Human Pol iota
From
H. sapiens
(aliases:Rad30)
(genes: POLI )
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol iota.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol iota
is a family Y enzyme
from
H. sapiens.
Selected Properties for Human Pol iota: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (2) | no data | no data | no data | 2.0e-04-3.0e-01 errors/bp (2) |
- References (67)
- Structures (20)
- Sequences (1)
- Mutants (0)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| S Sharma, CM Helchowski, CE Canman | The roles of DNA polymerase ζ and the... | ||
| 2013 | Fenghua Yuan, Zhigang Xu, Mingzhen Yang, Quanfang Wei, Yongqing Zhang, Jin Yu, Yi Zhi, Yang Liu, Zhiwen Chen, Jin Yang | Overexpressed DNA Polymerase Iota Reg... | |
| 2013 | DJ Taggart, Terry L Camerlengo, Jason K Harrison, Shanen M Sherrer, Ajay K Kshetry, John-Stephen Taylor, Kun Huang, Zucai Suo | A high-throughput and quantitative me... | |
| 2013 | Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett | Replication, Repair and Translesion P... | Template lesions,All properties |
| 2013 | Kevin N Kirouac, Ashis K Basu, Hong Ling | Replication of a carcinogenic nitropy... | |
| 2013 | A V Lakhin, A S Efremova, Irina V Makarova, E E Grishina, S I Shram, Vyacheslav Z Tarantul, Leonid V Gening | [Effect of Mn(II) on the error-prone ... | |
| 2012 | Irina V Makarova, Andrey A Kazakov, Alena V Makarova, Nella V Khaidarova, Larisa V Kozikova, Valentina V Nenasheva, Leonid V Gening, Vyacheslav Z Tarantul, Ludmila E Andreeva | Transient expression and activity of ... | |
| 2012 | Jundong Zhou, Shuyu Zhang, Ling Xie, Pengfei Liu, Fang Xie, Jinchang Wu, Jianping Cao, Wei-Qun Ding | Overexpression of DNA polymerase iota... | |
| 2012 | A V Makarova, A V Kulbachinskiy | Structure of human DNA polymerase iot... | |
| 2012 | Shanen M Sherrer, DJ Taggart, Lindsey R Pack, Chanchal K Malik, Ashis K Basu, Zucai Suo | Quantitative analysis of the mutageni... | |
| 2012 | Amit Ketkar, Maroof Khan Zafar, Surajit Banerjee, Victor E Marquez, Martin Egli, Robert Lawton Eoff | A nucleotide analogue induced gain of... | |
| 2012 | Shanen M Sherrer, Laura E Sanman, Cynthia X Xia, Eric R Bolin, Chanchal K Malik, Georgia Efthimiopoulos, Ashis K Basu, Zucai Suo | Kinetic Analysis of the Bypass of a B... | |
| 2011 | Leonid V Gening | DNA polymerase ι of mammals as a part... | |
| 2011 | Alena V Makarova, Corinn Grabow, Leonid V Gening, Vyacheslav Z Tarantul, Tahir H Tahirov, Tadayoshi Bessho, Youri I Pavlov | Inaccurate DNA synthesis in cell extr... | |
| 2010 | Matthew G Pence, Jeong-Yun Choi, Martin Egli, F Peter Guengerich | Structural basis for proficient incor... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Martha G Bomar, Sanjay D'Souza, Marzena Bienko, Ivan Dikic, Graham C Walker, Pei Zhou | Unconventional ubiquitin recognition ... | |
| 2009 | Kevin N Kirouac, Hong Ling | Structural basis of error-prone repli... | |
| 2009 | Jeong-Yun Choi, Seonhee Lim, Robert Lawton Eoff, F Peter Guengerich | Kinetic analysis of base-pairing pref... | |
| 2009 | Kerry Donny-Clark, Robert Shapiro, Suse Broyde | Accommodation of an N-(deoxyguanosin-... | |
| 2009 | Antonio E Vidal, Roger Woodgate | Insights into the cellular role of en... | |
| 2009 | Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov | A real-time fluorescence method for e... | |
| 2009 | Kerry Donny-Clark, Suse Broyde | Influence of local sequence context o... | |
| 2009 | Matthew G Pence, Patrick Blans, Charles N Zink, Thomas Hollis, James C Fishbein, Fred W Perrino | Lesion bypass of N2-ethylguanine by h... | |
| 2009 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | DNA synthesis across an abasic lesion... | |
| 2009 | Rinku Jain, Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Replication across template T/U by hu... | |
| 2009 | Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato | Structural basis for novel interactio... | |
| 2009 | Rémy Bétous, Laurie Rey, Guliang Wang, Marie-Jeanne Pillaire, Nadine Puget, Janick Selves, Denis S F Biard, Kazuo Shin-ya, Karen M Vasquez, Christophe Cazaux, Jean-Sébastien Hoffmann | Role of TLS DNA polymerases eta and k... | |
| 2008 | Junpei Yamamoto, David Loakes, Chikahide Masutani, Shizu Simmyo, Kumiko Urabe, Fumio Hanaoka, Philipp Holliger, Shigenori Iwai | Translesion synthesis across the (6-4... | |
| 2008 | Scott D McCulloch, Thomas A Kunkel | The fidelity of DNA synthesis by euka... | |
| 2008 | Tirzah Braz Petta, Satoshi Nakajima, Anastasia Zlatanou, Emmanuelle Despras, Sophie Couve-Privat, Alexander Ishchenko, Alain Sarasin, Akira Yasui, Patricia L Kannouche | Human DNA polymerase iota protects ce... | |
| 2008 | Asami Hishiki, Toshiyuki Shimizu, Tomo Hanafusa, Haruo Ohmori, Mamoru Sato, Hiroshi Hashimoto | Initial crystallographic study of hum... | |
