Human Pol delta

From H. sapiens (aliases:Human pol δ) (genes: POLD1)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol delta.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol delta is a family B enzyme from H. sapiens.

Selected Properties for Human Pol delta:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (4) No (3) no data 1.0e-05 errors/bp (1) no data
Year Authors Title Results by property
2013 Jessica L Sneeden, Sara M Grossi, Inger Tappin, Jerard Hurwitz, Wolf-Dietrich Heyer Reconstitution of recombination-assoc...
2013 JD Lormand, N Buncher, CT Murphy, P Kaur, Marietta Y W T Lee, P Burgers, Hongyun Wang, Thomas A Kunkel, Patricia L Opresko DNA polymerase δ stalls on telomeric ...
2013 Bo Cao, Zihan Zhang, Yuqin Zhang, Jinming Li, Gang Liang, Jianghong Ling Effect of Smilax china L.-containing ...
2013 Sufang Zhang, Hong Zhao, Zbiegniew Darzynkiewicz, Pengbo Zhou, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee A novel function of CRL4Cdt2: regulat...
2013 Szu Hua Sharon Lin, Xiaoxiao Wang, Sufang Zhang, Zhenzhong Zhang, Ernest Y C Lee, Marietta Y W T Lee Dynamics of enzymatic interactions du...
2013 Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani The Human Tim/Tipin Complex Directly ...
2012 Marietta Y W T Lee, Sufang Zhang, Szu Hua Sharon Lin, Jennifer Chea, Xiaoxiao Wang, Christine Leroy, Agnes Wong, Zhongtao Zhang, Ernest Y C Lee Regulation of human DNA polymerase de...
2012 Ashwini S Kamath-Loeb, Jiang-Cheng Shen, Michael W Schmitt, Lawrence A Loeb The Werner syndrome exonuclease facil...
2012 Sufang Zhang, Yajing Zhou, Ali Sarkeshik, John Yates, Timothy M Thomson, Zhongtao Zhang, Ernest Y C Lee, Marietta Y W T Lee Identification of RNF8 as a ubiquitin...
2012 Zhenxin Hu, Senthil K Perumal, Hongjun Yue, Stephen J Benkovic The human lagging strand DNA polymera...
2012 Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja Segregation of replicative DNA polyme...
2012 Yajing Zhou, Xiao Meng, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee Characterization of human DNA polymer...
2012 Jennifer Chea, Sufang Zhang, Hong Zhao, Zhongtao Zhang, Ernest Y C Lee, Zbigniew Darzynkiewicz, Marietta Y W T Lee Spatiotemporal recruitment of human D...
2012 Zhenzhong Zhang, Sufang Zhang, Szu Hua Sharon Lin, Xiaoxiao Wang, Licheng Wu, Ernest Y C Lee, Marietta Y W T Lee Structure of monoubiquitinated PCNA: ...
2011 Ling Hui Xu, Mei Huang, Shou Guo Fang, Ding Xiang Liu Coronavirus infection induces DNA rep...
2011 Yujue Wang, Qian Zhang, Huiqing Chen, Xincang Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee, Yajing Zhou P50, the Small Subunit of DNA Polymer...
2011 Yanjiao Zhou, Huiqing Chen, Xincang Li, Yujue Wang, Keping Chen, Sufang Zhang, Xiao Meng, Ernest Y C Lee, Marietta Y W T Lee Production of recombinant human DNA p... Cloned or native,Tagged,Full length or truncated,Storage requirements,All properties
2011 Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida Effects of quinone derivatives, such ...
2010 Xiao Meng, Yanjiao Zhou, Ernest Y C Lee, Marietta Y W T Lee, David N Frick The p12 subunit of human polymerase d...
2010 Takeo Narita, Toshiki Tsurimoto, Junpei Yamamoto, Kana Nishihara, Kaori Ogawa, Eiji Ohashi, Terry Evans, Shigenori Iwai, Shunichi Takeda, Kouji Hirota Human replicative DNA polymerase δ ca... Template lesions,All properties
2010 Kensaku Sanefuji, Akinobu Taketomi, Tomohiro Iguchi, Keishi Sugimachi, Toru Ikegami, Yo-ichi Yamashita, Tomonobu Gion, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara Significance of DNA polymerase delta ...
