Human Pol delta
From
H. sapiens
(aliases:Human pol δ)
(genes: POLD1)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol delta.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol delta
is a family B enzyme
from
H. sapiens.
Selected Properties for Human Pol delta: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Yes (4) | No (3) | no data | 1.0e-05 errors/bp (1) | no data |
- References (111)
- Structures (1)
- Sequences (1)
- Mutants (0)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Jessica L Sneeden, Sara M Grossi, Inger Tappin, Jerard Hurwitz, Wolf-Dietrich Heyer | Reconstitution of recombination-assoc... | |
| 2013 | JD Lormand, N Buncher, CT Murphy, P Kaur, Marietta Y W T Lee, P Burgers, Hongyun Wang, Thomas A Kunkel, Patricia L Opresko | DNA polymerase δ stalls on telomeric ... | |
| 2013 | Bo Cao, Zihan Zhang, Yuqin Zhang, Jinming Li, Gang Liang, Jianghong Ling | Effect of Smilax china L.-containing ... | |
| 2013 | Sufang Zhang, Hong Zhao, Zbiegniew Darzynkiewicz, Pengbo Zhou, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee | A novel function of CRL4Cdt2: regulat... | |
| 2013 | Szu Hua Sharon Lin, Xiaoxiao Wang, Sufang Zhang, Zhenzhong Zhang, Ernest Y C Lee, Marietta Y W T Lee | Dynamics of enzymatic interactions du... | |
| 2013 | Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani | The Human Tim/Tipin Complex Directly ... | |
| 2012 | Marietta Y W T Lee, Sufang Zhang, Szu Hua Sharon Lin, Jennifer Chea, Xiaoxiao Wang, Christine Leroy, Agnes Wong, Zhongtao Zhang, Ernest Y C Lee | Regulation of human DNA polymerase de... | |
| 2012 | Ashwini S Kamath-Loeb, Jiang-Cheng Shen, Michael W Schmitt, Lawrence A Loeb | The Werner syndrome exonuclease facil... | |
| 2012 | Sufang Zhang, Yajing Zhou, Ali Sarkeshik, John Yates, Timothy M Thomson, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee | Identification of RNF8 as a ubiquitin... | |
| 2012 | Zhenxin Hu, Senthil K Perumal, Hongjun Yue, Stephen J Benkovic | The human lagging strand DNA polymera... | |
| 2012 | Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja | Segregation of replicative DNA polyme... | |
| 2012 | Yajing Zhou, Xiao Meng, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee | Characterization of human DNA polymer... | |
| 2012 | Jennifer Chea, Sufang Zhang, Hong Zhao, Zhongtao Zhang, Ernest Y C Lee, Zbigniew Darzynkiewicz, Marietta Y W T Lee | Spatiotemporal recruitment of human D... | |
| 2012 | Zhenzhong Zhang, Sufang Zhang, Szu Hua Sharon Lin, Xiaoxiao Wang, Licheng Wu, Ernest Y C Lee, Marietta Y W T Lee | Structure of monoubiquitinated PCNA: ... | |
| 2011 | Ling Hui Xu, Mei Huang, Shou Guo Fang, Ding Xiang Liu | Coronavirus infection induces DNA rep... | |
| 2011 | Yujue Wang, Qian Zhang, Huiqing Chen, Xincang Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee, Yajing Zhou | P50, the Small Subunit of DNA Polymer... | |
| 2011 | Yanjiao Zhou, Huiqing Chen, Xincang Li, Yujue Wang, Keping Chen, Sufang Zhang, Xiao Meng, Ernest Y C Lee, Marietta Y W T Lee | Production of recombinant human DNA p... | Cloned or native,Tagged,Full length or truncated,Storage requirements,All properties |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2010 | Xiao Meng, Yanjiao Zhou, Ernest Y C Lee, Marietta Y W T Lee, David N Frick | The p12 subunit of human polymerase d... | |
| 2010 | Takeo Narita, Toshiki Tsurimoto, Junpei Yamamoto, Kana Nishihara, Kaori Ogawa, Eiji Ohashi, Terry Evans, Shigenori Iwai, Shunichi Takeda, Kouji Hirota | Human replicative DNA polymerase δ ca... | Template lesions,All properties |
| 2010 | Kensaku Sanefuji, Akinobu Taketomi, Tomohiro Iguchi, Keishi Sugimachi, Toru Ikegami, Yo-ichi Yamashita, Tomonobu Gion, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara | Significance of DNA polymerase delta ... | |