| 2007 | Robert W Sobol | DNA polymerase beta null mouse embryo... | |
| 2007 | Wei Wen Yang, Roger Woodgate | What a difference a decade makes: ins... | |
| 2007 | Ekaterina G Frank, Roger Woodgate | Increased catalytic activity and alte... | |
| 2006 | Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich | Biochemical basis of genotoxicity of ... | |
| 2006 | Jeong-Yun Choi, F Peter Guengerich | Kinetic evidence for inefficient and ... | |
| 2006 | Robert E Johnson, Lajos Haracska, Louise Prakash, Satya Prakash | Role of hoogsteen edge hydrogen bondi... | |
| 2006 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Hoogsteen base pair formation promote... | |
| 2006 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Replication past a trans-4-hydroxynon... | |
| 2006 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | An incoming nucleotide imposes an ant... | |
| 2006 | Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich | Translesion synthesis across O6-alkyl... | |
| 2005 | Lajos Haracska, Narottam Acharya, Ildiko Unk, Robert E Johnson, Jerard Hurwitz, Louise Prakash, Satya Prakash | A single domain in human DNA polymera... | |
| 2005 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Human DNA polymerase iota promotes re... | |
| 2005 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Human DNA polymerase iota incorporate... | |
| 2005 | Robert E Johnson, Louise Prakash, Satya Prakash | Biochemical evidence for the requirem... | |
| 2004 | M Todd Washington, Irina G Minko, Robert E Johnson, William T Wolfle, Thomas M Harris, R Stephen Lloyd, Satya Prakash, Louise Prakash | Efficient and error-free replication ... | |
| 2004 | M Todd Washington, Robert E Johnson, Louise Prakash, Satya Prakash | Human DNA polymerase iota utilizes di... | |
| 2004 | Deepak T Nair, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal | Replication by human DNA polymerase-i... | |
| 2004 | Antonio E Vidal, Patricia L Kannouche, Vladimir N Podust, Wei Wen Yang, Alan R Lehmann, Roger Woodgate | Proliferating cell nuclear antigen-de... | |
| 2003 | Thomas A Kunkel, Youri I Pavlov, Katarzyna Bebenek | Functions of human DNA polymerases et... | Full length or truncated,Gap fill,3-5' exo,Overall Error Rate,All properties |
| 2003 | Alexandra Vaisman, Ekaterina G Frank, Shigenori Iwai, Eiji Ohashi, Haruo Ohmori, Fumio Hanaoka, Roger Woodgate | Sequence context-dependent replicatio... | |
| 2003 | Rajendra Prasad, Katarzyna Bebenek, Esther W Hou, David D Shock, William A Beard, Roger Woodgate, Thomas A Kunkel, Samuel H Wilson | Localization of the deoxyribose phosp... | |
| 2002 | Ahmad Faili, Said Aoufouchi, Eric Flatter, Quentin Guéranger, Claude-Agnès Reynaud, Jean-Claude Weill | Induction of somatic hypermutation in... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Ekaterina G Frank, Jane M Sayer, Heiko Kroth, Eiji Ohashi, Haruo Ohmori, Donald M Jerina, Roger Woodgate | Translesion replication of benzo[a]py... | |
| 2001 | M Sander | Human DNA polymerase iota: wrong for ... | |
| 2001 | Katarzyna Bebenek, Agnès Tissier, Ekaterina G Frank, John P McDonald, Rajendra Prasad, Samuel H Wilson, Roger Woodgate, Thomas A Kunkel | 5'-Deoxyribose phosphate lyase activi... | |
| 2001 | Alexandra Vaisman, Agnès Tissier, Ekaterina G Frank, Myron F Goodman, Roger Woodgate | Human DNA polymerase iota promiscuous... | |
| 2001 | Agnès Tissier, Ekaterina G Frank, John P McDonald, Alexandra Vaisman, A R Fernàndez de Henestrosa, François Boudsocq, M P McLenigan, Roger Woodgate | Biochemical characterization of human... | |
| 2001 | Lajos Haracska, Robert E Johnson, Ildiko Unk, Barbara B Phillips, Jerard Hurwitz, Louise Prakash, Satya Prakash | Targeting of human DNA polymerase iot... | |
| 2001 | Patricia J Gearhart, Richard D Wood | Emerging links between hypermutation ... | Associated condition,Overall Error Rate,All properties |
| 2001 | Ekaterina G Frank, Agnès Tissier, John P McDonald, V Rapić-Otrin, Xianmin Zeng, Patricia J Gearhart, Roger Woodgate | Altered nucleotide misinsertion fidel... | |
| 2001 | Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, John-Stephen Taylor, Zhengqiang Wang | Response of human DNA polymerase iota... | |
| 2000 | Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, Zhengqiang Wang | Preferential incorporation of G oppos... | 3-5' exo,All properties |
| 2000 | Agnès Tissier, John P McDonald, Ekaterina G Frank, Roger Woodgate | poliota, a remarkably error-prone hum... | |
| 2000 | Agnès Tissier, Ekaterina G Frank, John P McDonald, Shigenori Iwai, Fumio Hanaoka, Roger Woodgate | Misinsertion and bypass of thymine-th... |
Protein sequence:
Protein information: Uniprot Q9UNA4 search for Human Pol iota at UniProt
Sequence information: NCBI nucleotides European nucleotide archive