Human Pol kappa
From
H. sapiens
(aliases:DINB)
(genes: POLK)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol kappa.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol kappa
is a family Y enzyme
from
H. sapiens.
Selected Properties for Human Pol kappa: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (3) | no data | 1.8e-03 errors/bp (1) | 5.8e-03-6.6e-03 errors/bp (3) | no data |
| Year | Authors | Title | Results by property |
|---|---|---|---|
| S Sharma, CM Helchowski, CE Canman | The roles of DNA polymerase ζ and the... | ||
| 2014 | Akira Sassa, Tetsuya Suzuki, Yuki Kanemaru, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Grúz, Manabu Yasui, Ramesh C Gupta, Francis Johnson, Toshihiro Ohta, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi | In vivo evidence that phenylalanine 1... | |
| 2013 | Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett | Replication, Repair and Translesion P... | Template lesions,All properties |
| 2013 | DJ Taggart, Terry L Camerlengo, Jason K Harrison, Shanen M Sherrer, Ajay K Kshetry, John-Stephen Taylor, Kun Huang, Zucai Suo | A high-throughput and quantitative me... | |
| 2013 | Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida | Inhibitory effects of α-mangostin on ... | |
| 2013 | Amit Ketkar, Maroof Khan Zafar, Leena Maddukuri, Kinrin Yamanaka, Surajit Banerjee, Martin Egli, Jeong-Yun Choi, R Stephen Lloyd, Robert Lawton Eoff | Leukotriene biosynthesis inhibitor MK... | |
| 2012 | Huifang Zhu, Yanfeng Fan, Jing Shen, Hongyan Qi, Jimin Shao | Characterization of human DNA polymer... | |
| 2012 | Kinrin Yamanaka, Dorjbal Dorjsuren, Robert Lawton Eoff, Martin Egli, David J Maloney, Ajit Jadhav, Anton Simeonov, R Stephen Lloyd | A comprehensive strategy to discover ... | |
| 2012 | Shanen M Sherrer, Laura E Sanman, Cynthia X Xia, Eric R Bolin, Chanchal K Malik, Georgia Efthimiopoulos, Ashis K Basu, Zucai Suo | Kinetic Analysis of the Bypass of a B... | |
| 2012 | Mathew Jk Jones, Luca Colnaghi, Tony T Huang | Dysregulation of DNA polymerase κ rec... | |
| 2012 | Jundong Zhou, Shuyu Zhang, Ling Xie, Pengfei Liu, Fang Xie, Jinchang Wu, Jianping Cao, Wei-Qun Ding | Overexpression of DNA polymerase iota... | |
| 2012 | Shanen M Sherrer, DJ Taggart, Lindsey R Pack, Chanchal K Malik, Ashis K Basu, Zucai Suo | Quantitative analysis of the mutageni... | |
| 2011 | Matthew G Pence, Patrick Blans, Charles N Zink, James C Fishbein, Fred W Perrino | Bypass of N²-ethylguanine by human DN... | |
| 2011 | Akira Sassa, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Grúz, Manabu Yasui, Ramesh C Gupta, Francis Johnson, Toshihiro Ohta, Takehiko Nohmi | Phenylalanine 171 is a molecular brak... | |
| 2011 | Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Role of human DNA polymerase κ in ext... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2009 | Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato | Structural basis for novel interactio... | |
| 2009 | Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati Roy Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal | Structure of human DNA polymerase kap... | |
| 2009 | Adriana Irimia, Robert Lawton Eoff, F Peter Guengerich, Martin Egli | Structural and functional elucidation... | |
