Human Pol delta
From
H. sapiens
(aliases:Human pol δ)
(genes: POLD1)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol delta.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol delta
is a family B enzyme
from
H. sapiens.
Selected Properties for Human Pol delta: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Yes (4) | No (3) | no data | 1.0e-05 errors/bp (1) | no data |
- References (111)
- Structures (0)
- Sequences (1)
- Mutants (0)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Jessica L Sneeden, Sara M Grossi, Inger Tappin, Jerard Hurwitz, Wolf-Dietrich Heyer | Reconstitution of recombination-assoc... | |
| 2013 | JD Lormand, N Buncher, CT Murphy, P Kaur, Marietta Y W T Lee, P Burgers, Hongyun Wang, Thomas A Kunkel, Patricia L Opresko | DNA polymerase δ stalls on telomeric ... | |
| 2013 | Bo Cao, Zihan Zhang, Yuqin Zhang, Jinming Li, Gang Liang, Jianghong Ling | Effect of Smilax china L.-containing ... | |
| 2013 | Sufang Zhang, Hong Zhao, Zbiegniew Darzynkiewicz, Pengbo Zhou, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee | A novel function of CRL4Cdt2: regulat... | |
| 2013 | Szu Hua Sharon Lin, Xiaoxiao Wang, Sufang Zhang, Zhenzhong Zhang, Ernest Y C Lee, Marietta Y W T Lee | Dynamics of enzymatic interactions du... | |
| 2013 | Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani | The Human Tim/Tipin Complex Directly ... | |
| 2012 | Marietta Y W T Lee, Sufang Zhang, Szu Hua Sharon Lin, Jennifer Chea, Xiaoxiao Wang, Christine Leroy, Agnes Wong, Zhongtao Zhang, Ernest Y C Lee | Regulation of human DNA polymerase de... | |
| 2012 | Ashwini S Kamath-Loeb, Jiang-Cheng Shen, Michael W Schmitt, Lawrence A Loeb | The Werner syndrome exonuclease facil... | |
| 2012 | Sufang Zhang, Yajing Zhou, Ali Sarkeshik, John Yates, Timothy M Thomson, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee | Identification of RNF8 as a ubiquitin... | |
| 2012 | Zhenxin Hu, Senthil K Perumal, Hongjun Yue, Stephen J Benkovic | The human lagging strand DNA polymera... | |
| 2012 | Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja | Segregation of replicative DNA polyme... | |
| 2012 | Yajing Zhou, Xiao Meng, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee | Characterization of human DNA polymer... | |
| 2012 | Jennifer Chea, Sufang Zhang, Hong Zhao, Zhongtao Zhang, Ernest Y C Lee, Zbigniew Darzynkiewicz, Marietta Y W T Lee | Spatiotemporal recruitment of human D... | |
| 2012 | Zhenzhong Zhang, Sufang Zhang, Szu Hua Sharon Lin, Xiaoxiao Wang, Licheng Wu, Ernest Y C Lee, Marietta Y W T Lee | Structure of monoubiquitinated PCNA: ... | |
| 2011 | Ling Hui Xu, Mei Huang, Shou Guo Fang, Ding Xiang Liu | Coronavirus infection induces DNA rep... | |
| 2011 | Yujue Wang, Qian Zhang, Huiqing Chen, Xincang Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee, Yajing Zhou | P50, the Small Subunit of DNA Polymer... | |
| 2011 | Yanjiao Zhou, Huiqing Chen, Xincang Li, Yujue Wang, Keping Chen, Sufang Zhang, Xiao Meng, Ernest Y C Lee, Marietta Y W T Lee | Production of recombinant human DNA p... | Cloned or native,Tagged,Full length or truncated,Storage requirements,All properties |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2010 | Xiao Meng, Yanjiao Zhou, Ernest Y C Lee, Marietta Y W T Lee, David N Frick | The p12 subunit of human polymerase d... | |
| 2010 | Takeo Narita, Toshiki Tsurimoto, Junpei Yamamoto, Kana Nishihara, Kaori Ogawa, Eiji Ohashi, Terry Evans, Shigenori Iwai, Shunichi Takeda, Kouji Hirota | Human replicative DNA polymerase δ ca... | Template lesions,All properties |
| 2010 | Kensaku Sanefuji, Akinobu Taketomi, Tomohiro Iguchi, Keishi Sugimachi, Toru Ikegami, Yo-ichi Yamashita, Tomonobu Gion, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara | Significance of DNA polymerase delta ... | |