2010 Linda J Reha-Krantz DNA polymerase proofreading: Multiple...
2010 Stephanie A Nick McElhinny, Brian E Watts, Dinesh Kumar, Danielle L Watt, Else-Britt Lundström, Peter M J Burgers, Erik Johansson, Andrei Chabes, Thomas A Kunkel Abundant ribonucleotide incorporation... KM,All properties
2010 Mark D Sutton Coordinating DNA polymerase traffic d...
2010 Sandeep N Shah, Patricia L Opresko, Xiao Meng, Marietta Y W T Lee, Kristin A Eckert DNA structure and the Werner protein ...
2010 Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa Consecutive incorporation of fluoroph...
2010 Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich Continued primer synthesis at stalled...
2009 Xiao Meng, Yanjiao Zhou, Sufang Zhang, Ernest Y C Lee, David N Frick, Marietta Y W T Lee DNA damage alters DNA polymerase delt...
2009 Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin Evolution of DNA polymerases: an inac...
2009 Ruzaliya Fazlieva, Cynthia S Spittle, Darlene Morrissey, Harutoshi Hayashi, Hong Yan, Yoshihiro Matsumoto Proofreading exonuclease activity of ...
2009 Scott D McCulloch, Robert J Kokoska, Parie Garg, Peter M J Burgers, Thomas A Kunkel The efficiency and fidelity of 8-oxo-...
2009 Michael W Schmitt, Yoshihiro Matsumoto, Lawrence A Loeb High fidelity and lesion bypass capab...
2009 Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina Structure and activity relationship o...
2008 Yan Gao, Yanjiao Zhou, Bin Xie, Sufang Zhang, Amal A Rahmeh, Hua-Shan Huang, Marietta Y W T Lee, Ernest Y C Lee Protein phosphatase-1 is targeted to ...
2008 Lionel Gellon, Dena R Carson, Jonathan P Carson, Bruce Demple Intrinsic 5'-deoxyribose-5-phosphate ...
2008 Lance D Langston, Mike E O'Donnell DNA polymerase delta is highly proces...
2008 Andrey G Baranovskiy, Nigar D Babayeva, Victoria G Liston, Igor B Rogozin, Eugene V Koonin, Youri I Pavlov, Dmitry G Vassylyev, Tahir H Tahirov X-ray structure of the complex of reg...
2008 Laure Lemmens, Serge Urbach, Renaud Prudent, Claude Cochet, Giuseppe Baldacci, Patrick Hughes Phosphorylation of the C subunit (p66...
2008 Nives Selak, Csanád Z Bachrati, Igor V Shevelev, Tobias Dietschy, Barbara van Loon, Anette Jacob, Ulrich Hübscher, Joerg D Hoheisel, Ian D Hickson, Igor Stagljar The Bloom's syndrome helicase (BLM) i...
2006 Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja DNA polymerase epsilon associates wit...
2006 Hao Li, Bin Xie, Yanjiao Zhou, Amal A Rahmeh, Sandra Trusa, Sufang Zhang, Yan Gao, Ernest Y C Lee, Marietta Y W T Lee Functional roles of p12, the fourth s...
2006 Geng Liu, Emma Warbrick The p66 and p12 subunits of DNA polym...
2006 Hao Li, Bin Xie, Amal A Rahmeh, Yanjiao Zhou, Marietta Y W T Lee Direct interaction of p21 with p50, t...
2006 Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich Translesion synthesis across O6-alkyl...
2006 Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich Biochemical basis of genotoxicity of ...
2005 J Richard G Pohler, Marit Otterlei, Emma Warbrick An in vivo analysis of the localisati...
2005 Jeong-Yun Choi, F Peter Guengerich Adduct size limits efficient and erro...
2005 Bin Xie, Hao Li, Qi Wang, Suqing Xie, Amal A Rahmeh, Wei Dai, Marietta Y W T Lee Further characterization of human DNA...
2005 Toshiki Tsurimoto, Ayako Shinozaki, Masaki Yano, Masayuki Seki, Takemi Enomoto Human Werner helicase interacting pro...
2004 Kenji Watanabe, Satoshi Tateishi, Michio Kawasuji, Toshiki Tsurimoto, Hirokazu Inoue, Masaru Yamaizumi Rad18 guides poleta to replication st...
