Human Pol iota
From
H. sapiens
(aliases:Rad30)
(genes: POLI )
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol iota.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol iota
is a family Y enzyme
from
H. sapiens.
Selected Properties for Human Pol iota: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (2) | no data | no data | no data | 2.0e-04-3.0e-01 errors/bp (2) |
- References (67)
- Structures (21)
- Sequences (1)
- Mutants (0)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| S Sharma, CM Helchowski, CE Canman | The roles of DNA polymerase ζ and the... | ||
| 2013 | Fenghua Yuan, Zhigang Xu, Mingzhen Yang, Quanfang Wei, Yongqing Zhang, Jin Yu, Yi Zhi, Yang Liu, Zhiwen Chen, Jin Yang | Overexpressed DNA Polymerase Iota Reg... | |
| 2013 | DJ Taggart, Terry L Camerlengo, Jason K Harrison, Shanen M Sherrer, Ajay K Kshetry, John-Stephen Taylor, Kun Huang, Zucai Suo | A high-throughput and quantitative me... | |
| 2013 | Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett | Replication, Repair and Translesion P... | Template lesions,All properties |
| 2013 | Kevin N Kirouac, Ashis K Basu, Hong Ling | Replication of a carcinogenic nitropy... | |
| 2013 | A V Lakhin, A S Efremova, Irina V Makarova, E E Grishina, S I Shram, Vyacheslav Z Tarantul, Leonid V Gening | [Effect of Mn(II) on the error-prone ... | |
| 2012 | Irina V Makarova, Andrey A Kazakov, Alena V Makarova, Nella V Khaidarova, Larisa V Kozikova, Valentina V Nenasheva, Leonid V Gening, Vyacheslav Z Tarantul, Ludmila E Andreeva | Transient expression and activity of ... | |
| 2012 | Jundong Zhou, Shuyu Zhang, Ling Xie, Pengfei Liu, Fang Xie, Jinchang Wu, Jianping Cao, Wei-Qun Ding | Overexpression of DNA polymerase iota... | |
| 2012 | A V Makarova, A V Kulbachinskiy | Structure of human DNA polymerase iot... | |
| 2012 | Shanen M Sherrer, DJ Taggart, Lindsey R Pack, Chanchal K Malik, Ashis K Basu, Zucai Suo | Quantitative analysis of the mutageni... | |
| 2012 | Amit Ketkar, Maroof Khan Zafar, Surajit Banerjee, Victor E Marquez, Martin Egli, Robert Lawton Eoff | A nucleotide analogue induced gain of... | |
| 2012 | Shanen M Sherrer, Laura E Sanman, Cynthia X Xia, Eric R Bolin, Chanchal K Malik, Georgia Efthimiopoulos, Ashis K Basu, Zucai Suo | Kinetic Analysis of the Bypass of a B... | |
| 2011 | Leonid V Gening | DNA polymerase ι of mammals as a part... | |
| 2011 | Alena V Makarova, Corinn Grabow, Leonid V Gening, Vyacheslav Z Tarantul, Tahir H Tahirov, Tadayoshi Bessho, Youri I Pavlov | Inaccurate DNA synthesis in cell extr... | |
| 2010 | Matthew G Pence, Jeong-Yun Choi, Martin Egli, F Peter Guengerich | Structural basis for proficient incor... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Martha G Bomar, Sanjay D'Souza, Marzena Bienko, Ivan Dikic, Graham C Walker, Pei Zhou | Unconventional ubiquitin recognition ... | |
| 2009 | Kevin N Kirouac, Hong Ling | Structural basis of error-prone repli... | |
| 2009 | Jeong-Yun Choi, Seonhee Lim, Robert Lawton Eoff, F Peter Guengerich | Kinetic analysis of base-pairing pref... | |
| 2009 | Kerry Donny-Clark, Robert Shapiro, Suse Broyde | Accommodation of an N-(deoxyguanosin-... | |
| 2009 | Antonio E Vidal, Roger Woodgate | Insights into the cellular role of en... | |
| 2009 | Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov | A real-time fluorescence method for e... | |
| 2009 | Kerry Donny-Clark, Suse Broyde | Influence of local sequence context o... | |
| 2009 | Matthew G Pence, Patrick Blans, Charles N Zink, Thomas Hollis, James C Fishbein, Fred W Perrino | Lesion bypass of N2-ethylguanine by h... | |
| 2009 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | DNA synthesis across an abasic lesion... | |
| 2009 | Rinku Jain, Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Replication across template T/U by hu... | |
| 2009 | Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato | Structural basis for novel interactio... | |
| 2009 | Rémy Bétous, Laurie Rey, Guliang Wang, Marie-Jeanne Pillaire, Nadine Puget, Janick Selves, Denis S F Biard, Kazuo Shin-ya, Karen M Vasquez, Christophe Cazaux, Jean-Sébastien Hoffmann | Role of TLS DNA polymerases eta and k... | |
| 2008 | Junpei Yamamoto, David Loakes, Chikahide Masutani, Shizu Simmyo, Kumiko Urabe, Fumio Hanaoka, Philipp Holliger, Shigenori Iwai | Translesion synthesis across the (6-4... | |
| 2008 | Scott D McCulloch, Thomas A Kunkel | The fidelity of DNA synthesis by euka... | |
| 2008 | Tirzah Braz Petta, Satoshi Nakajima, Anastasia Zlatanou, Emmanuelle Despras, Sophie Couve-Privat, Alexander Ishchenko, Alain Sarasin, Akira Yasui, Patricia L Kannouche | Human DNA polymerase iota protects ce... | |
| 2008 | Asami Hishiki, Toshiyuki Shimizu, Tomo Hanafusa, Haruo Ohmori, Mamoru Sato, Hiroshi Hashimoto | Initial crystallographic study of hum... | |
| 2007 | Robert W Sobol | DNA polymerase beta null mouse embryo... | |