| 2010 | Linda J Reha-Krantz | DNA polymerase proofreading: Multiple... | |
| 2010 | Stephanie A Nick McElhinny, Brian E Watts, Dinesh Kumar, Danielle L Watt, Else-Britt Lundström, Peter M J Burgers, Erik Johansson, Andrei Chabes, Thomas A Kunkel | Abundant ribonucleotide incorporation... | KM,All properties |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Sandeep N Shah, Patricia L Opresko, Xiao Meng, Marietta Y W T Lee, Kristin A Eckert | DNA structure and the Werner protein ... | |
| 2010 | Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa | Consecutive incorporation of fluoroph... | |
| 2010 | Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich | Continued primer synthesis at stalled... | |
| 2009 | Xiao Meng, Yanjiao Zhou, Sufang Zhang, Ernest Y C Lee, David N Frick, Marietta Y W T Lee | DNA damage alters DNA polymerase delt... | |
| 2009 | Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin | Evolution of DNA polymerases: an inac... | |
| 2009 | Ruzaliya Fazlieva, Cynthia S Spittle, Darlene Morrissey, Harutoshi Hayashi, Hong Yan, Yoshihiro Matsumoto | Proofreading exonuclease activity of ... | |
| 2009 | Scott D McCulloch, Robert J Kokoska, Parie Garg, Peter M J Burgers, Thomas A Kunkel | The efficiency and fidelity of 8-oxo-... | |
| 2009 | Michael W Schmitt, Yoshihiro Matsumoto, Lawrence A Loeb | High fidelity and lesion bypass capab... | |
| 2009 | Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structure and activity relationship o... | |
| 2008 | Yan Gao, Yanjiao Zhou, Bin Xie, Sufang Zhang, Amal A Rahmeh, Hua-Shan Huang, Marietta Y W T Lee, Ernest Y C Lee | Protein phosphatase-1 is targeted to ... | |
| 2008 | Lionel Gellon, Dena R Carson, Jonathan P Carson, Bruce Demple | Intrinsic 5'-deoxyribose-5-phosphate ... | |
| 2008 | Lance D Langston, Mike E O'Donnell | DNA polymerase delta is highly proces... | |
| 2008 | Andrey G Baranovskiy, Nigar D Babayeva, Victoria G Liston, Igor B Rogozin, Eugene V Koonin, Youri I Pavlov, Dmitry G Vassylyev, Tahir H Tahirov | X-ray structure of the complex of reg... | |
| 2008 | Laure Lemmens, Serge Urbach, Renaud Prudent, Claude Cochet, Giuseppe Baldacci, Patrick Hughes | Phosphorylation of the C subunit (p66... | |
| 2008 | Nives Selak, Csanád Z Bachrati, Igor V Shevelev, Tobias Dietschy, Barbara van Loon, Anette Jacob, Ulrich Hübscher, Joerg D Hoheisel, Ian D Hickson, Igor Stagljar | The Bloom's syndrome helicase (BLM) i... | |
| 2006 | Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja | DNA polymerase epsilon associates wit... | |
| 2006 | Hao Li, Bin Xie, Yanjiao Zhou, Amal A Rahmeh, Sandra Trusa, Sufang Zhang, Yan Gao, Ernest Y C Lee, Marietta Y W T Lee | Functional roles of p12, the fourth s... | |
| 2006 | Geng Liu, Emma Warbrick | The p66 and p12 subunits of DNA polym... | |
| 2006 | Hao Li, Bin Xie, Amal A Rahmeh, Yanjiao Zhou, Marietta Y W T Lee | Direct interaction of p21 with p50, t... | |
| 2006 | Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich | Translesion synthesis across O6-alkyl... | |
| 2006 | Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich | Biochemical basis of genotoxicity of ... | |
| 2005 | J Richard G Pohler, Marit Otterlei, Emma Warbrick | An in vivo analysis of the localisati... | |
| 2005 | Jeong-Yun Choi, F Peter Guengerich | Adduct size limits efficient and erro... | |
| 2005 | Bin Xie, Hao Li, Qi Wang, Suqing Xie, Amal A Rahmeh, Wei Dai, Marietta Y W T Lee | Further characterization of human DNA... | |
| 2005 | Toshiki Tsurimoto, Ayako Shinozaki, Masaki Yano, Masayuki Seki, Takemi Enomoto | Human Werner helicase interacting pro... | |
| 2004 | Kenji Watanabe, Satoshi Tateishi, Michio Kawasuji, Toshiki Tsurimoto, Hirokazu Inoue, Masaru Yamaizumi | Rad18 guides poleta to replication st... | |