| 2010 | Linda J Reha-Krantz | DNA polymerase proofreading: Multiple... | |
| 2010 | Stephanie A Nick McElhinny, Brian E Watts, Dinesh Kumar, Danielle L Watt, Else-Britt Lundström, Peter M J Burgers, Erik Johansson, Andrei Chabes, Thomas A Kunkel | Abundant ribonucleotide incorporation... | KM,All properties |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Sandeep N Shah, Patricia L Opresko, Xiao Meng, Marietta Y W T Lee, Kristin A Eckert | DNA structure and the Werner protein ... | |
| 2010 | Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa | Consecutive incorporation of fluoroph... | |
| 2010 | Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich | Continued primer synthesis at stalled... | |
| 2009 | Xiao Meng, Yanjiao Zhou, Sufang Zhang, Ernest Y C Lee, David N Frick, Marietta Y W T Lee | DNA damage alters DNA polymerase delt... | |
| 2009 | Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin | Evolution of DNA polymerases: an inac... | |
| 2009 | Ruzaliya Fazlieva, Cynthia S Spittle, Darlene Morrissey, Harutoshi Hayashi, Hong Yan, Yoshihiro Matsumoto | Proofreading exonuclease activity of ... | |
| 2009 | Scott D McCulloch, Robert J Kokoska, Parie Garg, Peter M J Burgers, Thomas A Kunkel | The efficiency and fidelity of 8-oxo-... | |
| 2009 | Michael W Schmitt, Yoshihiro Matsumoto, Lawrence A Loeb | High fidelity and lesion bypass capab... | |
| 2009 | Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structure and activity relationship o... | |
| 2008 | Yan Gao, Yanjiao Zhou, Bin Xie, Sufang Zhang, Amal A Rahmeh, Hua-Shan Huang, Marietta Y W T Lee, Ernest Y C Lee | Protein phosphatase-1 is targeted to ... | |
| 2008 | Lionel Gellon, Dena R Carson, Jonathan P Carson, Bruce Demple | Intrinsic 5'-deoxyribose-5-phosphate ... | |
| 2008 | Lance D Langston, Mike E O'Donnell | DNA polymerase delta is highly proces... | |
| 2008 | Andrey G Baranovskiy, Nigar D Babayeva, Victoria G Liston, Igor B Rogozin, Eugene V Koonin, Youri I Pavlov, Dmitry G Vassylyev, Tahir H Tahirov | X-ray structure of the complex of reg... | |
| 2008 | Laure Lemmens, Serge Urbach, Renaud Prudent, Claude Cochet, Giuseppe Baldacci, Patrick Hughes | Phosphorylation of the C subunit (p66... | |
| 2008 | Nives Selak, Csanád Z Bachrati, Igor V Shevelev, Tobias Dietschy, Barbara van Loon, Anette Jacob, Ulrich Hübscher, Joerg D Hoheisel, Ian D Hickson, Igor Stagljar | The Bloom's syndrome helicase (BLM) i... | |
| 2006 | Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja | DNA polymerase epsilon associates wit... | |
| 2006 | Hao Li, Bin Xie, Yanjiao Zhou, Amal A Rahmeh, Sandra Trusa, Sufang Zhang, Yan Gao, Ernest Y C Lee, Marietta Y W T Lee | Functional roles of p12, the fourth s... | |
| 2006 | Geng Liu, Emma Warbrick | The p66 and p12 subunits of DNA polym... | |
| 2006 | Hao Li, Bin Xie, Amal A Rahmeh, Yanjiao Zhou, Marietta Y W T Lee | Direct interaction of p21 with p50, t... | |
| 2006 | Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich | Translesion synthesis across O6-alkyl... | |
| 2006 | Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich | Biochemical basis of genotoxicity of ... | |
| 2005 | J Richard G Pohler, Marit Otterlei, Emma Warbrick | An in vivo analysis of the localisati... | |
| 2005 | Jeong-Yun Choi, F Peter Guengerich | Adduct size limits efficient and erro... | |
| 2005 | Bin Xie, Hao Li, Qi Wang, Suqing Xie, Amal A Rahmeh, Wei Dai, Marietta Y W T Lee | Further characterization of human DNA... | |
| 2005 | Toshiki Tsurimoto, Ayako Shinozaki, Masaki Yano, Masayuki Seki, Takemi Enomoto | Human Werner helicase interacting pro... | |
| 2004 | Kenji Watanabe, Satoshi Tateishi, Michio Kawasuji, Toshiki Tsurimoto, Hirokazu Inoue, Masaru Yamaizumi | Rad18 guides poleta to replication st... | |