| 2007 | Wei Wen Yang, Roger Woodgate | What a difference a decade makes: ins... | |
| 2007 | Ekaterina G Frank, Roger Woodgate | Increased catalytic activity and alte... | |
| 2006 | Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich | Biochemical basis of genotoxicity of ... | |
| 2006 | Jeong-Yun Choi, F Peter Guengerich | Kinetic evidence for inefficient and ... | |
| 2006 | Robert E Johnson, Lajos Haracska, Louise Prakash, Satya Prakash | Role of hoogsteen edge hydrogen bondi... | |
| 2006 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Hoogsteen base pair formation promote... | |
| 2006 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Replication past a trans-4-hydroxynon... | |
| 2006 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | An incoming nucleotide imposes an ant... | |
| 2006 | Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich | Translesion synthesis across O6-alkyl... | |
| 2005 | Lajos Haracska, Narottam Acharya, Ildiko Unk, Robert E Johnson, Jerard Hurwitz, Louise Prakash, Satya Prakash | A single domain in human DNA polymera... | |
| 2005 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Human DNA polymerase iota promotes re... | |
| 2005 | Deepak T Nair, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal | Human DNA polymerase iota incorporate... | |
| 2005 | Robert E Johnson, Louise Prakash, Satya Prakash | Biochemical evidence for the requirem... | |
| 2004 | M Todd Washington, Irina G Minko, Robert E Johnson, William T Wolfle, Thomas M Harris, R Stephen Lloyd, Satya Prakash, Louise Prakash | Efficient and error-free replication ... | |
| 2004 | M Todd Washington, Robert E Johnson, Louise Prakash, Satya Prakash | Human DNA polymerase iota utilizes di... | |
| 2004 | Deepak T Nair, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal | Replication by human DNA polymerase-i... | |
| 2004 | Antonio E Vidal, Patricia L Kannouche, Vladimir N Podust, Wei Wen Yang, Alan R Lehmann, Roger Woodgate | Proliferating cell nuclear antigen-de... | |
| 2003 | Thomas A Kunkel, Youri I Pavlov, Katarzyna Bebenek | Functions of human DNA polymerases et... | Full length or truncated,Gap fill,3-5' exo,Overall Error Rate,All properties |
| 2003 | Alexandra Vaisman, Ekaterina G Frank, Shigenori Iwai, Eiji Ohashi, Haruo Ohmori, Fumio Hanaoka, Roger Woodgate | Sequence context-dependent replicatio... | |
| 2003 | Rajendra Prasad, Katarzyna Bebenek, Esther W Hou, David D Shock, William A Beard, Roger Woodgate, Thomas A Kunkel, Samuel H Wilson | Localization of the deoxyribose phosp... | |
| 2002 | Ahmad Faili, Said Aoufouchi, Eric Flatter, Quentin Guéranger, Claude-Agnès Reynaud, Jean-Claude Weill | Induction of somatic hypermutation in... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Ekaterina G Frank, Jane M Sayer, Heiko Kroth, Eiji Ohashi, Haruo Ohmori, Donald M Jerina, Roger Woodgate | Translesion replication of benzo[a]py... | |
| 2001 | M Sander | Human DNA polymerase iota: wrong for ... | |
| 2001 | Katarzyna Bebenek, Agnès Tissier, Ekaterina G Frank, John P McDonald, Rajendra Prasad, Samuel H Wilson, Roger Woodgate, Thomas A Kunkel | 5'-Deoxyribose phosphate lyase activi... | |
| 2001 | Alexandra Vaisman, Agnès Tissier, Ekaterina G Frank, Myron F Goodman, Roger Woodgate | Human DNA polymerase iota promiscuous... | |
| 2001 | Agnès Tissier, Ekaterina G Frank, John P McDonald, Alexandra Vaisman, A R Fernàndez de Henestrosa, François Boudsocq, M P McLenigan, Roger Woodgate | Biochemical characterization of human... | |
| 2001 | Lajos Haracska, Robert E Johnson, Ildiko Unk, Barbara B Phillips, Jerard Hurwitz, Louise Prakash, Satya Prakash | Targeting of human DNA polymerase iot... | |
| 2001 | Patricia J Gearhart, Richard D Wood | Emerging links between hypermutation ... | Associated condition,Overall Error Rate,All properties |
| 2001 | Ekaterina G Frank, Agnès Tissier, John P McDonald, V Rapić-Otrin, Xianmin Zeng, Patricia J Gearhart, Roger Woodgate | Altered nucleotide misinsertion fidel... | |
| 2001 | Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, John-Stephen Taylor, Zhengqiang Wang | Response of human DNA polymerase iota... | |
| 2000 | Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, Zhengqiang Wang | Preferential incorporation of G oppos... | 3-5' exo,All properties |
| 2000 | Agnès Tissier, John P McDonald, Ekaterina G Frank, Roger Woodgate | poliota, a remarkably error-prone hum... | |
| 2000 | Agnès Tissier, Ekaterina G Frank, John P McDonald, Shigenori Iwai, Fumio Hanaoka, Roger Woodgate | Misinsertion and bypass of thymine-th... |
Protein sequence:
Predicted Structure Model
Predicted model
AlphaFold DB
Not experimentally determined
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
Protein information: Uniprot Q9UNA4 search for Human Pol iota at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-Q9UNA4-F1