| 2004 | Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel | Evidence for interplay among yeast re... | 3-5' exo,5-3' exo,All properties |
| 2003 | Lingfeng Liu, Esther M Rodriguez-Belmonte, Nayef Mazloum, Bin Xie, Marietta Y W T Lee | Identification of a novel protein, PD... | |
| 2002 | Vladimir N Podust, Long-Sheng Chang, Robert Ott, Grigory L Dianov, Ellen Fanning | Reconstitution of human DNA polymeras... | |
| 2002 | Bin Xie, Nayef Mazloum, Lingfeng Liu, Amal A Rahmeh, Hao Li, Marietta Y W T Lee | Reconstitution and characterization o... | |
| 2002 | Naomi Suzuki, Eiji Ohashi, Alexander Kolbanovskiy, Nicholas E Geacintov, Arthur P Grollman, Haruo Ohmori, Shinya Shibutani | Translesion synthesis by human DNA po... | |
| 2002 | Lajos Haracska, Louise Prakash, Satya Prakash | Role of human DNA polymerase kappa as... | |
| 2001 | A J Podlutsky, Irina I Dianova, Vladimir N Podust, Vilhelm A Bohr, Grigory L Dianov | Human DNA polymerase beta initiates D... | |
| 2001 | B Li, Marietta Y W T Lee | Transcriptional regulation of the hum... | |
| 2001 | K Shikata, S Ohta, Kohei Yamada, C Obuse, Hirofumi Yoshikawa, Toshiki Tsurimoto | The human homologue of fission Yeast ... | |
| 2001 | Yong Hwan Jin, R Obert, Peter M J Burgers, Thomas A Kunkel, Michael A Resnick, Dmitry A Gordenin | The 3'-->5' exonuclease of DNA polyme... | 3-5' exo,All properties |
| 2001 | M Ducoux, Serge Urbach, Giuseppe Baldacci, Ulrich Hübscher, Stéphane Koundrioukoff, J Christensen, Patrick Hughes | Mediation of proliferating cell nucle... | |
| 2000 | A Perez, A Leon, Marietta Y W T Lee | Characterization of the 5'-flanking r... | |
| 2000 | Lingfeng Liu, J Mo, Esther M Rodriguez-Belmonte, Marietta Y W T Lee | Identification of a fourth subunit of... | |
| 2000 | Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel | Fidelity and processivity of DNA synt... | Nucleotide Substitution Rate,All properties |
| 2000 | H J Einolf, F Peter Guengerich | Kinetic analysis of nucleotide incorp... | KM,kcat,All properties |
| 2000 | S W Wang, T Toda, R MacCallum, A L Harris, C Norbury | Cid1, a fission yeast protein require... | |
| 2000 | A M Szekely, Y H Chen, C Zhang, J Oshima, S M Weissman | Werner protein recruits DNA polymeras... | |
| 2000 | S J Araújo, F Tirode, F Coin, Helmut Pospiech, Juhani E Syväoja, M Stucki, Ulrich Hübscher, J M Egly, Richard D Wood | Nucleotide excision repair of DNA wit... | |
| 2000 | S Suzuki, Motoshi Suzuki, Shonen Yoshida | Characterization of the human DNA pol... | |
| 1998 | S M Wu, Peiming Zhang, X R Zeng, S J Zhang, J Mo, B Q Li, Marietta Y W T Lee | Characterization of the p125 subunit ... | |
| 1998 | Peiming Zhang, Younguk Sun, H Hsu, Linqi Zhang, Yongqing Zhang, Marietta Y W T Lee | The interdomain connector loop of hum... | |
| 1997 | Younguk Sun, Yanan Jiang, Peiming Zhang, S J Zhang, Yanjiao Zhou, B Q Li, N L Toomey, Marietta Y W T Lee | Expression and characterization of th... | |
| 1997 | Jin-Qiu Zhou, H He, Cheng-Keat Tan, Kathleen M Downey, Antero G So | The small subunit is required for fun... | |
| 1996 | S Ceccotti, G Aquilina, Peter Macpherson, Masami Yamada, Peter Karran, Margherita Bignami | Processing of O6-methylguanine by mis... | |
| 1996 | Dmitry Ju Mozzherin, Maeve McConnell, M V Jasko, A A Krayevsky, Cheng-Keat Tan, Kathleen M Downey, Paul A Fisher | Proliferating cell nuclear antigen pr... | |
| 1996 | Polina V Shcherbakova, V N Noskov, M R Pshenichnov, Youri I Pavlov | Base analog 6-N-hydroxylaminopurine m... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,Molecular Weight,All properties |
| 1996 | Jacqueline M Gulbis, Zvi Kelman, Jerard Hurwitz, Mike E O'Donnell, John Kuriyan | Structure of the C-terminal region of... | |
