Human Pol kappa

From H. sapiens (aliases:DINB) (genes: POLK)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol kappa.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol kappa is a family Y enzyme from H. sapiens.

Selected Properties for Human Pol kappa:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
No (3) no data 1.8e-03 errors/bp (1) 5.8e-03-6.6e-03 errors/bp (3) no data
Year Authors Title Results by property
S Sharma, CM Helchowski, CE Canman The roles of DNA polymerase ζ and the...
2014 Akira Sassa, Tetsuya Suzuki, Yuki Kanemaru, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Grúz, Manabu Yasui, Ramesh C Gupta, Francis Johnson, Toshihiro Ohta, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi In vivo evidence that phenylalanine 1...
2013 Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett Replication, Repair and Translesion P... Template lesions,All properties
2013 DJ Taggart, Terry L Camerlengo, Jason K Harrison, Shanen M Sherrer, Ajay K Kshetry, John-Stephen Taylor, Kun Huang, Zucai Suo A high-throughput and quantitative me...
2013 Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida Inhibitory effects of α-mangostin on ...
2013 Amit Ketkar, Maroof Khan Zafar, Leena Maddukuri, Kinrin Yamanaka, Surajit Banerjee, Martin Egli, Jeong-Yun Choi, R Stephen Lloyd, Robert Lawton Eoff Leukotriene biosynthesis inhibitor MK...
2012 Huifang Zhu, Yanfeng Fan, Jing Shen, Hongyan Qi, Jimin Shao Characterization of human DNA polymer...
2012 Kinrin Yamanaka, Dorjbal Dorjsuren, Robert Lawton Eoff, Martin Egli, David J Maloney, Ajit Jadhav, Anton Simeonov, R Stephen Lloyd A comprehensive strategy to discover ...
2012 Shanen M Sherrer, Laura E Sanman, Cynthia X Xia, Eric R Bolin, Chanchal K Malik, Georgia Efthimiopoulos, Ashis K Basu, Zucai Suo Kinetic Analysis of the Bypass of a B...
2012 Mathew Jk Jones, Luca Colnaghi, Tony T Huang Dysregulation of DNA polymerase κ rec...
2012 Jundong Zhou, Shuyu Zhang, Ling Xie, Pengfei Liu, Fang Xie, Jinchang Wu, Jianping Cao, Wei-Qun Ding Overexpression of DNA polymerase iota...
2012 Shanen M Sherrer, DJ Taggart, Lindsey R Pack, Chanchal K Malik, Ashis K Basu, Zucai Suo Quantitative analysis of the mutageni...
2011 Matthew G Pence, Patrick Blans, Charles N Zink, James C Fishbein, Fred W Perrino Bypass of N²-ethylguanine by human DN...
2011 Akira Sassa, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Grúz, Manabu Yasui, Ramesh C Gupta, Francis Johnson, Toshihiro Ohta, Takehiko Nohmi Phenylalanine 171 is a molecular brak...
2011 Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal Role of human DNA polymerase κ in ext...
2010 Mark D Sutton Coordinating DNA polymerase traffic d...
2009 Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato Structural basis for novel interactio...
2009 Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati Roy Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal Structure of human DNA polymerase kap...
2009 Adriana Irimia, Robert Lawton Eoff, F Peter Guengerich, Martin Egli Structural and functional elucidation...
2009 Rémy Bétous, Laurie Rey, Guliang Wang, Marie-Jeanne Pillaire, Nadine Puget, Janick Selves, Denis S F Biard, Kazuo Shin-ya, Karen M Vasquez, Christophe Cazaux, Jean-Sébastien Hoffmann Role of TLS DNA polymerases eta and k...
2009 Naoko Niimi, Akira Sassa, Atsushi Katafuchi, Petr Grúz, Hirofumi Fujimoto, Radha-Rani Bonala, Francis Johnson, Toshihiro Ohta, Takehiko Nohmi The steric gate amino acid tyrosine 1...
2009 Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov A real-time fluorescence method for e...
2009 Haijiang Zhang, Jeff W Beckman, F Peter Guengerich Frameshift deletion by Sulfolobus sol...
2008 Scott D McCulloch, Thomas A Kunkel The fidelity of DNA synthesis by euka... Frameshift Error Rate,Nucleotide Substitution Rate,All properties
2008 Lei Jia, Nicholas E Geacintov, Suse Broyde The N-clasp of human DNA polymerase k...
2008 Linda J Reha-Krantz Recent patents of gene sequences rela...
2007 Samer Lone, Sharon A Townson, Sacha N Uljon, Robert E Johnson, Amrita Brahma, Deepak T Nair, Satya Prakash, Louise Prakash, Aneel K Aggarwal Human DNA polymerase kappa encircles ...
2007 Wei Wen Yang, Roger Woodgate What a difference a decade makes: ins...
2007 Adam P Silverman, Qingfei Jiang, Myron F Goodman, Eric T Kool Steric and electrostatic effects in D...
2006 Chiu Hong Lee, Sushil Chandani, Edward L Loechler Homology modeling of four Y-family, l...
2006 William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash Replication past a trans-4-hydroxynon...
2006 Karissa D Carlson, Robert E Johnson, Louise Prakash, Satya Prakash, M Todd Washington Human DNA polymerase kappa forms nonp...