| 2004 | Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel | Evidence for interplay among yeast re... | 3-5' exo,5-3' exo,All properties |
| 2003 | Lingfeng Liu, Esther M Rodriguez-Belmonte, Nayef Mazloum, Bin Xie, Marietta Y W T Lee | Identification of a novel protein, PD... | |
| 2002 | Vladimir N Podust, Long-Sheng Chang, Robert Ott, Grigory L Dianov, Ellen Fanning | Reconstitution of human DNA polymeras... | |
| 2002 | Bin Xie, Nayef Mazloum, Lingfeng Liu, Amal A Rahmeh, Hao Li, Marietta Y W T Lee | Reconstitution and characterization o... | |
| 2002 | Naomi Suzuki, Eiji Ohashi, Alexander Kolbanovskiy, Nicholas E Geacintov, Arthur P Grollman, Haruo Ohmori, Shinya Shibutani | Translesion synthesis by human DNA po... | |
| 2002 | Lajos Haracska, Louise Prakash, Satya Prakash | Role of human DNA polymerase kappa as... | |
| 2001 | A J Podlutsky, Irina I Dianova, Vladimir N Podust, Vilhelm A Bohr, Grigory L Dianov | Human DNA polymerase beta initiates D... | |
| 2001 | B Li, Marietta Y W T Lee | Transcriptional regulation of the hum... | |
| 2001 | K Shikata, S Ohta, Kohei Yamada, C Obuse, Hirofumi Yoshikawa, Toshiki Tsurimoto | The human homologue of fission Yeast ... | |
| 2001 | Yong Hwan Jin, R Obert, Peter M J Burgers, Thomas A Kunkel, Michael A Resnick, Dmitry A Gordenin | The 3'-->5' exonuclease of DNA polyme... | 3-5' exo,All properties |
| 2001 | M Ducoux, Serge Urbach, Giuseppe Baldacci, Ulrich Hübscher, Stéphane Koundrioukoff, J Christensen, Patrick Hughes | Mediation of proliferating cell nucle... | |
| 2000 | A Perez, A Leon, Marietta Y W T Lee | Characterization of the 5'-flanking r... | |
| 2000 | Lingfeng Liu, J Mo, Esther M Rodriguez-Belmonte, Marietta Y W T Lee | Identification of a fourth subunit of... | |
| 2000 | Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel | Fidelity and processivity of DNA synt... | Nucleotide Substitution Rate,All properties |
| 2000 | H J Einolf, F Peter Guengerich | Kinetic analysis of nucleotide incorp... | KM,kcat,All properties |
| 2000 | S W Wang, T Toda, R MacCallum, A L Harris, C Norbury | Cid1, a fission yeast protein require... | |
| 2000 | A M Szekely, Y H Chen, C Zhang, J Oshima, S M Weissman | Werner protein recruits DNA polymeras... | |
| 2000 | S J Araújo, F Tirode, F Coin, Helmut Pospiech, Juhani E Syväoja, M Stucki, Ulrich Hübscher, J M Egly, Richard D Wood | Nucleotide excision repair of DNA wit... | |
| 2000 | S Suzuki, Motoshi Suzuki, Shonen Yoshida | Characterization of the human DNA pol... | |
| 1998 | S M Wu, Peiming Zhang, X R Zeng, S J Zhang, J Mo, B Q Li, Marietta Y W T Lee | Characterization of the p125 subunit ... | |
| 1998 | Peiming Zhang, Younguk Sun, H Hsu, Linqi Zhang, Yongqing Zhang, Marietta Y W T Lee | The interdomain connector loop of hum... | |
| 1997 | Younguk Sun, Yanan Jiang, Peiming Zhang, S J Zhang, Yanjiao Zhou, B Q Li, N L Toomey, Marietta Y W T Lee | Expression and characterization of th... | |
| 1997 | Jin-Qiu Zhou, H He, Cheng-Keat Tan, Kathleen M Downey, Antero G So | The small subunit is required for fun... | |
| 1996 | S Ceccotti, G Aquilina, Peter Macpherson, Masami Yamada, Peter Karran, Margherita Bignami | Processing of O6-methylguanine by mis... | |
| 1996 | Dmitry Ju Mozzherin, Maeve McConnell, M V Jasko, A A Krayevsky, Cheng-Keat Tan, Kathleen M Downey, Paul A Fisher | Proliferating cell nuclear antigen pr... | |
| 1996 | Polina V Shcherbakova, V N Noskov, M R Pshenichnov, Youri I Pavlov | Base analog 6-N-hydroxylaminopurine m... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,Molecular Weight,All properties |
| 1996 | Jacqueline M Gulbis, Zvi Kelman, Jerard Hurwitz, Mike E O'Donnell, John Kuriyan | Structure of the C-terminal region of... | |
| 1996 | Jin-Qiu Zhou, Cheng-Keat Tan, Antero G So, Kathleen M Downey | Purification and characterization of ... | |