| 1996 | Jin-Qiu Zhou, Cheng-Keat Tan, Antero G So, Kathleen M Downey | Purification and characterization of ... | |
| 1995 | S J Zhang, X R Zeng, Peiming Zhang, N L Toomey, R Y Chuang, Long-Sheng Chang, Marietta Y W T Lee | A conserved region in the amino termi... | |
| 1995 | Peiming Zhang, S J Zhang, Zhenzhong Zhang, J F Woessner, Marietta Y W T Lee | Expression and physicochemical charac... | |
| 1995 | Long-Sheng Chang, L Zhao, L Zhu, M L Chen, Marietta Y W T Lee | Structure of the gene for the catalyt... | |
| 1995 | T Melendy, Juhan Sedman, A Stenlund | Cellular factors required for papillo... | |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1995 | Yanan Jiang, S J Zhang, S M Wu, Marietta Y W T Lee | Immunoaffinity purification of DNA po... | |
| 1995 | Peiming Zhang, I Frugulhetti, Yanan Jiang, G L Holt, R C Condit, Marietta Y W T Lee | Expression of the catalytic subunit o... | |
| 1994 | Takehisa Matsumoto, S Hata, I Suzuka, Junji Hashimoto | Expression of functional proliferatin... | |
| 1994 | X R Zeng, H Hao, Yanan Jiang, Marietta Y W T Lee | Regulation of human DNA polymerase de... | |
| 1994 | Xincang Li, Peter M J Burgers | Molecular cloning and expression of t... | |
| 1994 | L M Podust, Vladimir N Podust, C Floth, Ulrich Hübscher | Assembly of DNA polymerase delta and ... | |
| 1993 | S H Lee | The 3'-5' exonuclease of human DNA po... | |
| 1993 | Vladimir N Podust, Ulrich Hübscher | Lagging strand DNA synthesis by calf ... | |
| 1993 | Dmitry A Gordenin, K S Lobachev, N P Degtyareva, A L Malkova, E Perkins, Michael A Resnick | Inverted DNA repeats: a source of euk... | |
| 1992 | H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee | Structural and functional relationshi... | |
| 1992 | Silvio Spadari, Federico Focher, Ulrich Hübscher | Developmental activity profile of DNA... | |
| 1992 | Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick | Transposon Tn5 excision in yeast: inf... | |
| 1992 | DNA Replication | ||
| 1992 | C L Yang, Long-Sheng Chang, Peiming Zhang, H Hao, L Zhu, N L Toomey, Marietta Y W T Lee | Molecular cloning of the cDNA for the... | |
| 1992 | R R Kemper, E R Ahn, Peiming Zhang, Marietta Y W T Lee, M Rabin | Human DNA polymerase delta gene maps ... | |
| 1991 | T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher | Biochemical and functional comparison... | Full length or truncated,Specific Activity,Processivity,3-5' exo,5-3' exo,Molecular Weight,3-5' Exo Specific Activity,RNase H,All properties |
| 1991 | Marietta Y W T Lee, Y Q Jiang, S J Zhang, N L Toomey | Characterization of human DNA polymer... | |
| 1991 | B A Fox, D J Bzik | The primary structure of Plasmodium f... | |
| 1991 | D W Chung, J A Zhang, Cheng-Keat Tan, E W Davie, Antero G So, Kathleen M Downey | Primary structure of the catalytic su... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1989 | Federico Focher, M Gassmann, P Hafkemeyer, Elena Ferrari, Silvio Spadari, Ulrich Hübscher | Calf thymus DNA polymerase delta inde... | |
| 1988 | G A Bauer, Peter M J Burgers | The yeast analog of mammalian cyclin/... | |
| 1986 | Marietta Y W T Lee, N L Toomey | Differential effects of dimethylsulfo... | |
| 1986 | Cheng-Keat Tan, C Castillo, Antero G So, Kathleen M Downey | An auxiliary protein for DNA polymera... | |
| 1981 | M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari | An autoradiographic demonstration of ... | |
| 1980 | G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch | Synchronization of HeLa cell cultures... | |
| 1976 | J J Byrnes, Kathleen M Downey, V L Black, Antero G So | A new mammalian DNA polymerase with 3... |
Protein sequence:
Protein information: Uniprot P28340 search for Human Pol delta at UniProt
Sequence information: NCBI nucleotides European nucleotide archive