011 Journal of molecular biology
Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis. Prakash L 2011 Journal of molecular biology
PCNA binding domains in all three subunits of yeast DNA polymerase {delta} modulate its function in DNA replication. Prakash L 2011 Proceedings of the National Academy of Sciences of the United States of America
Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer. Prakash L 2011 Journal of molecular biology
A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase η. Prakash L 2011 Molecular bioSystems
Structural basis for the suppression of skin cancers by DNA polymerase eta. Prakash L 2010 Nature
Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells. Prakash L 2010 Proceedings of the National Academy of Sciences of the United States of America
Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cells. Prakash L 2010 Genes Dev
DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells. Prakash L 2010 Proceedings of the National Academy of Sciences of the United States of America
Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Prakash L 2010 Structure (London, England : 1993)
Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells. Prakash L 2009 Proceedings of the National Academy of Sciences of the United States of America
Replication across template T/U by human DNA polymerase-iota. Prakash L 2009 Structure (London, England : 1993)
Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta. Prakash L 2009 Proceedings of the National Academy of Sciences of the United States of America
Structural insights into yeast DNA polymerase delta by small angle X-ray scattering. Prakash L 2009 Journal of molecular biology
Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta. Prakash L 2009 Nature structural & molecular biology
Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. Prakash L 2009 PloS one
Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast. Prakash L 2009 Genes & development
DNA synthesis across an abasic lesion by human DNA polymerase iota. Prakash L 2009 Structure (London, England : 1993)
Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Prakash L 2008 Structure (London, England : 1993)
Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Prakash L 2008 Proceedings of the National Academy of Sciences of the United States of America
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Prakash L 2008 Proceedings of the National Academy of Sciences of the United States of America
Requirement of Rad5 for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiae. Prakash L 2008 Genetics
Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Prakash L 2007 Molecular cell
Complex formation of yeast Rev1 with DNA polymerase eta. Prakash L 2007 Molecular and cellular biology
Mutations in the ubiquitin binding UBZ motif of DNA polymerase eta do not impair its function in translesion synthesis during replication. Prakash L 2007 Molecular and cellular biology
Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini. Prakash L 2006 Proceedings of the National Academy of Sciences of the United States of America
Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions. Prakash L 2006 Molecular and cellular biology
Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization. Prakash L 2006 Methods in enzymology
Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Prakash L 2006 Proceedings of the National Academy of Sciences of the United States of America
Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases iota and kappa. Prakash L 2006 Molecular and cellular biology
Role of hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase iota. Prakash L 2006 Molecular and cellular biology
Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Prakash L 2006 Nature structural & molecular biology
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Prakash L 2006 Structure (London, England : 1993)
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Prakash L 2005 Annu Rev Biochem
Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA. Prakash L 2005 Molecular and cellular biology
Rev1 employs a novel mechanism of DNA synthesis using a protein template. Prakash L 2005 Science (New York, N.Y.)
A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis. Prakash L 2005 Molecular and cellular biology
Distinct mechanisms of cis-syn thymine dimer bypass by Dpo4 and DNA polymerase eta. Prakash L 2005 Proceedings of the National Academy of Sciences of the United States of America
Trf4 and Trf5 proteins of Saccharomyces cerevisiae exhibit poly(A) RNA polymerase activity but no DNA polymerase activity. Prakash L 2005 Molecular and cellular biology
Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Prakash L 2005 Structure (London, England : 1993)
Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Prakash L 2005 Molecular and cellular biology
Biochemical evidence for the requirement of Hoogsteen base pairing for replication by human DNA polymerase iota. Prakash L 2005 Proceedings of the National Academy of Sciences of the United States of America
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Prakash L 2005 Molecular and cellular biology
Dpo4 is hindered in extending a G.T mismatch by a reverse wobble. Prakash L 2004 Nature structural & molecular biology
Crystal structure of the catalytic core of human DNA polymerase kappa. Prakash L 2004 Structure (London, England : 1993)
Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Prakash L 2004 Molecular and cellular biology
Human DNA polymerase iota utilizes different nucleotide incorporation mechanisms dependent upon the template base. Prakash L 2004 Molecular and cellular biology
Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Prakash L 2004 Molecular and cellular biology
Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Prakash L 2004 Nature
Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. Prakash L 2003 Genes Dev
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol. Prakash L 2003 Genes & development
Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta. Prakash L 2003 The Journal of biological chemistry
Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate. Prakash L 2003 Proceedings of the National Academy of Sciences of the United States of America
The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme. Prakash L 2003 Molecular and cellular biology
Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases. Prakash L 2003 Molecular and cellular biology
Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanine. Prakash L 2003 Molecular and cellular biology
Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta. Prakash L 2003 Proceedings of the National Academy of Sciences of the United States of America
Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Prakash L 2003 Molecular and cellular biology
Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Prakash L 2002 Molecular and cellular biology
Yeast Rev1 protein is a G template-specific DNA polymerase. Prakash L 2002 The Journal of biological chemistry
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. Prakash L 2002 Proceedings of the National Academy of Sciences of the United States of America
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Prakash L 2002 Molecular and cellular biology
Role of human DNA polymerase kappa as an extender in translesion synthesis. Prakash L 2002 Proceedings of the National Academy of Sciences of the United States of America
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts. Prakash L 2001 Molecular and cellular biology
Inefficient bypass of an abasic site by DNA polymerase eta. Prakash L 2001 The Journal of biological chemistry
Acidic residues critical for the activity and biological function of yeast DNA polymerase eta. Prakash L 2001 Molecular and cellular biology
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Prakash L 2001 Molecular cell
Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation. Prakash L 2001 Cell
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Prakash L 2001 Genes Dev
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Prakash L 2001 Proceedings of the National Academy of Sciences of the United States of America
Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct. Prakash L 2001 Molecular and cellular biology
Physical and functional interactions of human DNA polymerase eta with PCNA. Prakash L 2001 Molecular and cellular biology
Accuracy of lesion bypass by yeast and human DNA polymerase eta. Prakash L 2001 Proceedings of the National Academy of Sciences of the United States of America
Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites. Prakash L 2001 The Journal of biological chemistry
Eukaryotic DNA polymerases: proposal for a revised nomenclature. Prakash L 2001 The Journal of biological chemistry
Fidelity and damage bypass ability of Schizosaccharomyces pombe Eso1 protein, comprised of DNA polymerase eta and sister chromatid cohesion protein Ctf7. Prakash L 2001 The Journal of biological chemistry
Interaction with PCNA is essential for yeast DNA polymerase eta function. Prakash L 2001 Molecular cell
Mismatch extension ability of yeast and human DNA polymerase eta. Prakash L 2001 The Journal of biological chemistry
Replication past O(6)-methylguanine by yeast and human DNA polymerase eta. Prakash L 2000 Molecular and cellular biology
Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta. Prakash L 2000 Proceedings of the National Academy of Sciences of the United States of America
Fidelity of human DNA polymerase eta. Prakash L 2000 The Journal of biological chemistry
The human DINB1 gene encodes the DNA polymerase Poltheta. Prakash L 2000 Proceedings of the National Academy of Sciences of the United States of America
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Prakash L 2000 Nat Genet
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Prakash L 2000 Nature
Role of yeast and human DNA polymerase eta in error-free replication of damaged DNA. Prakash L 2000 Cold Spring Harbor symposia on quantitative biology
hRAD30 mutations in the variant form of xeroderma pigmentosum. Prakash L 1999 Science (New York, N.Y.)
Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA. Prakash L 1999 Proceedings of the National Academy of Sciences of the United States of America
Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta. Prakash L 1999 The Journal of biological chemistry
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Prakash L 1999 Science
Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function. Prakash L 1999 The Journal of biological chemistry
Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Prakash L 1998 Genes & development
Requirement of yeast DNA polymerase delta in post-replicational repair of UV-damaged DNA. Prakash L 1997 The Journal of biological chemistry
Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair. Prakash L 1996 Proceedings of the National Academy of Sciences of the United States of America
DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II. Prakash L 1994 Nature
RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcription. Prakash L 1994 Nature
Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme. Prakash L 1993 Nucleic acids research
Decreased UV mutagenesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae. Prakash L 1979 Molecular & general genetics : MGG
Mutagen stability of alkylation-sensitive mutants of Bacillus subtilis. Prakash L 1972 Journal of bacteriology

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