| 1995 | S J Zhang, X R Zeng, Peiming Zhang, N L Toomey, R Y Chuang, Long-Sheng Chang, Marietta Y W T Lee | A conserved region in the amino termi... | |
| 1995 | Peiming Zhang, S J Zhang, Zhenzhong Zhang, J F Woessner, Marietta Y W T Lee | Expression and physicochemical charac... | |
| 1995 | Long-Sheng Chang, L Zhao, L Zhu, M L Chen, Marietta Y W T Lee | Structure of the gene for the catalyt... | |
| 1995 | T Melendy, Juhan Sedman, A Stenlund | Cellular factors required for papillo... | |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1995 | Yanan Jiang, S J Zhang, S M Wu, Marietta Y W T Lee | Immunoaffinity purification of DNA po... | |
| 1995 | Peiming Zhang, I Frugulhetti, Yanan Jiang, G L Holt, R C Condit, Marietta Y W T Lee | Expression of the catalytic subunit o... | |
| 1994 | Takehisa Matsumoto, S Hata, I Suzuka, Junji Hashimoto | Expression of functional proliferatin... | |
| 1994 | X R Zeng, H Hao, Yanan Jiang, Marietta Y W T Lee | Regulation of human DNA polymerase de... | |
| 1994 | Xincang Li, Peter M J Burgers | Molecular cloning and expression of t... | |
| 1994 | L M Podust, Vladimir N Podust, C Floth, Ulrich Hübscher | Assembly of DNA polymerase delta and ... | |
| 1993 | S H Lee | The 3'-5' exonuclease of human DNA po... | |
| 1993 | Vladimir N Podust, Ulrich Hübscher | Lagging strand DNA synthesis by calf ... | |
| 1993 | Dmitry A Gordenin, K S Lobachev, N P Degtyareva, A L Malkova, E Perkins, Michael A Resnick | Inverted DNA repeats: a source of euk... | |
| 1992 | H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee | Structural and functional relationshi... | |
| 1992 | Silvio Spadari, Federico Focher, Ulrich Hübscher | Developmental activity profile of DNA... | |
| 1992 | Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick | Transposon Tn5 excision in yeast: inf... | |
| 1992 | DNA Replication | ||
| 1992 | C L Yang, Long-Sheng Chang, Peiming Zhang, H Hao, L Zhu, N L Toomey, Marietta Y W T Lee | Molecular cloning of the cDNA for the... | |
| 1992 | R R Kemper, E R Ahn, Peiming Zhang, Marietta Y W T Lee, M Rabin | Human DNA polymerase delta gene maps ... | |
| 1991 | T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher | Biochemical and functional comparison... | Full length or truncated,Specific Activity,Processivity,3-5' exo,5-3' exo,Molecular Weight,3-5' Exo Specific Activity,RNase H,All properties |
| 1991 | Marietta Y W T Lee, Y Q Jiang, S J Zhang, N L Toomey | Characterization of human DNA polymer... | |
| 1991 | B A Fox, D J Bzik | The primary structure of Plasmodium f... | |
| 1991 | D W Chung, J A Zhang, Cheng-Keat Tan, E W Davie, Antero G So, Kathleen M Downey | Primary structure of the catalytic su... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1989 | Federico Focher, M Gassmann, P Hafkemeyer, Elena Ferrari, Silvio Spadari, Ulrich Hübscher | Calf thymus DNA polymerase delta inde... | |
| 1988 | G A Bauer, Peter M J Burgers | The yeast analog of mammalian cyclin/... | |
| 1986 | Marietta Y W T Lee, N L Toomey | Differential effects of dimethylsulfo... | |
| 1986 | Cheng-Keat Tan, C Castillo, Antero G So, Kathleen M Downey | An auxiliary protein for DNA polymera... | |
| 1981 | M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari | An autoradiographic demonstration of ... | |
| 1980 | G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch | Synchronization of HeLa cell cultures... | |
| 1976 | J J Byrnes, Kathleen M Downey, V L Black, Antero G So | A new mammalian DNA polymerase with 3... |
Protein sequence:
Predicted Structure Model
Predicted model
AlphaFold DB
Not experimentally determined
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
Protein information: Uniprot P28340 search for Human Pol delta at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-P28340-F1