2004 Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel Evidence for interplay among yeast re... 3-5' exo,5-3' exo,All properties
2003 Lingfeng Liu, Esther M Rodriguez-Belmonte, Nayef Mazloum, Bin Xie, Marietta Y W T Lee Identification of a novel protein, PD...
2002 Vladimir N Podust, Long-Sheng Chang, Robert Ott, Grigory L Dianov, Ellen Fanning Reconstitution of human DNA polymeras...
2002 Bin Xie, Nayef Mazloum, Lingfeng Liu, Amal A Rahmeh, Hao Li, Marietta Y W T Lee Reconstitution and characterization o...
2002 Naomi Suzuki, Eiji Ohashi, Alexander Kolbanovskiy, Nicholas E Geacintov, Arthur P Grollman, Haruo Ohmori, Shinya Shibutani Translesion synthesis by human DNA po...
2002 Lajos Haracska, Louise Prakash, Satya Prakash Role of human DNA polymerase kappa as...
2001 A J Podlutsky, Irina I Dianova, Vladimir N Podust, Vilhelm A Bohr, Grigory L Dianov Human DNA polymerase beta initiates D...
2001 B Li, Marietta Y W T Lee Transcriptional regulation of the hum...
2001 K Shikata, S Ohta, Kohei Yamada, C Obuse, Hirofumi Yoshikawa, Toshiki Tsurimoto The human homologue of fission Yeast ...
2001 Yong Hwan Jin, R Obert, Peter M J Burgers, Thomas A Kunkel, Michael A Resnick, Dmitry A Gordenin The 3'-->5' exonuclease of DNA polyme... 3-5' exo,All properties
2001 M Ducoux, Serge Urbach, Giuseppe Baldacci, Ulrich Hübscher, Stéphane Koundrioukoff, J Christensen, Patrick Hughes Mediation of proliferating cell nucle...
2000 A Perez, A Leon, Marietta Y W T Lee Characterization of the 5'-flanking r...
2000 Lingfeng Liu, J Mo, Esther M Rodriguez-Belmonte, Marietta Y W T Lee Identification of a fourth subunit of...
2000 Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel Fidelity and processivity of DNA synt... Nucleotide Substitution Rate,All properties
2000 H J Einolf, F Peter Guengerich Kinetic analysis of nucleotide incorp... KM,kcat,All properties
2000 S W Wang, T Toda, R MacCallum, A L Harris, C Norbury Cid1, a fission yeast protein require...
2000 A M Szekely, Y H Chen, C Zhang, J Oshima, S M Weissman Werner protein recruits DNA polymeras...
2000 S J Araújo, F Tirode, F Coin, Helmut Pospiech, Juhani E Syväoja, M Stucki, Ulrich Hübscher, J M Egly, Richard D Wood Nucleotide excision repair of DNA wit...
2000 S Suzuki, Motoshi Suzuki, Shonen Yoshida Characterization of the human DNA pol...
1998 S M Wu, Peiming Zhang, X R Zeng, S J Zhang, J Mo, B Q Li, Marietta Y W T Lee Characterization of the p125 subunit ...
1998 Peiming Zhang, Younguk Sun, H Hsu, Linqi Zhang, Yongqing Zhang, Marietta Y W T Lee The interdomain connector loop of hum...
1997 Younguk Sun, Yanan Jiang, Peiming Zhang, S J Zhang, Yanjiao Zhou, B Q Li, N L Toomey, Marietta Y W T Lee Expression and characterization of th...
1997 Jin-Qiu Zhou, H He, Cheng-Keat Tan, Kathleen M Downey, Antero G So The small subunit is required for fun...
1996 S Ceccotti, G Aquilina, Peter Macpherson, Masami Yamada, Peter Karran, Margherita Bignami Processing of O6-methylguanine by mis...
1996 Dmitry Ju Mozzherin, Maeve McConnell, M V Jasko, A A Krayevsky, Cheng-Keat Tan, Kathleen M Downey, Paul A Fisher Proliferating cell nuclear antigen pr...