2006 Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich Translesion synthesis across O6-alkyl...
2006 Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich Biochemical basis of genotoxicity of ...
2006 Jeong-Yun Choi, Karen C Angel, F Peter Guengerich Translesion synthesis across bulky N2...
2005 Wei Wen Yang Portraits of a Y-family DNA polymerase.
2005 Clarisse Bavoux, Andréia Machado Leopoldino, Valérie Bergoglio, Jiyang O-Wang, Tomoo Ogi, Anne Bieth, Jean-Gabriel Judde, Sérgio Danilo Junho Pena, Marie-France Poupon, Thomas Helleday, Masatoshi Tagawa, Carlosrenato Machado, Jean-Sébastien Hoffmann, Christophe Cazaux Up-regulation of the error-prone DNA ...
2005 William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash Human DNA polymerase iota promotes re...
2005 Satya Prakash, Robert E Johnson, Louise Prakash Eukaryotic translesion synthesis DNA ...
2005 William T Wolfle, M Todd Washington, Eric T Kool, Thomas E Spratt, Sandra A Helquist, Louise Prakash, Satya Prakash Evidence for a Watson-Crick hydrogen ...
2004 Naomi Suzuki, Manabu Yasui, Y R Santosh Laxmi, Haruo Ohmori, Fumio Hanaoka, Shinya Shibutani Translesion synthesis past equine est...
2004 Sacha N Uljon, Robert E Johnson, Thomas A Edwards, Satya Prakash, Louise Prakash, Aneel K Aggarwal Crystal structure of the catalytic co...
2004 Naomi Suzuki, Shinji Itoh, Kinning Poon, Chikahide Masutani, Fumio Hanaoka, Haruo Ohmori, Itsuo Yoshizawa, Shinya Shibutani Translesion synthesis past estrogen-d...
2004 M Todd Washington, Irina G Minko, Robert E Johnson, William T Wolfle, Thomas M Harris, R Stephen Lloyd, Satya Prakash, Louise Prakash Efficient and error-free replication ...
2003 Thomas A Kunkel, Youri I Pavlov, Katarzyna Bebenek Functions of human DNA polymerases et... Full length or truncated,3-5' exo,Nucleotide Substitution Rate,All properties
2003 William T Wolfle, M Todd Washington, Louise Prakash, Satya Prakash Human DNA polymerase kappa uses templ...
2002 Lajos Haracska, Ildiko Unk, Robert E Johnson, Barbara B Phillips, Jerard Hurwitz, Louise Prakash, Satya Prakash Stimulation of DNA synthesis activity...
2002 Yongqing Zhang, Xiaoming Wu, Dongyu Guo, Olga Rechkoblit, Nicholas E Geacintov, Zhengqiang Wang Two-step error-prone bypass of the (+...
2002 Tomoo Ogi, Yoichi Shinkai, Kiyoji Tanaka, Haruo Ohmori Polkappa protects mammalian cells aga...
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Eukaryotic DNA polymerases.
2002 Valérie Bergoglio, Clarisse Bavoux, Vincent Verbiest, Jean-Sébastien Hoffmann, Christophe Cazaux Localisation of human DNA polymerase ...
2002 Paula L Fischhaber, Valerie L Gerlach, William J Feaver, Zafer Hatahet, Susan S Wallace, Errol C Friedberg Human DNA polymerase kappa bypasses a...
2002 Yongqing Zhang, Xiaoming Wu, Dongyu Guo, Olga Rechkoblit, Zhengqiang Wang Activities of human DNA polymerase ka...
2002 Lajos Haracska, Louise Prakash, Satya Prakash Role of human DNA polymerase kappa as...
2002 Naomi Suzuki, Eiji Ohashi, Alexander Kolbanovskiy, Nicholas E Geacintov, Arthur P Grollman, Haruo Ohmori, Shinya Shibutani Translesion synthesis by human DNA po...
2001 Naomi Suzuki, Eiji Ohashi, Kiyoshi Hayashi, Haruo Ohmori, Arthur P Grollman, Shinya Shibutani Translesional synthesis past acetylam...
2001 Valerie L Gerlach, William J Feaver, Paula L Fischhaber, Errol C Friedberg Purification and characterization of ... Cloned or native,Tagged,Tag Name,Full length or truncated,Processivity,3-5' exo,Template lesions,All properties
2000 Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, Michael Wang, Olga Rechkoblit, John-Stephen Taylor, Nicholas E Geacintov, Zhengqiang Wang Error-free and error-prone lesion byp...
2000 Yongqing Zhang, Fenghua Yuan, Hongkui Xin, Xiaoming Wu, D K Rajpal, D Yang, Zhengqiang Wang Human DNA polymerase kappa synthesize...
2000 Valerie L Gerlach, William J Feaver, Paula L Fischhaber, James A Richardson, L Aravind, Eugene V Koonin, Katarzyna Bebenek, Thomas A Kunkel, Errol C Friedberg Human DNA polymerase kappa: a novel D...
2000 Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel Fidelity and processivity of DNA synt... Cloned or native,Tagged,Tag Name,Full length or truncated,Processivity,Gap fill,3-5' exo,Nucleotide Substitution Rate,All properties
2000 Eiji Ohashi, Tomoo Ogi, Rika Kusumoto, Shigenori Iwai, Chikahide Masutani, Fumio Hanaoka, Haruo Ohmori Error-prone bypass of certain DNA les...
Protein sequence:
DNA sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Pol Kappa F171A
Pol Kappa (exo-) No (1) 7.4e-03 errors/bp (1)

Using Polbase tables:

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