| 2009 | Rémy Bétous, Laurie Rey, Guliang Wang, Marie-Jeanne Pillaire, Nadine Puget, Janick Selves, Denis S F Biard, Kazuo Shin-ya, Karen M Vasquez, Christophe Cazaux, Jean-Sébastien Hoffmann | Role of TLS DNA polymerases eta and k... | |
| 2009 | Naoko Niimi, Akira Sassa, Atsushi Katafuchi, Petr Grúz, Hirofumi Fujimoto, Radha-Rani Bonala, Francis Johnson, Toshihiro Ohta, Takehiko Nohmi | The steric gate amino acid tyrosine 1... | |
| 2009 | Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov | A real-time fluorescence method for e... | |
| 2009 | Haijiang Zhang, Jeff W Beckman, F Peter Guengerich | Frameshift deletion by Sulfolobus sol... | |
| 2008 | Scott D McCulloch, Thomas A Kunkel | The fidelity of DNA synthesis by euka... | Frameshift Error Rate,Nucleotide Substitution Rate,All properties |
| 2008 | Lei Jia, Nicholas E Geacintov, Suse Broyde | The N-clasp of human DNA polymerase k... | |
| 2008 | Linda J Reha-Krantz | Recent patents of gene sequences rela... | |
| 2007 | Samer Lone, Sharon A Townson, Sacha N Uljon, Robert E Johnson, Amrita Brahma, Deepak T Nair, Satya Prakash, Louise Prakash, Aneel K Aggarwal | Human DNA polymerase kappa encircles ... | |
| 2007 | Wei Wen Yang, Roger Woodgate | What a difference a decade makes: ins... | |
| 2007 | Adam P Silverman, Qingfei Jiang, Myron F Goodman, Eric T Kool | Steric and electrostatic effects in D... | |
| 2006 | Chiu Hong Lee, Sushil Chandani, Edward L Loechler | Homology modeling of four Y-family, l... | |
| 2006 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Replication past a trans-4-hydroxynon... | |
| 2006 | Karissa D Carlson, Robert E Johnson, Louise Prakash, Satya Prakash, M Todd Washington | Human DNA polymerase kappa forms nonp... | |
| 2006 | Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich | Translesion synthesis across O6-alkyl... | |
| 2006 | Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich | Biochemical basis of genotoxicity of ... | |
| 2006 | Jeong-Yun Choi, Karen C Angel, F Peter Guengerich | Translesion synthesis across bulky N2... | |
| 2005 | Wei Wen Yang | Portraits of a Y-family DNA polymerase. | |
| 2005 | Clarisse Bavoux, Andréia Machado Leopoldino, Valérie Bergoglio, Jiyang O-Wang, Tomoo Ogi, Anne Bieth, Jean-Gabriel Judde, Sérgio Danilo Junho Pena, Marie-France Poupon, Thomas Helleday, Masatoshi Tagawa, Carlosrenato Machado, Jean-Sébastien Hoffmann, Christophe Cazaux | Up-regulation of the error-prone DNA ... | |
| 2005 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Human DNA polymerase iota promotes re... | |
| 2005 | Satya Prakash, Robert E Johnson, Louise Prakash | Eukaryotic translesion synthesis DNA ... | |
| 2005 | William T Wolfle, M Todd Washington, Eric T Kool, Thomas E Spratt, Sandra A Helquist, Louise Prakash, Satya Prakash | Evidence for a Watson-Crick hydrogen ... | |
| 2004 | Naomi Suzuki, Manabu Yasui, Y R Santosh Laxmi, Haruo Ohmori, Fumio Hanaoka, Shinya Shibutani | Translesion synthesis past equine est... | |
| 2004 | Sacha N Uljon, Robert E Johnson, Thomas A Edwards, Satya Prakash, Louise Prakash, Aneel K Aggarwal | Crystal structure of the catalytic co... | |
| 2004 | Naomi Suzuki, Shinji Itoh, Kinning Poon, Chikahide Masutani, Fumio Hanaoka, Haruo Ohmori, Itsuo Yoshizawa, Shinya Shibutani | Translesion synthesis past estrogen-d... | |