1996 Polina V Shcherbakova, V N Noskov, M R Pshenichnov, Youri I Pavlov Base analog 6-N-hydroxylaminopurine m...
1996 F B Perler, Sandeep Kumar, H Kong Thermostable DNA polymerases. Full length or truncated,3-5' exo,5-3' exo,Molecular Weight,All properties
1996 Jacqueline M Gulbis, Zvi Kelman, Jerard Hurwitz, Mike E O'Donnell, John Kuriyan Structure of the C-terminal region of...
1996 Jin-Qiu Zhou, Cheng-Keat Tan, Antero G So, Kathleen M Downey Purification and characterization of ...
1995 S J Zhang, X R Zeng, Peiming Zhang, N L Toomey, R Y Chuang, Long-Sheng Chang, Marietta Y W T Lee A conserved region in the amino termi...
1995 Peiming Zhang, S J Zhang, Zhenzhong Zhang, J F Woessner, Marietta Y W T Lee Expression and physicochemical charac...
1995 Long-Sheng Chang, L Zhao, L Zhu, M L Chen, Marietta Y W T Lee Structure of the gene for the catalyt...
1995 T Melendy, Juhan Sedman, A Stenlund Cellular factors required for papillo...
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Stereospecificity of human DNA polyme...
1995 Yanan Jiang, S J Zhang, S M Wu, Marietta Y W T Lee Immunoaffinity purification of DNA po...
1995 Peiming Zhang, I Frugulhetti, Yanan Jiang, G L Holt, R C Condit, Marietta Y W T Lee Expression of the catalytic subunit o...
1994 Takehisa Matsumoto, S Hata, I Suzuka, Junji Hashimoto Expression of functional proliferatin...
1994 X R Zeng, H Hao, Yanan Jiang, Marietta Y W T Lee Regulation of human DNA polymerase de...
1994 Xincang Li, Peter M J Burgers Molecular cloning and expression of t...
1994 L M Podust, Vladimir N Podust, C Floth, Ulrich Hübscher Assembly of DNA polymerase delta and ...
1993 S H Lee The 3'-5' exonuclease of human DNA po...
1993 Vladimir N Podust, Ulrich Hübscher Lagging strand DNA synthesis by calf ...
1993 Dmitry A Gordenin, K S Lobachev, N P Degtyareva, A L Malkova, E Perkins, Michael A Resnick Inverted DNA repeats: a source of euk...
1992 H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee Structural and functional relationshi...
1992 Silvio Spadari, Federico Focher, Ulrich Hübscher Developmental activity profile of DNA...
1992 Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick Transposon Tn5 excision in yeast: inf...
1992 DNA Replication
1992 C L Yang, Long-Sheng Chang, Peiming Zhang, H Hao, L Zhu, N L Toomey, Marietta Y W T Lee Molecular cloning of the cDNA for the...
1992 R R Kemper, E R Ahn, Peiming Zhang, Marietta Y W T Lee, M Rabin Human DNA polymerase delta gene maps ...
1991 T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher Biochemical and functional comparison... Full length or truncated,Specific Activity,Processivity,3-5' exo,5-3' exo,Molecular Weight,3-5' Exo Specific Activity,RNase H,All properties
1991 Marietta Y W T Lee, Y Q Jiang, S J Zhang, N L Toomey Characterization of human DNA polymer...
1991 B A Fox, D J Bzik The primary structure of Plasmodium f...
1991 D W Chung, J A Zhang, Cheng-Keat Tan, E W Davie, Antero G So, Kathleen M Downey Primary structure of the catalytic su...
1990 Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari Revised nomenclature for eukaryotic D...
1989 Federico Focher, M Gassmann, P Hafkemeyer, Elena Ferrari, Silvio Spadari, Ulrich Hübscher Calf thymus DNA polymerase delta inde...
1988 G A Bauer, Peter M J Burgers The yeast analog of mammalian cyclin/...
1986 Marietta Y W T Lee, N L Toomey Differential effects of dimethylsulfo...
1986 Cheng-Keat Tan, C Castillo, Antero G So, Kathleen M Downey An auxiliary protein for DNA polymera...
1981 M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari An autoradiographic demonstration of ...
1980 G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch Synchronization of HeLa cell cultures...
1976 J J Byrnes, Kathleen M Downey, V L Black, Antero G So A new mammalian DNA polymerase with 3...
Protein sequence:

Using Polbase tables:

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