| 2004 | M Todd Washington, Irina G Minko, Robert E Johnson, William T Wolfle, Thomas M Harris, R Stephen Lloyd, Satya Prakash, Louise Prakash | Efficient and error-free replication ... | |
| 2003 | Thomas A Kunkel, Youri I Pavlov, Katarzyna Bebenek | Functions of human DNA polymerases et... | Full length or truncated,3-5' exo,Nucleotide Substitution Rate,All properties |
| 2003 | William T Wolfle, M Todd Washington, Louise Prakash, Satya Prakash | Human DNA polymerase kappa uses templ... | |
| 2002 | Lajos Haracska, Ildiko Unk, Robert E Johnson, Barbara B Phillips, Jerard Hurwitz, Louise Prakash, Satya Prakash | Stimulation of DNA synthesis activity... | |
| 2002 | Yongqing Zhang, Xiaoming Wu, Dongyu Guo, Olga Rechkoblit, Nicholas E Geacintov, Zhengqiang Wang | Two-step error-prone bypass of the (+... | |
| 2002 | Tomoo Ogi, Yoichi Shinkai, Kiyoji Tanaka, Haruo Ohmori | Polkappa protects mammalian cells aga... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Valérie Bergoglio, Clarisse Bavoux, Vincent Verbiest, Jean-Sébastien Hoffmann, Christophe Cazaux | Localisation of human DNA polymerase ... | |
| 2002 | Paula L Fischhaber, Valerie L Gerlach, William J Feaver, Zafer Hatahet, Susan S Wallace, Errol C Friedberg | Human DNA polymerase kappa bypasses a... | |
| 2002 | Yongqing Zhang, Xiaoming Wu, Dongyu Guo, Olga Rechkoblit, Zhengqiang Wang | Activities of human DNA polymerase ka... | |
| 2002 | Lajos Haracska, Louise Prakash, Satya Prakash | Role of human DNA polymerase kappa as... | |
| 2002 | Naomi Suzuki, Eiji Ohashi, Alexander Kolbanovskiy, Nicholas E Geacintov, Arthur P Grollman, Haruo Ohmori, Shinya Shibutani | Translesion synthesis by human DNA po... | |
| 2001 | Naomi Suzuki, Eiji Ohashi, Kiyoshi Hayashi, Haruo Ohmori, Arthur P Grollman, Shinya Shibutani | Translesional synthesis past acetylam... | |
| 2001 | Valerie L Gerlach, William J Feaver, Paula L Fischhaber, Errol C Friedberg | Purification and characterization of ... | Cloned or native,Tagged,Tag Name,Full length or truncated,Processivity,3-5' exo,Template lesions,All properties |
| 2000 | Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, Michael Wang, Olga Rechkoblit, John-Stephen Taylor, Nicholas E Geacintov, Zhengqiang Wang | Error-free and error-prone lesion byp... | |
| 2000 | Yongqing Zhang, Fenghua Yuan, Hongkui Xin, Xiaoming Wu, D K Rajpal, D Yang, Zhengqiang Wang | Human DNA polymerase kappa synthesize... | |
| 2000 | Valerie L Gerlach, William J Feaver, Paula L Fischhaber, James A Richardson, L Aravind, Eugene V Koonin, Katarzyna Bebenek, Thomas A Kunkel, Errol C Friedberg | Human DNA polymerase kappa: a novel D... | |
| 2000 | Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel | Fidelity and processivity of DNA synt... | Cloned or native,Tagged,Tag Name,Full length or truncated,Processivity,Gap fill,3-5' exo,Nucleotide Substitution Rate,All properties |
| 2000 | Eiji Ohashi, Tomoo Ogi, Rika Kusumoto, Shigenori Iwai, Chikahide Masutani, Fumio Hanaoka, Haruo Ohmori | Error-prone bypass of certain DNA les... |
Protein sequence:
DNA sequence:
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Pol Kappa F171A | |||||
| Pol Kappa (exo-) | No (1) | 7.4e-03 errors/bp (1) |
Protein information: Uniprot Q9UBT6 search for Human Pol kappa at UniProt
Sequence information: NCBI nucleotides European nucleotide archive